1. Local advanced rectal cancer perforation in the midst of preoperative chemoradiotherapy: A case report and literature review
- Author
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Yu-ichiro Koma, Ryohei Sasaki, Masashi Yamamoto, Kimihiro Yamashita, Yoshiko Matsuda, Tetsu Nakamura, Nobuhisa Takase, Shingo Kanaji, Hiroshi Hasegawa, Taro Oshikiri, Yasuo Sumi, Masato Komatsu, Satoshi Suzuki, Yoshihiro Kakeji, and Takeru Matsuda
- Subjects
0301 basic medicine ,medicine.medical_specialty ,genetic structures ,Colorectal cancer ,Perforation (oil well) ,Colonoscopy ,Case Report ,Lymph node metastasis ,Preoperative chemoradiotherapy ,03 medical and health sciences ,0302 clinical medicine ,medicine ,5-fluorouracil ,medicine.diagnostic_test ,business.industry ,Tumor necrosis ,General Medicine ,Local advanced rectal cancer ,medicine.disease ,Surgery ,030104 developmental biology ,Rectal Perforation ,030220 oncology & carcinogenesis ,General malaise ,Rectal perforation ,business ,Chemoradiotherapy - Abstract
Standard chemoradiotherapy (CRT) for local advanced rectal cancer (LARC) rarely induce rectal perforation. Here we report a rare case of rectal perforation in a patient with LARC in the midst of preoperative CRT. A 56-year-old male was conveyed to our hospital exhibiting general malaise. Colonoscopy and imaging tests resulted in a clinical diagnosis of LARC with direct invasion to adjacent organs and regional lymphadenopathy. Preoperative 5-fluorouracil-based CRT was started. At 25 d after the start of CRT, the patient developed a typical fever. Computed tomography revealed rectal perforation, and he underwent emergency sigmoid colostomy. At 12 d after the surgery, the remaining CRT was completed according to the original plan. The histopathological findings after radical operation revealed a wide field of tumor necrosis and fibrosis without lymph node metastasis. We share this case as important evidence for the treatment of LARC perforation in the midst of preoperative CRT.
- Published
- 2017