1. Steroid-responsive pancreatitides
- Author
-
Andrea Soriano-Rios, L.F. Uscanga-Domínguez, Mario Pelaez-Luna, and Ana C. Lira-Treviño
- Subjects
Vasculitis ,Connective tissue ,Disease ,Bioinformatics ,03 medical and health sciences ,Immune checkpoint inhibitors ,0302 clinical medicine ,medicine ,Corticosteroids ,Receptor ,Pancreatitides ,Autoimmune pancreatitis ,business.industry ,Minireviews ,General Medicine ,Lymphoplasmacytic sclerosing pancreatitis ,medicine.disease ,Pathophysiology ,medicine.anatomical_structure ,Idiopathic duct centric chronic pancreatitis ,030220 oncology & carcinogenesis ,Acute pancreatitis ,030211 gastroenterology & hepatology ,business - Abstract
Autoimmune pancreatitis has received considerable attention, especially due to the marked effect of corticosteroid therapy on its clinical course. Knowledge, especially regarding type 1 autoimmune pancreatitis, has significantly increased over the last decades, and despite significant differences in pathophysiology and outcomes, both type 1 and 2 autoimmune pancreatitis are still considered different types of the same disease. Some have proposed a different nomenclature reflecting these differences. Although the term steroid-responsive pancreatitides may be interpreted as synonymous to type 1 and 2 autoimmune pancreatitis, these are not the only pancreatic conditions that show a response to steroid therapy. Acute pancreatitis caused by vasculitis and connective tissue diseases and acute pancreatitis secondary to checkpoint inhibitors or programmed cell death receptor antibody-mediated blockage cancer therapy may also benefit from steroid treatment. This review presents current concepts on these disorders, aiming to increase awareness, analyze similarities and differences, and propose a new nomenclature that reflects their specific particularities, clustering them under the term "steroid-responsive pancreatitides".
- Published
- 2020