1. Stem cell differentiation and human liver disease
- Author
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Claire N. Medine, David C. Hay, Wenli Zhou, and Liang Zhu
- Subjects
Cellular differentiation ,Cell ,Review ,Computational biology ,Disease ,Biology ,Regenerative medicine ,Pluripotent stem cells ,Cell Line, Tumor ,EFFICIENT DIFFERENTIATION ,medicine ,Humans ,Polymer chemistry ,Progenitor cell ,Induced pluripotent stem cell ,GENE-EXPRESSION ,FUNCTIONAL HEPATOCYTES ,Transplantation ,Liver development ,HUMAN BLASTOCYSTS ,Bio-artificial liver ,MARROW STROMAL CELLS ,Liver Diseases ,Stem Cells ,Liver Neoplasms ,Gastroenterology ,Cell Differentiation ,IN-VITRO ,General Medicine ,HEPATIC OVAL CELLS ,HEPATOCYTE-LIKE CELLS ,medicine.anatomical_structure ,PROGENITOR CELLS ,Cellular Microenvironment ,Liver ,Differentiation ,Immunology ,Hepatocytes ,DEFINED FACTORS ,Stem cell ,Stem Cell Transplantation - Abstract
Human stem cells are scalable cell populations capable of cellular differentiation. This makes them a very attractive in vitro cellular resource and in theory provides unlimited amounts of primary cells. Such an approach has the potential to improve our understanding of human biology and treating disease. In the future it may be possible to deploy novel stem cell-based approaches to treat human liver diseases. In recent years, efficient hepatic differentiation from human stem cells has been achieved by several research groups including our own. In this review we provide an overview of the field and discuss the future potential and limitations of stem cell technology. (C) 2012 Baishideng. All rights reserved.
- Published
- 2012
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