1. Immunoexpression of cyclooxygenase-2 in primary gastric carcinomas and lymph node metastases
- Author
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Cássio C Santos, Roberto C. P. Lima-Júnior, Raul R R P Feitosa, Belise K Cavada, Francisco Valdeci de Almeida Ferreira, Ronaldo A. Ribeiro, Paulo Roberto Carvalho Almeida, Francisco Dario Rocha-Filho, and Esther A A Falcão
- Subjects
Pathology ,medicine.medical_specialty ,Tissue microarray ,Brief Article ,biology ,business.industry ,medicine.medical_treatment ,Gastroenterology ,General Medicine ,Gastric carcinoma ,medicine.anatomical_structure ,Cyclooxygenase 2 ,Stomach Neoplasms ,Lymphatic Metastasis ,biology.protein ,Humans ,Medicine ,Immunohistochemistry ,Gastrectomy ,Lymph Nodes ,Lymph ,Cyclooxygenase ,business ,Lymph node ,Immunostaining - Abstract
To evaluate immunoexpression of cyclooxygenase-2 (COX-2) in primary gastric carcinomas and respective lymph node metastases.Immunohistochemistry to analyze COX-2 expression was performed on tissue microarray slices obtained from 36 specimens of gastrectomy and satellite lymph nodes from patients with gastric carcinoma.Immunostaining was seen in most cases, and COX-2 expression was higher in lymph node metastases than in corresponding primary gastric tumors of intestinal, diffuse and mixed carcinomas, with a statistically significant difference in the diffuse histotype (P = 0.0108).COX-2 immunoexpression occurs frequently in primary gastric carcinomas, but higher expression of this enzyme is observed in lymph node metastases of the diffuse histotype.
- Published
- 2012