A number of morphophysiological parameters of the candidate crop Lactuca sativa L. for growing in space after influence of the combined action of proton irradiation and clinostating were assessed. It was found that the effect of simulated space conditions reduces the surface area of leaf blades, the mass of roots and shoots of lettuce plants, was not change the number of true leaves. After 20 days of cultivation of L. sativa after irradiation and clinostating, the values of the parameters of the length of shoots, roots, and chlorophyll fluorescence were at the level of control plants. The results obtained contribute to the development of space crop production. Key words: GROWING PLANTS IN SPACE, SALAD CROPS, SOWED LETTUCE, IRRADIATION, PROTONS, STRESS, CLINOSTAT