1. Early Detection of Central Pontine Myelinolysis with MRI: A Case Study
- Author
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Md. Afjalus Siraj, Abdul Ahad Mohammed Ryhan Uddin, Goutam Chowdhury, Rajat Sanker Roy Biswas, Md. Ismail, Mohammed Musfequr Rahman, and Md. Abdur Rouf
- Subjects
Pathology ,medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Magnetic resonance imaging ,Fluid-attenuated inversion recovery ,medicine.disease ,White matter ,Myelin ,medicine.anatomical_structure ,medicine ,Central pontine myelinolysis ,General Materials Science ,Radiology ,Complication ,Hyponatremia ,business ,Tetraplegia - Abstract
Central pontine myelinolysis (CPM) is a complication of treatment of patients with severe hyponatremia. The microscopic appearance of central pontine myelinolysis is loss of myelin with sparing of axons, without evidence of inflammation. The abnormalities associated with central pontine myelinolysis are readily identified on magnetic resonance imaging scans. A patient with central pontine myelinolysis following rapid correction of hyponatremia was studied with magnetic resonance imaging soon after onset of tetraplegia & dysarthria. Affected central pontine white matter showed restricted diffusion on diffusion-weighted images associated with hyper signal on T2-W & FLAIR images. MRI with dedicated sequences is the modality of choice for early detection of osmotic changes in the brain.DOI: http://dx.doi.org/10.3329/cmoshmcj.v13i1.19427
- Published
- 2015
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