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Start Over Author "Itrat Anis" Publisher bangladesh pharmacological society
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1. Molecular docking of viscosine as a new lipoxygenase inhibitor isolated from Dodonaea viscosa

Author

Amir Zada Khan, Akhtar Mohammad, Zafar Iqbal, Itrat Anis, Muhammad Raza Shah, Said Nadeem, Muhammad Rabnawaz, Adnan Shahidullah, Humayun Khan, and Inamullah Khan

Subjects
lcsh:Therapeutics. Pharmacology, Lipoxygenase, Molecular docking, lcsh:RM1-950, Dodonaea viscosa
Abstract

Viscosine was isolated from Dodonaea viscosa, which showed significant lipoxygenase inhibitory activity (IC50: value 39 ± 0.17). Molecular docking simulations were conducted to explore molecular binding mode, and to help elucidate molecular mechanism behind its significant inhibitory activity. Molecular interactions of viscosine with catalytic triad (His523, His518, Ile875) inside active site of lipoxygenase via hydrogen bonding, seems to be the major factor involved in its significant lipoxygenase inhibitory activity.

Published
2012

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