1. Amniotic fluid karyotype analysis and prenatal diagnosis strategy of 3117 pregnant women with amniocentesis indication
- Author
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Yi Liu, Xue-Cheng Sun, Guo-Jian Lv, Ji-Hong Liu, Chen Sun, and Kai Mu
- Subjects
amniocentesis ,chromosome abnormality ,nipt ,non-invasive prenatal dna testing ,prenatal diagnosis ,Public aspects of medicine ,RA1-1270 - Abstract
Aim: To examine prenatal diagnosis strategies through fetal karyotype analysis for 3117 pregnant women with genetic amniocentesis indications. Materials & methods: According to the different indications for amniocentesis, the study was divided into 8 groups. The number of amniocentesis specimens, the number of abnormal karyotypes and the positive rate of each group were analyzed. Results: Compared with prenatal serum screening, noninvasive prenatal DNA testing is more accurate and can effectively improve screening efficiency.Multiple prenatal diagnosis indicators (37.349%) were more likely to be detected than single prenatal diagnosis indicators (11.091%). Conclusion: None of the screeningmethods can completely replace amniocentesis, and for pregnant womenwith genetic indications for amniocentesis, amniocentesis is strongly recommended.
- Published
- 2023
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