1. Regulation of airway innate and adaptive immune responses: the IL-17 paradigm.
- Author
-
Hung LY, Velichko S, Huang F, Thai P, and Wu R
- Subjects
- Animals, Asthma immunology, Bacterial Infections immunology, Humans, Receptors, Interleukin-17 analysis, Receptors, Interleukin-17 physiology, Signal Transduction, Immunity, Innate, Interleukin-17 physiology, Lung immunology
- Abstract
IL-17 is a proinflammatory cytokine produced by immune cells. Its significance in host defense and disease development has been demonstrated in various infection and autoimmune models. Recently, additional studies have shown that IL-17 is also important in modulating airway immune response in several aspects. Along with the well-established Th1/Th2 model, new discoveries regarding the Th17 lineage and IL-17 functions have added an extra twist to the already complicated cytokine network that regulates airway immunity. The IL-17 receptor is expressed on blood cells, as well as on structural cells such as the epithelial cells in the airway. Therefore, the effect of IL-17 on airway immunity is very broad, covering both the innate and the adaptive aspects. In this review, we summarize the findings of recent studies on IL-17 signaling and function in pulmonary immune response, and the implications of IL-17 in disease pathogenesis. more...
- Published
- 2008
- Full Text
- View/download PDF