1. The Use and Development of Retroviral Vectors to Deliver Cytokine Genes for Cancer Therapy
- Author
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Philip Lee Sheridan, Douglas J. Jolly, Timothy Fong, Carlos E. Ibanez, and Sybille L. Sauter
- Subjects
Interleukin 2 ,business.industry ,medicine.medical_treatment ,Genetic enhancement ,Cancer therapy ,General Medicine ,Immunotherapy ,Computational biology ,Virology ,Viral vector ,Titer ,Medicine ,Cytokine genes ,Vector (molecular biology) ,business ,medicine.drug - Abstract
In this review, we describe technical advancements of retroviral vectors to address issues of safety, titer, and clinical scale manufacturing to produce high-quality retroviral vector preparations that have made direct intratumoral administration of cytokine encoding recombinant vectors a feasible cancer therapy in the clinic. We also review possible further advances in retroviral vector design, which may prove important in expanding these clinical applications.
- Published
- 2000
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