1. Malaria: new chemotherapeutic peroxide drugs.
- Author
-
Borstnik K, Paik IH, and Posner GH
- Subjects
- Animals, Antimanic Agents chemistry, Humans, Molecular Structure, Peroxides chemistry, Plasmodium isolation & purification, Structure-Activity Relationship, Antimanic Agents therapeutic use, Malaria drug therapy, Peroxides therapeutic use, Plasmodium drug effects
- Abstract
Chemical insights into artemisinin's biological mechanism of action have allowed rational design of some new trioxane and endoperoxide antimalarial drug candidates that are efficacious and safe. This review summarizes recent achievements in this area of peroxide drug development for malaria chemotherapy.
- Published
- 2002
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