1. The Cell Wall-Associated Proteins in the Dimorphic Pathogenic Species of Paracoccidioides.
- Author
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Puccia R, Vallejo MC, and Longo LVG
- Subjects
- Cell Wall metabolism, Complement System Proteins genetics, Complement System Proteins immunology, Extracellular Vesicles chemistry, Extracellular Vesicles immunology, Fungal Polysaccharides chemistry, Fungal Polysaccharides immunology, Fungal Polysaccharides isolation & purification, Fungal Proteins immunology, Fungal Proteins isolation & purification, Gene Expression, Host-Pathogen Interactions, Humans, Immunity, Innate, Paracoccidioides genetics, Paracoccidioides metabolism, Paracoccidioides pathogenicity, Paracoccidioidomycosis microbiology, Paracoccidioidomycosis pathology, Antibodies, Fungal biosynthesis, Cell Wall chemistry, Fungal Proteins chemistry, Paracoccidioides chemistry, Paracoccidioidomycosis immunology
- Abstract
Paracoccidioides brasiliensis and P. lutzii cause human paracoccidioidomycosis (PCM). They are dimorphic ascomycetes that grow as filaments at mild temperatures up to 28oC and as multibudding pathogenic yeast cells at 37oC. Components of the fungal cell wall have an important role in the interaction with the host because they compose the cell outermost layer. The Paracoccidioides cell wall is composed mainly of polysaccharides, but it also contains proportionally smaller rates of proteins, lipids, and melanin. The polysaccharide cell wall composition and structure of Paracoccidioides yeast cells, filamentous and transition phases were studied in detail in the past. Other cell wall components have been better analyzed in the last decades. The present work gives to the readers a detailed updated view of cell wall-associated proteins. Proteins that have been localized at the cell wall compartment using antibodies are individually addressed. We also make an overview about PCM, the Paracoccidioides cell wall structure, secretion mechanisms, and fungal extracellular vesicles., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.)
- Published
- 2017
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