1. Metformin Ameliorates Neuronal Necroptosis after Intracerebral Hemorrhage by Activating AMPK
- Author
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Guoqiang Zhang, Kaichuang Yang, Jun Yu, and Chenhan Lin
- Subjects
Intracerebral hemorrhage ,Programmed cell death ,business.industry ,Necroptosis ,AMPK ,Type 2 diabetes ,AMP-Activated Protein Kinases ,medicine.disease ,Bioinformatics ,Metformin ,Pathogenesis ,Cellular and Molecular Neuroscience ,Diabetes Mellitus, Type 2 ,Developmental Neuroscience ,Neurology ,medicine ,Humans ,business ,Cerebral Hemorrhage ,Cause of death ,medicine.drug - Abstract
Background: Intracerebral hemorrhage (ICH) is a major cause of death and disability globally. As a type of secondary injury after ICH, treatment for cell death can promote the recovery of neurological function. Methods: Among all the cell death, neuronal necroptosis has recently been demonstrated of significance in the pathogenesis of ICH. However, the administration of drugs against necroptosis has many limitations. Results: In the present study, we found that metformin, a first-line medication for the treatment of type 2 diabetes, can effectively inhibit neuronal necroptosis after ICH by activating the AMPK related pathway, thereby significantly improving neurological function scores and reducing brain edema. Conclusion: These results will provide a new perspective for future research in necroptosis.
- Published
- 2021
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