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4 results on '"Street, Me"'

1. Interactions among pro-inflammatory cytokines, IGF system and thyroid function in pre-pubertal obese subjects.

Author

Street ME, Smerieri A, Montanini L, Predieri B, Iughetti L, Valenzise M, De Luca F, Vigone M, Weber G, Maghnie M, and Bernasconi S

Subjects
Body Mass Index, Body Weight, Child, Female, Humans, Insulin Resistance, Insulin-Like Growth Factor Binding Protein 1 blood, Insulin-Like Growth Factor Binding Protein 2 blood, Insulin-Like Growth Factor Binding Protein 3 blood, Insulin-Like Growth Factor I metabolism, Insulin-Like Growth Factor II metabolism, Interleukin-6 blood, Male, Cytokines blood, Inflammation Mediators blood, Obesity blood, Obesity physiopathology, Puberty blood, Somatomedins metabolism, Thyroid Gland physiopathology
Abstract

Obesity is a state of chronic inflammation. Data on IGF system are often discrepant, and their relationships with mediators of inflammation are unknown. Furthermore, changes in thyroid function have been reported. We aimed at investigating the changes in these systems, and verify any relationships among cytokines, IGF system, thyroid function and insulin-insensitivity. Fifty obese pre-pubertal children, and 55 normal-weight subjects comparable for age and sex were enrolled. Serum IGF-I, IGF-II, IGFBP-1, IGFBP-2, IGFBP-3, IL-6 and TNF-alpha were assayed. In obese children insulin, TSH and FT4 were measured also, and the HOMA-IR index was calculated. Increased IGF-II, IL-6 and TNF-alpha, and decreased IGFBP-1 and IGFBP-2 concentrations were found in obese compared to normal-weight children. The IGF-I/IGFBP-3 molar ratio was also reduced in the obese subjects. In the obese children with high HOMA-IR index, IGFBP-1 and -2 serum concentrations were significantly decreased compared with those with normal insulin sensitivity, and in the obese subjects with increased TSH, IGFBP-2 concentrations were lower, and IGFBP-3 levels were higher compared to their counterparts with normal TSH levels. Among the significant correlations, BMISDS was correlated with IGF-II, and TSH. IGF-II concentrations showed a positive relationship with IL-6. TSH was correlated with IGFBP-2 also. The data showed interactions among IL-6, IGF system, insulin sensitivity, and thyroid function with changes being related to the degree of obesity. Chronic inflammation in obese children was confirmed. Some of the changes in the IGF system could be a consequence of insulin resistance and could account also for later complications in obese subjects.

Published
2013

2. Association of placental insulin, total and activated insulin receptor contents, cortisol and IL-6 concentrations with human birth weight and length: pilot study.

Author

Smerieri A, Petraroli M, Montanini L, Sartori C, Bernasconi S, and Street ME

Subjects
Female, Fetal Growth Retardation metabolism, Humans, Infant, Newborn, Male, Pilot Projects, Pregnancy, Regression Analysis, Birth Weight, Body Height, Hydrocortisone analysis, Insulin analysis, Interleukin-6 analysis, Placenta chemistry, Receptor, Insulin analysis
Abstract

We followed-up, from pregnancy to birth, a group of newborns both IUGR and AGA and we aimed at establishing placental biochemical determinants of birth weight and length. Insulin, total and activated insulin receptor contents (IR), cortisol and IL-6 placental concentrations were assayed in 23 IUGR and 37 AGA subjects at birth, and a multiple regression model was designed and applied to assess the significant biochemical determinants of birth size. IL-6 and activated insulin receptor content were significantly increased in IUGR, whereas insulin, total insulin receptor content, and cortisol placental concentrations were similar in IUGR and AGA. Placental cortisol concentration was found to be significantly and negatively related with both birth length (0.778, P<0.001) and weight (0.508, P<0.008). A negative effect of IL-6 placental concentration was found on birth length (P<0.002). For the first time we provide evidence of a negative association of placental cortisol and IL-6 concentrations on birth size.

Published
2012

3. Placental cortisol and cord serum IGFBP-2 concentrations are important determinants of postnatal weight gain.

Author

Street ME, Smerieri A, Petraroli A, Cesari S, Viani I, Garrubba M, Rossi M, and Bernasconi S

Subjects
Adult, Female, Fetal Growth Retardation metabolism, Humans, Infant, Newborn, Male, Pregnancy, Child Development, Fetal Blood chemistry, Hydrocortisone analysis, Insulin-Like Growth Factor Binding Protein 2 blood, Placenta chemistry, Weight Gain
Abstract

There is a need to identify simple biochemical markers at birth that may predict subjects at risk of growth failure and metabolic complications in later life. Limited research to date has been performed on relationships of specific biochemical determinants at birth with postnatal weight gain and growth. We proposed to establish whether placental cortisol and IL-6 concentrations and cord serum IGF-II and IGFBP-2 concentrations influenced postnatal growth. We followed up from pregnancy 23 IUGR and 37 AGA subjects, and determined placental cortisol and IL-6 concentrations, and cord serum IGF-II, and IGFBP-2 concentrations at birth. We obtained height and weight measurements at 3, 6, 12, 24 months and 5 years of age in 20 IUGR and 15 AGA subjects of comparable gestational age. A multiple linear regression model was designed to establish the effect of the placental and cord serum peptides on postnatal linear growth and weight gain. All IUGR subjects had catch-up growth before 2 years of age. Placental cortisol concentration correlated positively with weight gain during the first 5 years of postnatal growth (P<0.05). Subjects with the highest placental cortisol concentrations were those who showed a greater increase in weight. Cord serum IGFBP-2 concentrations correlated positively with weight gain throughout the 5 year observation period (P:0.003). The subjects with the highest concentrations showed a greater weight gain. Placental cortisol and cord serum IGFBP-2 concentrations were related to postnatal weight gain, suggesting that the fetal environment has long-term effects on growth.

Published
2012

4. A systems biology approach: new insights into fetal growth restriction using Bayesian Networks.

Author

Foltran F, Berchialla P, Bernasconi S, Grossi E, Gregori D, and Street ME

Subjects
Age Factors, Bayes Theorem, Biomarkers analysis, Female, Fetal Growth Retardation genetics, Fetus metabolism, Gene Expression, Gestational Age, Humans, Insulin-Like Growth Factor II genetics, Interleukin-6 genetics, Placenta metabolism, Placentation, Pregnancy, Tumor Necrosis Factor-alpha genetics, Fetal Development physiology, Fetal Growth Retardation metabolism, Fetus abnormalities, Insulin-Like Growth Factor II metabolism, Interleukin-6 metabolism, Systems Biology methods, Tumor Necrosis Factor-alpha metabolism
Abstract

IL-6, IGF-II and IGFBP-2 concentrations in placental lysates were previously shown to be associated with foetal growth. This study aimed to apply a Bayesian Network (BN) model in order to investigate complex dependencies among biochemical and clinical factors and fetal growth outcome. Twenty-one Intra-Uterine Growth Restricted (IUGR) and 25 Appropriate for Gestational Age (AGA) pregnancies were followed throughout pregnancy. Information was collected on maternal and gestational age, neonatal gender, previous gynaecological history. Total protein content, IGF-II, IGFBP-1, IGFBP-2, IL-6, and TNF-alpha concentrations in placental lysates were measured, and IGF-I, IGF-II, IGFBP-1, IGFBP-2 and IL-6 relative gene expression in placenta assessed. A BN and a hybrid forecasting system were implemented: BN revealed a key role of maternal age and TNF-alpha on IUGR and confirmed a close relationship among IGF-II, IL-6 and foetal growth. A relationship between duration of gestation, appropriateness for gestational age, and placental IL-6 concentration was also confirmed. Compared with other techniques, BN showed a better accuracy. Findings confirmed a major role of maternal age in addition to IGF-II, IL-6 and TNF-alpha in IUGR. A direct role of IGFBP-2 was not shown. BN confirmed to be useful in understanding the system's biology and graphically representing variable relationships and hierarchy, particularly where, as in IUGR, many interactions among predictors exist.

Published
2011

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