1. Predictors of mortality and adverse events in patients with infective endocarditis: a retrospective real world study in a surgical centre
- Author
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Niccolò Marchionni, Pierluigi Stefàno, Bruno Alterini, Iacopo Olivotto, Rossella Marcucci, Valentina Scheggi, Valentina Andrei, Irene Merilli, Stefano Del Pace, Nicole Ceschia, and Nicola Zoppetti
- Subjects
Male ,lcsh:Diseases of the circulatory (Cardiovascular) system ,Multivariate analysis ,Time Factors ,030204 cardiovascular system & hematology ,Conservative Treatment ,Valvular dysfunction ,0302 clinical medicine ,Postoperative Complications ,Recurrence ,Risk Factors ,030212 general & internal medicine ,Registries ,Outcome ,Heart Valve Prosthesis Implantation ,Endocarditis ,Age Factors ,Atrial fibrillation ,Middle Aged ,Prognosis ,3. Good health ,Cardiac surgery ,Hospitalization ,Treatment Outcome ,Infective endocarditis ,Female ,Cardiology and Cardiovascular Medicine ,Research Article ,Spondylodiscitis ,medicine.medical_specialty ,Substance-Related Disorders ,Clinical Decision-Making ,Prognostic factors ,Risk Assessment ,Mortality ,03 medical and health sciences ,Predictive Value of Tests ,Internal medicine ,medicine ,Humans ,Adverse effect ,Angiology ,Aged ,Retrospective Studies ,business.industry ,Endocarditis, Bacterial ,medicine.disease ,lcsh:RC666-701 ,business - Abstract
Purpose Mortality in infective endocarditis (IE) is still high, and the long term prognosis remains uncertain. This study aimed to identify predictors of long-term mortality for any cause, adverse event rate, relapse rate, valvular and ventricular dysfunction at follow-up, in a real-world surgical centre. Methods We retrospectively analyzed 363 consecutive episodes of IE (123 women, 34%) admitted to our department with a definite diagnosis of non-device-related IE. Median follow-up duration was 2.9 years. Primary endpoints were predictors of mortality, recurrent endocarditis, and major non-fatal adverse events (hospitalization for any cardiovascular cause, pace-maker implantation, new onset of atrial fibrillation, sternal dehiscence), and ventricular and valvular dysfunction at follow-up. Results Multivariate analysis independent predictors of mortality showed age (HR per unit 1.031, p p p p p p p p p p p p p Conclusions The present study highlights some clinical, readily available factors that can be useful to stratify the prognosis of patients with IE.
- Published
- 2021
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