7 results on '"Peters, Stefan"'
Search Results
2. Concept and study protocol of the process evaluation of a pragmatic randomized controlled trial to promote physical activity in outpatients with heterogeneous mental disorders—the ImPuls study
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Fiedler, David Victor, Rosenstiel, Stephanie, Zeibig, Johanna-Marie, Seiffer, Britta, Welkerling, Jana, Frei, Anna Katharina, Studnitz, Thomas, Baur, Julia, Helmhold, Florian, Ray, Andreas, Herzog, Eva, Takano, Keisuke, Nakagawa, Tristan, Kropp, Saskia, Franke, Sebastian, Peters, Stefan, Flagmeier, Anna Lena, Zwanzleitner, Lena, Sundmacher, Leonie, Ramos-Murguialday, Ander, Hautzinger, Martin, Ehring, Thomas, Sudeck, Gorden, and Wolf, Sebastian
- Published
- 2023
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- View/download PDF
3. Effects of behavioural exercise therapy on the effectiveness of multidisciplinary rehabilitation for chronic non-specific low back pain: a randomised controlled trial
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Semrau, Jana, Hentschke, Christian, Peters, Stefan, and Pfeifer, Klaus
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- 2021
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4. Efficacy and cost-effectiveness of a Transdiagnostic group-based exercise intervention: study protocol for a pragmatic multi-site randomized controlled trial.
- Author
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Wolf, Sebastian, Seiffer, Britta, Zeibig, Johanna-Marie, Welkerling, Jana, Bauer, Leonie Louisa, Frei, Anna Katharina, Studnitz, Thomas, Rosenstiel, Stephanie, Fiedler, David Victor, Helmhold, Florian, Ray, Andreas, Herzog, Eva, Takano, Keisuke, Nakagawa, Tristan, Kropp, Saskia, Franke, Sebastian, Peters, Stefan, El-Kurd, Nadja, Zwanzleitner, Lena, and Sundmacher, Leonie
- Subjects
MENTAL health services ,RESEARCH protocols ,OUTPATIENT medical care ,ARM exercises ,QUALITY-adjusted life years ,PANIC disorders ,BRIEF Symptom Inventory - Abstract
Background: Mental disorders are prevalent and cause considerable burden of disease. Exercise has been shown to be efficacious to treat major depressive disorders, insomnia, panic disorder with and without agoraphobia and post traumatic stress disorder (PTSD). Methods: This pragmatic, two arm, multi-site randomised controlled trial will evaluate the efficacy and cost-effectiveness of the manualized, group-based six-months exercise intervention "ImPuls", among physically inactive patients with major depressive disorders, insomnia, panic disorder, agoraphobia and PTSD within a naturalistic outpatient context in Germany. A minimum of 375 eligible outpatients from 10 different study sites will be block-randomized to either ImPuls in addition to treatment as usual (TAU) or TAU only. ImPuls will be conducted by trained exercise therapists and delivered in groups of six patients. The program will combine (a) moderate to vigorous aerobic exercise carried out two-three times a week for at least 30 min with (b) behavior change techniques for sustained exercise behavior change. All outcomes will be assessed pre-treatment, post-treatment (six months after randomization) and at follow-up (12 months after randomization). Primary outcome will be self-reported global symptom severity assessed with the Brief Symptom Inventory (BSI-18). Secondary outcomes will be accelerometry-based moderate to vigorous physical activity, self-reported exercise, disorder-specific symptoms, quality-adjusted life years (QALY) and healthcare costs. Intention-to-treat analyses will be conducted using mixed models. Cost-effectiveness and cost-utility analysis will be conducted using incremental cost-effectiveness and cost-utility ratios. Discussion: Despite its promising therapeutic effects, exercise programs are currently not provided within the outpatient mental health care system in Germany. This trial will inform service providers and policy makers about the efficacy and cost-effectiveness of the group-based exercise intervention ImPuls within a naturalistic outpatient health care setting. Group-based exercise interventions might provide an option to close the treatment gap within outpatient mental health care settings. Trial registration: The study was registered in the German Clinical Trials Register (ID: DRKS00024152, 05/02/2021). [ABSTRACT FROM AUTHOR]
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- 2021
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- View/download PDF
5. Effects of behavioural exercise therapy on the effectiveness of a multidisciplinary rehabilitation for chronic non-specific low back pain: Study protocol for a randomised controlled trial.
- Author
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Hofmann, Jana, Peters, Stefan, Geidl, Wolfgang, Hentschke, Christian, and Pfeifer, Klaus
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EXERCISE therapy , *LUMBAR pain , *MEDICAL rehabilitation , *PHYSICAL fitness , *BEHAVIOR therapy , *RANDOMIZED controlled trials - Abstract
Background: In Germany, a multidisciplinary rehabilitation named "behavioural medical rehabilitation" (BMR) is available for treatment of chronic low back pain (clbp). A central component of BMR is standard exercise therapy (SET), which is directed mainly to improve physical fitness. There is a need to address psychosocial factors within SET and therefore to improve behavior change with a focus on the development of self-management skills in dealing with clbp. Furthermore, short-term effectiveness of BMR with a SET has been proven, but the impact of a behavioural exercise therapy (BET) for improvement of the long-term effectiveness of BMR is unclear. Methods/design: To compare the effectiveness of two exercise programs with different approaches within BMR on the effects of BMR a prospective randomized controlled trial (RCT) in two rehabilitation centres will be performed. 214 patients aged 18-65 with clbp will be, based on an "urn randomisation"-algorithm, randomly assigned to a BMR with SET (function-oriented, n=107) and BMR with BET (behaviour-oriented, n=107). Both exercise programs have a mean duration of 26 hours in three weeks and are delivered by a limited number of not-blinded study therapists in closed groups with six to twelve patients who will be masked regarding study group. The main differences of BET lie in its detailed manualised program with a theory-based, goal-orientated combination of exercise, education and behavioural elements, active participation of patients and consideration of their individual preferences and previous experiences with exercise. The primary outcome is functional ability assessed with the Hannover Functional Ability Questionnaire directly before and after the rehabilitation program, as well as a six and twelve-month follow-up. Discussion: This RCT is designed to explore the effects of BET on the effectiveness of a BMR compared to a BMR with SET in the management of patients with clbp. Methodological challenges arise from conducting a RCT within routine health care as well as from ensuring high treatment integrity. Findings of this study might contribute to a better understanding of the mechanism of action of BMR and the special effects of BET and may be used to improve the quality of these interventions in routine care, therefore reducing the burden to patients with disabling clbp. [ABSTRACT FROM AUTHOR]
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- 2013
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6. Heterogeneous pattern of differences in respiratory parameters between elderly with either good or poor FEV1.
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Karrasch, Stefan, Behr, Jürgen, Huber, Rudolf M., Nowak, Dennis, Peters, Annette, Peters, Stefan, Holle, Rolf, Jörres, Rudolf A., Schulz, Holger, KORA Study Group, Behr, Jürgen, and Jörres, Rudolf A
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SPIROMETRY ,PULMONARY function tests ,PLETHYSMOGRAPHY ,LEUCOCYTES ,PHYSIOLOGICAL aspects of aging ,AIRWAY resistance (Respiration) ,PULMONARY gas exchange ,TELOMERES - Abstract
Background: The relationship of spirometric values to other respiratory and functional parameters in advanced age is not well studied. We assessed this relationship in elderly subjects with either good or poor spirometric parameters to reveal whether different domains of lung function show comparable differences between the two groups.Methods: Among subjects of the population-based KORA-Age cohort (n = 935, 65-90y; 51% male) two groups were selected from either the lower (LED; n = 51) or the upper (UED; n = 72) end of the FEV1 distribution. All subjects did not have a history of lung disease and were non-smokers at the time of the study. Measurements included spirometry, body plethysmography, diffusing capacity for NO and CO, respiratory pump function and exhaled NO (FeNO). In addition, 6-min walking distance as a functional overall measure, as well as telomere length of blood leukocytes and serum 8-hydroxydeoxyguanosine (8-OHdG) as potential markers of overall biological ageing and stress were determined.Results: In the majority of parameters, LED subjects showed significantly impaired values compared to UED subjects. Differences in spirometric parameters, airway resistance and respiratory pump function ranged between 10% and more than 90% in terms of predicted values. In contrast, volume-related CO and NO diffusing capacity showed differences between groups of lower than 5%, while telomere length, 8-OHdG and FeNO were similar. This was reflected in the differences in "functional age" as derived from prediction equations.Conclusions: In elderly subjects without a history of lung disease differences in spirometric parameters were associated with differences in other lung-mechanical parameters including body plethysmography but not with differences in volume-corrected gas exchange measures. Thus, the concept of a general "lung age" as suggested by the widespread use of this term in connection with spirometry should be considered with caution. [ABSTRACT FROM AUTHOR]- Published
- 2018
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- View/download PDF
7. Heterogeneous pattern of differences in respiratory parameters between elderly with either good or poor FEV 1 .
- Author
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Karrasch S, Behr J, Huber RM, Nowak D, Peters A, Peters S, Holle R, Jörres RA, and Schulz H
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- 8-Hydroxy-2'-Deoxyguanosine, Aged, Aged, 80 and over, Aging genetics, Aging metabolism, Breath Tests, Carbon Monoxide, Deoxyguanosine analogs & derivatives, Deoxyguanosine metabolism, Female, Forced Expiratory Volume, Humans, Leukocytes metabolism, Male, Nitric Oxide, Plethysmography, Whole Body, Pulmonary Diffusing Capacity, Telomere metabolism, Walk Test, Aging physiology, Lung physiopathology
- Abstract
Background: The relationship of spirometric values to other respiratory and functional parameters in advanced age is not well studied. We assessed this relationship in elderly subjects with either good or poor spirometric parameters to reveal whether different domains of lung function show comparable differences between the two groups., Methods: Among subjects of the population-based KORA-Age cohort (n = 935, 65-90y; 51% male) two groups were selected from either the lower (LED; n = 51) or the upper (UED; n = 72) end of the FEV
1 distribution. All subjects did not have a history of lung disease and were non-smokers at the time of the study. Measurements included spirometry, body plethysmography, diffusing capacity for NO and CO, respiratory pump function and exhaled NO (FeNO). In addition, 6-min walking distance as a functional overall measure, as well as telomere length of blood leukocytes and serum 8-hydroxydeoxyguanosine (8-OHdG) as potential markers of overall biological ageing and stress were determined., Results: In the majority of parameters, LED subjects showed significantly impaired values compared to UED subjects. Differences in spirometric parameters, airway resistance and respiratory pump function ranged between 10% and more than 90% in terms of predicted values. In contrast, volume-related CO and NO diffusing capacity showed differences between groups of lower than 5%, while telomere length, 8-OHdG and FeNO were similar. This was reflected in the differences in "functional age" as derived from prediction equations., Conclusions: In elderly subjects without a history of lung disease differences in spirometric parameters were associated with differences in other lung-mechanical parameters including body plethysmography but not with differences in volume-corrected gas exchange measures. Thus, the concept of a general "lung age" as suggested by the widespread use of this term in connection with spirometry should be considered with caution.- Published
- 2018
- Full Text
- View/download PDF
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