1. The expression analysis of <italic>Fra-1</italic> gene and IL-11 protein in Iranian patients with ulcerative colitis.
- Author
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Sabzevary-Ghahfarokhi, Milad, Shohan, Mojtaba, Shirzad, Hedayatollah, Rahimian, Ghorbanali, Bagheri, Nader, Soltani, Amin, Deris, Fatemeh, Ghatreh-Samani, Mahdi, and Razmara, Ehsan
- Subjects
ULCERATIVE colitis ,COLITIS ,GENE expression ,INTERLEUKIN-11 ,TRANSCRIPTION factor AP-1 ,IRANIANS ,GENETICS ,DISEASES ,IMMUNOLOGY - Abstract
Background: Fra-1 (fosl1) belongs to the activator protein1 (AP-1) family inducing
IL-11 expression in oxidative stress condition. IL-11 plays a pivotal role in protecting epithelial barriers integrity. In this study, we investigated theFra-1 gene expression in the inflamed mucosa of patients with ulcerative colitis (UC) as well as its relation to IL-11 expression. Materials and methods: We enrolled 20 patients and 20 healthy controls with definite UC based on the clinical criteria.Fra-1 gene expression in inflamed and non-inflamed colonic biopsies was determined by real-time polymerase chain reaction (RT-PCR). The IL-11 protein concentration was measured by Enzyme-Linked Immunosorbent Assay (ELISA) method. Pearson correlation was applied to calculate the relation between Fra-1 and IL-11. Results: An increased level ofFra-1 gene expression was observed in patients with mild ulcerative colitis. The protein concentration of IL-11 was also increased in mild UC patients. Conversely, a significant decrease of IL-11 protein level was detected in severe UC patients compared to control group. Conclusion: Oxidative stress in inflamed intestinal biopsies can inducefra -1 gene expression. Our findings suggest that Fra-1 transcription factor leads to the production of IL-11 protein in UC patients. [ABSTRACT FROM AUTHOR]- Published
- 2018
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