11 results on '"Hong, Xu"'
Search Results
2. Expert consensus on the prevention, diagnosis and treatment of cold injury in China, 2020.
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Jin, Hong-Xu, Teng, Yue, Dai, Jing, Zhao, Xiao-Dong, Members of the Emergency Medicine Committee of the People's Liberation Army, Cao, Yang, Chen, Cong, Chen, Wei, Fan, Chen-fang, Fei, Jun, Gan, Le-Wen, Guo, Ying-Fei, He, Jian, Huang, Zhi-Gang, Ji, Bin-Long, Li, Nan, Li, Wei-Qin, Liu, Hong-Sheng, Liu, Ming-Hua, and Liu, Shuang-Qing
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EMERGENCY medicine ,PREVENTION of injury ,EPIDEMIOLOGY ,DATA analysis - Abstract
Cold injury refers to local or systemic injury caused by a rapid, massive loss of body heat in a cold environment. The incidence of cold injury is high. However, the current situation regarding the diagnosis and treatment of cold injury in our country is not ideal. To standardize and improve the level of clinical diagnosis and treatment of cold injury in China, it is necessary to make a consensus that is practical and adapted to the conditions in China. We used the latest population-level epidemiological and clinical research data, combined with relevant literature from China and foreign countries. The consensus was developed by a joint committee of multidisciplinary experts. This expert consensus addresses the epidemiology, diagnosis, on-site emergency procedures, in-hospital treatment, and prevention of cold injury. [ABSTRACT FROM AUTHOR]
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- 2021
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3. Multiresistant ST59-SCCmec IV-t437 clone with strong biofilm-forming capacity was identified predominantly in MRSA isolated from Chinese children.
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Xin Yang, Suyun Qian, Kaihu Yao, Lijuan Wang, Yingchao Liu, Fang Dong, Wenqi Song, Jinghui Zhen, Wei Zhou, Hong Xu, Hongyan Zheng, Wenting Li, Yang, Xin, Qian, Suyun, Yao, Kaihu, Wang, Lijuan, Liu, Yingchao, Dong, Fang, Song, Wenqi, and Zhen, Jinghui
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BIOFILMS ,MOLECULAR epidemiology ,MICROBIAL virulence ,MICROBIAL sensitivity tests ,STAPHYLOCOCCUS aureus ,DRUG resistance in microorganisms ,MUPIROCIN ,RESEARCH funding ,STAPHYLOCOCCAL diseases ,METHICILLIN-resistant staphylococcus aureus ,SEQUENCE analysis ,PHARMACODYNAMICS ,PHYSIOLOGY - Abstract
Background: This study aimed to investigate the clinical and molecular epidemiology and biofilm formation of Staphylococcus aureus (SA) isolated from pediatricians in China.Methods: SA strains were isolated from Beijing Children's hospital from February 2016 to January 2017. Isolates were typed by multilocus sequence typing (MLST), spa and SCCmec typing (for Methicillin-resistant SA [MRSA] only). Antimicrobial susceptibility testing was performed by agar dilution method except sulphamethoxazole/trimethoprim (E-test method). Biofilm formation and biofilm associated genes were detected.Results: Totally 104 children (41 females and 63 males; median age, 5.2 months) were enrolled in this study, in which 60 patients suffered from MRSA infection. Among the 104 cases, 54.8% were categorized as community associated SA (CA-SA) infections. The children under 3 years were more likely to occur CA-SA infections compared with older ones (P = 0.0131). ST59-SCCmec IV-t437 (61.7%) was the most prevalent genotype of MRSA, and ST22-t309 (18.2%), ST5-t002 (9.1%), ST6-t701 (9.1%), ST188-t189 (9.1%) were the top four genotypes of methicillin-sensitive SA (MSSA). All the present isolates were susceptible to linezolid, vancomycin, trimethoprim-sulfamethoxazole, mupirocin, tigecyclin, fusidic acid. No erythromycin-susceptible isolate was determined, and only a few isolates (3.8%) were identified as susceptible to penicillin. Multi-drug resistant isolates were reponsible for 83.8% of the ST59-SCCmec IV-t437 isolates. The isolates with strong biofilm formation were found in 85% of MRSA and 53.2% of MSSA, and in 88.7% of ST59-SCCmec IV-t437 isolates. Biofilm formation ability varied not only between MRSA and MSSA (P = 0.0053), but also greatly among different genotypes (P < 0.0001). The prevalence of the biofilm associated genes among ST59-SCCmec IV-t437 clone was: icaA (100.0%), icaD (97.3%), fnbpA (100.0%), fnbpB (0), clfA (100%), clfB (100%), cna (2.7%), bbp (0), ebpS (88.5%), sdrC (78.4%), sdrD (5.4%), and sdrE (94.5%).Conclusions: These results indicated strong homology of the MRSA stains isolated from Chinese children, which was caused by spread of multiresistant ST59-SCCmec IV-t437 clone with strong biofilm formation ability. The MSSA strains, in contrast, were very heterogeneity, half of which could produce biofilm strongly. [ABSTRACT FROM AUTHOR]- Published
- 2017
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4. Cancer incidence in patients with type 2 diabetes mellitus: a population-based cohort study in Shanghai.
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Hui-Lin Xu, Hong Fang, Wang-Hong Xu, Guo-You Qin, Yu-Jie Yan, Bao-Dong Yao, Nai-Qing Zhao, Yi-Nan Liu, Fen Zhang, Wei-Xi Li, Na Wang, Jie Zhou, Jin-Ling Zhang, Li-Yun Zhao, Lun-Qiang Li, Yan-Ping Zhao, Xu, Hui-Lin, Fang, Hong, Xu, Wang-Hong, and Qin, Guo-You
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DISEASE incidence ,CANCER risk factors ,TYPE 2 diabetes ,COHORT analysis ,HEALTH of Chinese people ,ELECTRONIC health records ,POISSON distribution ,TYPE 2 diabetes complications ,LONGITUDINAL method ,PUBLIC health surveillance ,TUMORS ,RELATIVE medical risk - Abstract
Background: Type 2 diabetes mellitus (T2DM) has been suggested to increase the risk of cancers. The aim of this study was to investigate the risk of common cancers in Chinese patients with T2DM.Methods: A population-based retrospective cohort study including 36,379 T2DM patients was conducted in Minhang District of Shanghai, China, during 2004 to 2010. All T2DM patients were enrolled from the standardized management system based on local electronic information system. Newly-diagnosed cancer cases were identified by record-linkage with the Shanghai Cancer Registry. Standardized incidence ratios (SIR) and 95% confidence interval (CI) were used to estimate the risk of cancers among T2DM patients.Results: Overall crude incidence rate (CIR) of cancers was 955.21 per 105 person-years in men and 829.57 per 105 person-years in women. Increased risk of cancer was found in both gender, with an SIR being 1.28 (95% CI = 1.17-1.38) in men and 1.44 (95% CI =1.32-1.55) in women. Increased risk of colon (SIR = 1.97; 95% CI = 1.49 to 2.46), rectum (1.72; 1.23 to 2.21), prostate (2.87; 2.19 to 3.56), and bladder cancers (1.98, 1.28 to 2.68) were observed in men and elevated risk of colon (1.67; 1.25 to 2.08), breast (1.66; 1.38 to 1.95), and corpus uteri cancers (2.87; 2.03 to 3.71) were observed in women.Conclusions: Our results indicate that Chinese patients with T2DM may have an increased risk of some cancers, and the increase may vary by sub-sites of cancers. [ABSTRACT FROM AUTHOR]- Published
- 2015
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5. Mutational analysis of AGXT in two Chinese families with primary hyperoxaluria type 1.
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Guo-min Li, Hong Xu, Qian Shen, Yi-nv Gong, Xiao-yan Fang, Li Sun, Hai-mei Liu, and Yu An
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AUTOSOMAL recessive polycystic kidney ,ALANINE ,AMINOTRANSFERASES ,URINARY calculi ,KIDNEY calcification ,FAMILIES - Abstract
Background Primary hyperoxaluria type 1 is a rare autosomal recessive disease of glyoxylate metabolism caused by a defect in the liver-specific peroxisomal enzyme alanine:glyoxylate aminotransferase (AGT) that leads to hyperoxaluria, recurrent urolithiasis, and nephrocalcinosis. Methods Two unrelated patients with recurrent urolithiasis, along with members of their families, exhibited mutations in the AGXT gene by PCR direct sequencing. Results Two heterozygous mutations that predict truncated proteins, p.S81X and p.S275delinsRAfs, were identified in one patient. The p.S81X mutation is novel. Two heterozygous missense mutations, p.M1T and p.I202N, were detected in another patient but were not identified in her sibling. These four mutations were confirmed to be of paternal and maternal origin. Conclusions These are the first cases of primary hyperoxaluria type 1 to be diagnosed by clinical manifestations and AGXT gene mutations in mainland China. The novel p.S81X and p.I202N mutations detected in our study extend the spectrum of known AGXT gene mutations. [ABSTRACT FROM AUTHOR]
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- 2014
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6. Porcine circovirus type 2 in China: an update on and insights to its prevalence and control.
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Shao-Lun Zhai, Sheng-Nan Chen, Zhi-Hong Xu, Man-Hua Tang, Feng-Guo Wang, Xiao-Jing Li, Bei-Bei Sun, Su-Fang Deng, Jun Hu, Dian-Hong Lv, Xiao-Hui Wen, Jie Yuan, Man-Lin Luo, and Wen-Kang Wei
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CIRCOVIRUS diseases ,GENETIC polymorphisms ,VIRUS diseases ,INFECTIOUS disease transmission ,PUBLIC health - Abstract
Currently, porcine circovirus type 2 (PCV2) is considered the major pathogen of porcine circovirus associated-diseases (PCVAD) that causes large economic losses for the swine industry in the world annually, including China. Since the first report of PCV2 in 1998, it has been drawing tremendous attention for the government, farming enterprises, farmers, and veterinary practitioners. Chinese researchers have conducted a number of molecular epidemiological work on PCV2 by molecular approaches in the past several years, which has resulted in the identification of novel PCV2 genotypes and PCV2-like agents as well as the description of new prevalence patterns. Since late 2009, commercial PCV2 vaccines, including the subunit vaccines and inactivated vaccines, have already been used in Chinese swine farms. The aim of this review is to update the insights into the prevalence and control of PCV2 in China, which would contribute to understanding the epidemiology, control measures and design of novel vaccines for PCV2. [ABSTRACT FROM AUTHOR]
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- 2014
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7. Toxoplasma gondii prevalence in food animals and rodents in different regions of China: isolation, genotyping and mouse pathogenicity.
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Lin Wang, Hua-Wei Cheng, Kai-Quan Huang, Yuan-Hong Xu, Yong-Nian Li, Jian Du, Li Yu, Qing-Li Luo, Wei Wei, Ling Jiang, and Ji-Long Shen
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TOXOPLASMA gondii ,POLYMERASE chain reaction ,LABORATORY mice ,NUCLEOTIDE sequence ,INTRONS - Abstract
Background: Recent studies of Toxoplasma gondii isolates from animals in different regions of China have shown a limited genetic diversity and type China 1 was the dominant genotype of T. gondii prevalent in Chinese animals. However, little has been known concerning the isolation and genotyping of T. gondii circulating in chickens, pigs and rodents in China. The aim of the study was to characterize samples of T. gondii isolates obtained from naturally infected cats, pigs and free-range chickens slaughtered for human consumption in China. Methods: In the present study, brain tissues of 77 animals collected from different areas of China, including 24 free-range chickens (Gallus domesticus) , 13 voles (Rattus flavipectus), 23 pigs and 17 cats, were bioassayed in mice and viable T. gondii were isolated from the brains of eleven. These eleven T. gondii isolates were maintained in Kunming (KM) outbred mice and DNA isolated from tissues of infected mice was characterized using 11 PCR-restriction fragment length polymorphism (PCR-RFLP) markers: SAG1, SAG2, SAG3, BTUB, GRA6, c22-8, c29-2, L358, PK1, Apico, and CS3. Moreover, to determine mouse virulence of China 1 lineage of parasites, a TgCtgy5 genotype isolate was selected randomly and assessed in KM mice with different inoculation doses. Results: Results of genotyping revealed that ten isolates were type China 1 (ToxoDB PCR-RFLP genotype #9), and TgCksz1 was a new genotype that was reported for the first time designated here as ToxoDB PCR-RFLP #225. No clonal types I, II and III lineages were found. DNA sequencing of four introns (EF1, HP2, UPRT1 and UPRT7) and two genes (GRA6 and GRA7) from representative isolates confirmed the results of PCR-RFLP genotyping. The TgCtgy5 isolate was highly virulent in KM mice; all infected mice died of acute toxoplasmosis, irrespective of the inoculation dose. The results indicate that mouse virulent isolates of T. gondii are predominantly circulating in cats in China. Conclusions: T. gondii isolated from chickens, pigs, cats and rodents in different locations in China were genotyped and the results reconfirmed the limited diversity of T. gondii in China and showed that type China 1 lineage was dominant in this country [ABSTRACT FROM AUTHOR]
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- 2013
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8. Combining glycosylated hemoglobin A1c and fasting plasma glucose for diagnosis of type 2 diabetes in Chinese adults.
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Miao Mo, Weijian Zhong, Genming Zhao, Ye Ruan, Hua Zhang, Liang Shi, Dajiang Lu, Qundi Yang, Yanyun Li, Qingwu Jiang, Rui Li, and Wang-Hong Xu
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BLOOD sugar analysis ,TYPE 2 diabetes diagnosis ,MEDICAL screening ,ANALYSIS of variance ,ANTHROPOMETRY ,GLUCOSE tolerance tests ,GLYCOSYLATED hemoglobin ,RESEARCH funding ,STATISTICAL sampling ,STATISTICS ,DATA analysis ,CROSS-sectional method ,DATA analysis software ,DESCRIPTIVE statistics - Abstract
Background: Glycosylated hemoglobin A1c (HbA1c) has been applied to identify type 2 diabetes (T2DM) in the U.S. and European countries. It has not been used in China mainly due to lack of a standardized approach to measure HbA1c, short of knowledge about racial-specific standard and deficiency of an optimal cut-off point. Methods: To evaluate combination of HbA1c and fasting plasma glucose (FPG) in diagnosing T2DM in Chinese adults, a multistage sampling cross-sectional study was conducted in Shanghai, China, in 2009. The FPG measurement, HbA1c assay, and oral glucose tolerance test (OGTT) were performed in 6,661 Chinese adults (3057 men, 3604 women) who had no prior history of diabetes to identify unrecognized T2DM. Results: A total of 454 participants were identified as T2DM based on the 1999 World Health Organization (WHO) diagnostic criteria. Of these patients, 239 were detected using an FPG ≥ 7.0 mmol/l and 141 were further identified using an HbA1c ≥ 43 mmol/mol (6.1%), achieving a sensitivity of 83.7% and a specificity of 89.3% for combining use of FPG and HbA1c. In subjects at high risk of diabetes, the combining use of FPG and HbA1c produced a higher sensitivity and an improved positive predictive value (PPV), and had a satisfactory specificity and negative predictive value (NPV). Conclusions: The combining use of FPG and HbA1c is a potential screening and diagnosis approach for T2DM in Chinese adults, especially among those at high risk of the disease. [ABSTRACT FROM AUTHOR]
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- 2013
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9. Features of complementary and alternative medicine use by patients with coronary artery disease in Beijing: a cross-sectional study.
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Fu-Yong Chu, Xue Yan, Ze Zhang, Xing-Jiang Xiong, Jie Wang, and Hong-Xu Liu
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CORONARY heart disease treatment ,ALTERNATIVE medicine ,CHI-squared test ,CONFIDENCE intervals ,EPIDEMIOLOGY ,QUESTIONNAIRES ,RESEARCH funding ,T-test (Statistics) ,LOGISTIC regression analysis ,DATA analysis ,CROSS-sectional method ,DATA analysis software ,DESCRIPTIVE statistics - Abstract
Background: Complementary and alternative medicine (CAM) is commonly used in China for the management of coronary artery disease (CAD). However, few studies have been conducted to investigate the prevalence, perceived effectiveness, types, and reasons of CAM use in patients diagnosed with CAD. Methods: A cross-sectional study design was adopted. Questionnaires were distributed at the outpatient cardiac clinics of four tertiary-level teaching general hospitals in Beijing. Quantitative data were analyzed using Student's t-test. Categorical data were analyzed using chi-square test. Logistic regression was employed to explore factors associated with the use of CAM as well as CAM use features in Chinese medicine (CM) hospitals when significant differences were found upon comparisons. Results: From May to July, 2009, a total of 600 questionnaires were distributed, and 546 patients with a diagnosis of CAD responded with valid values and were included in the present study. CAM was used by 69.1% of the patients with CAD; the majority (75.9%) of these CAM users believes that CAM is effective. "Few side effects" (49.6%) was the main reason of CAM use; whereas "doubt of effect" (61.5%) was the main reason for non-use. Patent herbal medicine (90.7%) was the most commonly used CAM type. Compared with non-CAM users, CAM users tended to be older (p < 0.01), have a longer disease duration (p = 0.02) and better current health status. In addition, CAM users had significant lower odds for emergency admission and hospitalization within the past one year. Patients with CAD from CM and WM hospitals differ in CAM use frequency, types, perceived effectiveness, as well as reasons for CAM use or non-CAM use. Conclusion: The present study suggested a group of significant factors which could influence the use of CAM in patients with CAD. CAM use patterns differ in patients from CM and WM hospitals. [ABSTRACT FROM AUTHOR]
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- 2013
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10. Validation of the Oxford classification of IgA nephropathy for pediatric patients from China.
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Weibo Le, Cai-Hong Zeng, Zhangsuo Liu, Dong Liu, Qing Yang, Rui-Xia Lin, Zheng-Kun Xia, Zhong-Min Fan, Guanghua Zhu, Ying Wu, Hong Xu, Yihui Zhai, Ying Ding, Xiaoqing Yang, Shaoshan Liang, Hao Chen, Feng Xu, Qian Huang, Hongbing Shen, and Jianming Wang
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IGA glomerulonephritis ,PATIENTS ,PROGNOSIS ,TUBULOINTERSTITIAL nephritis & uveitis syndrome - Abstract
Background: The Oxford classification of IgA nephropathy (IgAN) provides a useful tool for prediction of renal prognosis. However, the application of this classification in children with IgAN needs validation in different patient populations. Methods: A total of 218 children with IgAN from 7 renal centers in China were enrolled. The inclusion criteria was similar to the original Oxford study. Results: There were 98 patients (45%) with mesangial proliferation (M1), 51 patients (23%) with endocapillary proliferation (E1), 136 patients (62%) with segmental sclerosis/adhesion lesion (S1), 13 patients (6%) with moderate tubulointerstitial fibrosis (T1 26-50% of cortex scarred), and only 2 patients (1%) with severe tubulointerstitial fibrosis(T2, >50% of cortex scarred). During a median follow-up duration of 56 months, 24 children (12.4%) developed ESRD or 50% decline in renal function. In univariate COX analysis, we found that tubular atrophy/interstitial fibrosis (HR 4.3, 95%CI 1.8-10.5, P < 0.001) and segmental glomerulosclerosis (HR 9.2 1.2-68.6, P = 0.03) were significant predictors of renal outcome. However, mesangial hypercellularity, endocapillary proliferation, crescents, and necrosis were not associated with renal prognosis. In the multivariate COX regression model, none of these pathologic lesions were shown to be independent risk factors of unfavorable renal outcome except for tubular atrophy/interstitial fibrosis (HR 2.9, 95%CI 1.0-7.9 P = 0.04).Conclusions: We confirmed tubular atrophy/interstitial fibrosis was the only feature independently associated with renal outcomes in Chinese children with IgAN. [ABSTRACT FROM AUTHOR]
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- 2012
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11. Prevalence of the metabolic syndrome in Pudong New Area of Shanghai using three proposed definitions among Chinese adults.
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Wang-hong Xu, Xiao-nan Ruan, Xiao-jin Fu, Qiu-li Zhu, Hong Zhang, Yun Bai, Hong-yan Wu, Yi Zhou, Hua Qiu, Qiao Sun, Qing-wu Jiang, Li-ming Yang, Jian-jun Gu, Gen-ming Zhao, Xu, Wang-hong, Ruan, Xiao-nan, Fu, Xiao-jin, Zhu, Qiu-li, Zhang, Hong, and Bai, Yun
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METABOLIC syndrome , *LIFESTYLES - Abstract
Background: The prevalence of metabolic syndrome (MS) has been increasing in China in recent years. The aim of this study is to estimate and compare the prevalence of MS among Chinese adults in Shanghai, one of the most economic developed areas in China, using definitions proposed by World Health Organization (WHO), National Cholesterol Education Program Adult Treatment Panel (modified ATP III) and International Diabetes Federation (IDF).Methods: This cross-sectional study included 5,584 adults at age 20-79 randomly selected from Pudong New Area of Shanghai, China, through a three-stage sampling. All participants were interviewed in-person between April and July of 2008 to collect information on demographic and lifestyle characteristics. At the interview, anthropometry and blood pressure were measured and bio-specimens were collected.Results: The prevalence estimates for the MS increased with age for each definition in men and women, but the estimates varied greatly between the definitions and by sex. The prevalence of the MS was higher in men (20.2%) than in women (18.7%) using WHO definition but this sex difference was reversed when using the modified ATP III (28.4% for men vs. 35.1% for women) and the IDF (15.9% for men vs. 26.7% for women) criteria. The most common metabolic disorder in this population was dyslipidaemia, regardless of the definition used. Substantial agreement, estimated using the kappa statistic, was found between the modified ATP III and IDF definition, whereas the lowest agreement was observed between the WHO and ATP III criteria.Conclusions: The MS is highly prevalent among Chinese adults in Pudong New Area of Shanghai and the most prevalent component was dyslipidemia. These findings underscore the importance of prevention and control efforts for the MS in this area and the need for a unified predictive definition for the syndrome for use by clinical practitioners and public health agencies. [ABSTRACT FROM AUTHOR]- Published
- 2010
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