12 results on '"Aleixandre‐Benavent, Rafael"'
Search Results
2. Prevalence and comorbidity of autism spectrum disorder in Spain: study protocol for a systematic review and meta-analysis of observational studies
- Author
-
Catalá-López, Ferrán, Ridao, Manuel, Hurtado, Isabel, Núñez-Beltrán, Amparo, Gènova-Maleras, Ricard, Alonso-Arroyo, Adolfo, Tobías, Aurelio, Aleixandre-Benavent, Rafael, Catalá, Miguel A., and Tabarés-Seisdedos, Rafael
- Published
- 2019
- Full Text
- View/download PDF
3. Global mapping of randomised trials related articles published in high-impact-factor medical journals: a cross-sectional analysis
- Author
-
Instituto de Salud Carlos III, Canadian Institutes of Health Research, Ottawa University, Catalá-López, Ferrán, Aleixandre-Benavent, Rafael, Caulley, Lisa, Hutton, Brian, Tabarés-Seisdedos, Rafael, Moher, David, Alonso-Arroyo, Adolfo, Instituto de Salud Carlos III, Canadian Institutes of Health Research, Ottawa University, Catalá-López, Ferrán, Aleixandre-Benavent, Rafael, Caulley, Lisa, Hutton, Brian, Tabarés-Seisdedos, Rafael, Moher, David, and Alonso-Arroyo, Adolfo
- Abstract
[Background]: Randomised controlled trials (RCTs) provide the most reliable information to inform clinical practice and patient care. We aimed to map global clinical research publication activity through RCT-related articles in high-impact-factor medical journals over the past five decades., [Methods]: We conducted a cross-sectional analysis of articles published in the highest ranked medical journals with an impact factor > 10 (according to Journal Citation Reports published in 2017). We searched PubMed/MEDLINE (from inception to December 31, 2017) for all RCT-related articles (e.g. primary RCTs, secondary analyses and methodology papers) published in high-impact-factor medical journals. For each included article, raw metadata were abstracted from the Web of Science. A process of standardization was conducted to unify the different terms and grammatical variants and to remove typographical, transcription and/or indexing errors. Descriptive analyses were conducted (including the number of articles, citations, most prolific authors, countries, journals, funding sources and keywords). Network analyses of collaborations between countries and co-words are presented., [Results]: We included 39,305 articles (for the period 1965–2017) published in forty journals. The Lancet (n = 3593; 9.1%), the Journal of Clinical Oncology (n = 3343; 8.5%) and The New England Journal of Medicine (n = 3275 articles; 8.3%) published the largest number of RCTs. A total of 154 countries were involved in the production of articles. The global productivity ranking was led by the United States (n = 18,393 articles), followed by the United Kingdom (n = 8028 articles), Canada (n = 4548 articles) and Germany (n = 4415 articles). Seventeen authors who had published 100 or more articles were identified; the most prolific authors were affiliated with Duke University (United States), Harvard University (United States) and McMaster University (Canada). The main funding institutions were the National Institutes of Health (United States), Hoffmann-La Roche (Switzerland), Pfizer (United States), Merck Sharp & Dohme (United States) and Novartis (Switzerland). The 100 most cited RCTs were published in nine journals, led by The New England Journal of Medicine (n = 78 articles), The Lancet (n = 9 articles) and JAMA (n = 7 articles). These landmark contributions focused on novel methodological approaches (e.g. the “Bland-Altman method”) and trials on the management of chronic conditions (e.g. diabetes control, hormone replacement therapy in postmenopausal women, multiple therapies for diverse cancers, cardiovascular therapies such as lipid-lowering statins, antihypertensive medications, and antiplatelet and antithrombotic therapy)., [Conclusions]: Our analysis identified authors, countries, funding institutions, landmark contributions and high-impact-factor medical journals publishing RCTs. Over the last 50 years, publication production in leading medical journals has increased, with Western countries leading in research but with low- and middle-income countries showing very limited representation.
- Published
- 2020
4. Prevalence and comorbidity of autism spectrum disorder in Spain: study protocol for a systematic review and meta-analysis of observational studies
- Author
-
Instituto de Salud Carlos III, Catalá-López, Ferrán, Ridao, Manuel, Hurtado, Isabel, Núñez-Beltrán, Amparo, Gènova-Maleras, Ricard, Alonso-Arroyo, Adolfo, Tobías, Aurelio, Aleixandre-Benavent, Rafael, Catalá, Miguel A., Tabarés-Seisdedos, Rafael, Instituto de Salud Carlos III, Catalá-López, Ferrán, Ridao, Manuel, Hurtado, Isabel, Núñez-Beltrán, Amparo, Gènova-Maleras, Ricard, Alonso-Arroyo, Adolfo, Tobías, Aurelio, Aleixandre-Benavent, Rafael, Catalá, Miguel A., and Tabarés-Seisdedos, Rafael
- Abstract
[Background] Autism spectrum disorder (ASD) is a complex developmental disorder characterised by impaired social interaction and communication, and restrictive and repetitive behaviour. Previous systematic reviews have traditionally assessed the prevalence of ASD on global or regional context, with very few meta-analyses at the country level. The objective of this study will be to systematically evaluate published and unpublished observational studies that present prevalence and comorbidity of ASD among children, adolescent and adult population in Spain., [Methods/design] We designed and registered a study protocol for a systematic review and meta-analysis of descriptive epidemiology data. Observational studies (cohort, cross-sectional) reporting the prevalence of ASD and conducted in a wide range of people (e.g. general population, outpatient and/or school settings) will be included. The primary outcome will be the prevalence of ASD. Secondary outcomes will be the prevalence of any physical or mental comorbidity in association with ASD. No limitations will be imposed on publication status, study conduct period, and language of dissemination. Comprehensive literature searches will be conducted in seven electronic databases (from January 1980 onwards), including PubMed/MEDLINE, EMBASE, Scopus, Web of Science, PsycINFO, IME—Spanish Medical Index and IBECS—Spanish Bibliographic Index of Health Sciences. Grey literature will be identified through searching dissertation databases, Google Scholar and conference abstracts. Two team members will independently screen all citations, full-text articles, and abstract data. Potential conflicts will be resolved through discussion. The study methodological quality (or bias) will be appraised using an appropriate tool. If feasible, we will conduct random effects meta-analysis of observational data. Prevalence estimates will be stratified according to gender, age and geographical location. Additional analyses will be conducted to explore the potential sources of heterogeneity (e.g. methodological quality, sample size, diagnostic criteria)., [Discussion] This systematic review and meta-analysis of observational data will identify, evaluate and integrate the epidemiological knowledge underlying the prevalence of ASD in Spain. The results of this study will be of interest to multiple audiences including patients, their families, caregivers, healthcare professional, scientists and policy makers. Results will be published in a peer-reviewed journal. Implications for future epidemiological research will be discussed.
- Published
- 2019
5. The quality of reporting methods and results of cost-effectiveness analyses in Spain: a methodological systematic review
- Author
-
Canadian Institutes of Health Research, Instituto de Salud Carlos III, Generalitat Valenciana, Catalá-López, Ferrán, Alonso-Arroyo, Adolfo, Aleixandre-Benavent, Rafael, Canadian Institutes of Health Research, Instituto de Salud Carlos III, Generalitat Valenciana, Catalá-López, Ferrán, Alonso-Arroyo, Adolfo, and Aleixandre-Benavent, Rafael
- Abstract
[Background]: Cost-effectiveness analysis has been recognized as an important tool to determine the efficiency of healthcare interventions and services. There is a need for evaluating the reporting of methods and results of cost-effectiveness analyses and establishing their validity. We describe and examine reporting characteristics of methods and results of cost-effectiveness analyses conducted in Spain during more than two decades. [Methods]: A methodological systematic review was conducted with the information obtained through an updated literature review in PubMed and complementary databases (e.g. Scopus, ISI Web of Science, National Health Service Economic Evaluation Database (NHS EED) and Health Technology Assessment (HTA) databases from Centre for Reviews and Dissemination (CRD), Índice Médico Español (IME) Índice Bibliográfico Español en Ciencias de la Salud (IBECS)). We identified cost-effectiveness analyses conducted in Spain that used quality-adjusted life years (QALYs) as outcome measures (period 1989-December 2014). Two reviewers independently extracted the data from each paper. The data were analysed descriptively. [Results]: In total, 223 studies were included. Very few studies (10; 4.5 %) reported working from a protocol. Most studies (200; 89.7 %) were simulation models and included a median of 1000 patients. Only 105 (47.1 %) studies presented an adequate description of the characteristics of the target population. Most study interventions were categorized as therapeutic (189; 84.8 %) and nearly half (111; 49.8 %) considered an active alternative as the comparator. Effectiveness of data was derived from a single study in 87 (39.0 %) reports, and only few (40; 17.9 %) used evidence synthesis-based estimates. Few studies (42; 18.8 %) reported a full description of methods for QALY calculation. The majority of the studies (147; 65.9 %) reported that the study intervention produced >more costs and more QALYs> than the comparator. Most studies (200; 89.
- Published
- 2016
6. Global collaborative networks on meta-analyses of randomized trials published in high impact factor medical journals: a social network analysis
- Author
-
Ottawa University, Canadian Institutes of Health Research, Catalá-López, Ferrán, Alonso-Arroyo, Adolfo, Hutton, Brian, Aleixandre-Benavent, Rafael, Moher, David, Ottawa University, Canadian Institutes of Health Research, Catalá-López, Ferrán, Alonso-Arroyo, Adolfo, Hutton, Brian, Aleixandre-Benavent, Rafael, and Moher, David
- Abstract
Background Research collaboration contributes to the advancement of knowledge by exploiting the results of scientific efforts more efficiently, but the global patterns of collaboration on meta-analysis are unknown. The purpose of this research was to describe and characterize the global collaborative patterns in meta-analyses of randomized trials published in high impact factor medical journals over the past three decades. Methods This was a cross-sectional, social network analysis. We searched PubMed for relevant meta-analyses of randomized trials published up to December 2012. We selected meta-analyses (including at least randomized trials as primary evidence source) published in the top seven high impact factor general medical journals (according to Journal Citation Reports 2011): The New England Journal of Medicine, The Lancet, the BMJ, JAMA, Annals of Internal Medicine, Archives of Internal Medicine (now renamed JAMA Internal Medicine), and PLoS Medicine. Opinion articles, conceptual papers, narrative reviews, reviews without meta-analysis, reviews of reviews, and other study designs were excluded. Results Overall, we included 736 meta-analyses, in which 3,178 authors, 891 institutions, and 51 countries participated. The BMJ was the journal that published the greatest number of articles (39%), followed by The Lancet (18%), JAMA (15%) and the Archives of Internal Medicine (15%). The USA, the UK, and Canada headed the absolute global productivity ranking in number of papers. The 64 authors and the 39 institutions with the highest publication rates were identified. We also found 82 clusters of authors (one group with 55 members and one group with 54 members) and 19 clusters of institutions (one major group with 76 members). The most prolific authors were mainly affiliated with the University of Oxford (UK), McMaster University (Canada), and the University of Bern (Switzerland). Conclusions Our analysis identified networks of authors, institutions and coun
- Published
- 2014
7. An analysis of abstracts presented to the College on Problems of Drug Dependence meeting and subsequent publication in peer review journals
- Author
-
Universitat Politècnica de València. Departamento de Comunicación Audiovisual, Documentación e Historia del Arte - Departament de Comunicació Audiovisual, Documentació i Història de l'Art, Valderrama-Zurián, Juan Carlos, Bolaños-Pizarro, Máxima, Bueno-Cañigral, Francisco Jesús, Álvarez, F. Javier, Ontalba Ruipérez, José Antonio, Aleixandre-Benavent, Rafael, Universitat Politècnica de València. Departamento de Comunicación Audiovisual, Documentación e Historia del Arte - Departament de Comunicació Audiovisual, Documentació i Història de l'Art, Valderrama-Zurián, Juan Carlos, Bolaños-Pizarro, Máxima, Bueno-Cañigral, Francisco Jesús, Álvarez, F. Javier, Ontalba Ruipérez, José Antonio, and Aleixandre-Benavent, Rafael
- Abstract
Background: Subsequent publication rate of abstracts presented at meetings is seen as an indicator of the interest and quality of the meeting. We have analyzed characteristics and rate publication in peer-reviewed journals derived from oral communications and posters presented at the 1999 College on Problems of Drug Dependence (CPDD) meeting. Methods: All 689 abstracts presented at the 1999 CPDD meeting were reviewed. In order to find the existence of publications derived from abstracts presented at that meeting, a set of bibliographical searches in the database Medline was developed in July 2006. Information was gathered concerning the abstracts, articles and journals in which they were published. Results: 254 out of 689 abstracts (36.9%) gave rise to at least one publication. The oral communications had a greater likelihood of being published than did the posters (OR = 2.53, 95% CI 1.80-3.55). The average time lapse to publication of an article was 672.97 days. The number of authors per work in the subsequent publications was 4.55. The articles were published in a total of 84 journals, of which eight were indexed with the subject term Substance-Related Disorders. Psychopharmacology (37 articles, 14.5%) was the journal that published the greatest number of articles subsequent to the abstracts presented at the 1999 CPDD meeting. Conclusion: One out of every three abstracts presented to the 1999 CPDD meeting were later published in peer-reviewed journals indexed in Medline. The subsequent publication of the abstracts presented in the CPDD meetings should be actively encouraged, as this maximizes the dissemination of the scientific research and therefore the investment.
- Published
- 2009
8. An analysis of abstracts presented to the College on Problems of Drug Dependence meeting and subsequent publication in peer review journals
- Author
-
Ayuntamiento de Valencia, Universidad de Valencia, Valderrama-Zurián, Juan Carlos, Bolaños-Pizarro, Máxima, Bueno-Cañigral, Francisco Jesús, Álvarez, F. Javier, Ontalba-Ruipérez, José Antonio, Aleixandre-Benavent, Rafael, Ayuntamiento de Valencia, Universidad de Valencia, Valderrama-Zurián, Juan Carlos, Bolaños-Pizarro, Máxima, Bueno-Cañigral, Francisco Jesús, Álvarez, F. Javier, Ontalba-Ruipérez, José Antonio, and Aleixandre-Benavent, Rafael
- Abstract
Background: Subsequent publication rate of abstracts presented at meetings is seen as an indicator of the interest and quality of the meeting. We have analyzed characteristics and rate publication in peer-reviewed journals derived from oral communications and posters presented at the 1999 College on Problems of Drug Dependence (CPDD) meeting., Methods: All 689 abstracts presented at the 1999 CPDD meeting were reviewed. In order to find the existence of publications derived from abstracts presented at that meeting, a set of bibliographical searches in the database Medline was developed in July 2006. Information was gathered concerning the abstracts, articles and journals in which they were published., Results: 254 out of 689 abstracts (36.9%) gave rise to at least one publication. The oral communications had a greater likelihood of being published than did the posters (OR = 2.53, 95% CI 1.80-3.55). The average time lapse to publication of an article was 672.97 days. The number of authors per work in the subsequent publications was 4.55. The articles were published in a total of 84 journals, of which eight were indexed with the subject term Substance-Related Disorders. Psychopharmacology (37 articles, 14.5%) was the journal that published the greatest number of articles subsequent to the abstracts presented at the 1999 CPDD meeting., Conclusion: One out of every three abstracts presented to the 1999 CPDD meeting were later published in peer-reviewed journals indexed in Medline. The subsequent publication of the abstracts presented in the CPDD meetings should be actively encouraged, as this maximizes the dissemination of the scientific research and therefore the investment.
- Published
- 2009
9. Prevalence and comorbidity of attention deficit hyperactivity disorder in Spain: study protocol for extending a systematic review with updated meta-analysis of observational studies.
- Author
-
Catalá-López, Ferrán, Ridao, Manuel, Núñez-Beltrán, Amparo, Gènova-Maleras, Ricard, Alonso-Arroyo, Adolfo, Aleixandre-Benavent, Rafael, Catalá, Miguel A., and Tabarés-Seisdedos, Rafael
- Subjects
ATTENTION-deficit hyperactivity disorder ,ADULTS ,META-analysis ,DISEASES ,SCIENCE - Abstract
Background: Attention deficit hyperactivity disorder (ADHD) is a childhood-onset disorder characterized by a persistent pattern of symptoms of developmentally inappropriate and impaired inattention and/or hyperactivity/impulsivity, with difficulties often continuing into adulthood. ADHD can come with other comorbid conditions. The aim of this study will be to quantify the prevalence and comorbidity of ADHD among children, adolescent, and adult population in Spain. Methods/design: We designed and registered a study protocol for an update and expansion of a systematic review and meta-analysis of pooled prevalence data. We will include cross-sectional observational studies reporting prevalence of ADHD in Spain and conducted in the general population, outpatient, and/or school settings. The primary outcome will be the prevalence of ADHD. Secondary outcomes will be the prevalence of any physical or mental comorbidity in association with ADHD. No limitations will be imposed on publication status, study conduct period, and language of dissemination. Comprehensive literature searches will be conducted in multiple electronic databases, including PubMed/MEDLINE, EMBASE, Scopus, Web of Science, PsycINFO, IME – Spanish Medical Index, and IBECS – Spanish Bibliographic Index of Health Sciences. We will also search Google Scholar, dissertation databases, and conference abstracts. Two team members will independently screen all citations, full-text articles, and abstract data. Potential conflicts will be resolved through discussion. The methodological quality (or risk of bias) of individual studies will be appraised using an appropriate tool. If feasible, we will conduct random effects meta-analysis. Prevalence estimates will be stratified according to gender, age, and geographical location. Additional analyses will be conducted to explore the potential sources of heterogeneity (e.g., methodological quality, sample size, diagnostic criteria). Discussion: This systematic review and meta-analysis of observational data will provide an updated synthesis of the prevalence and comorbidity of ADHD in Spain. This study will also examine factors that may explain potential variations in prevalence data. The findings of this study will be published in a peer-reviewed journal. Systematic review registration: PROSPERO CRD42018106082. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
10. Global collaborative networks on meta-analyses of randomized trials published in high impact factor medical journals: a social network analysis.
- Author
-
Catalá-López, Ferrán, Alonso-Arroyo, Adolfo, Hutton, Brian, Aleixandre-Benavent, Rafael, and Moher, David
- Abstract
Background: Research collaboration contributes to the advancement of knowledge by exploiting the results of scientific efforts more efficiently, but the global patterns of collaboration on meta-analysis are unknown. The purpose of this research was to describe and characterize the global collaborative patterns in meta-analyses of randomized trials published in high impact factor medical journals over the past three decades.Methods: This was a cross-sectional, social network analysis. We searched PubMed for relevant meta-analyses of randomized trials published up to December 2012. We selected meta-analyses (including at least randomized trials as primary evidence source) published in the top seven high impact factor general medical journals (according to Journal Citation Reports 2011): The New England Journal of Medicine, The Lancet, the BMJ, JAMA, Annals of Internal Medicine, Archives of Internal Medicine (now renamed JAMA Internal Medicine), and PLoS Medicine. Opinion articles, conceptual papers, narrative reviews, reviews without meta-analysis, reviews of reviews, and other study designs were excluded.Results: Overall, we included 736 meta-analyses, in which 3,178 authors, 891 institutions, and 51 countries participated. The BMJ was the journal that published the greatest number of articles (39%), followed by The Lancet (18%), JAMA (15%) and the Archives of Internal Medicine (15%). The USA, the UK, and Canada headed the absolute global productivity ranking in number of papers. The 64 authors and the 39 institutions with the highest publication rates were identified. We also found 82 clusters of authors (one group with 55 members and one group with 54 members) and 19 clusters of institutions (one major group with 76 members). The most prolific authors were mainly affiliated with the University of Oxford (UK), McMaster University (Canada), and the University of Bern (Switzerland).Conclusions: Our analysis identified networks of authors, institutions and countries publishing meta-analyses of randomized trials in high impact medical journals. This valuable information may be used to strengthen scientific capacity for collaboration and to help to promote a global agenda for future research of excellence. [ABSTRACT FROM AUTHOR]- Published
- 2014
- Full Text
- View/download PDF
11. The quality of reporting methods and results of cost-effectiveness analyses in Spain: a methodological systematic review.
- Author
-
Catalá-López F, Ridao M, Alonso-Arroyo A, García-Altés A, Cameron C, González-Bermejo D, Aleixandre-Benavent R, Bernal-Delgado E, Peiró S, Tabarés-Seisdedos R, and Hutton B
- Subjects
- Humans, Spain, Cost-Benefit Analysis economics, Delivery of Health Care economics, Research Design
- Abstract
Background: Cost-effectiveness analysis has been recognized as an important tool to determine the efficiency of healthcare interventions and services. There is a need for evaluating the reporting of methods and results of cost-effectiveness analyses and establishing their validity. We describe and examine reporting characteristics of methods and results of cost-effectiveness analyses conducted in Spain during more than two decades., Methods: A methodological systematic review was conducted with the information obtained through an updated literature review in PubMed and complementary databases (e.g. Scopus, ISI Web of Science, National Health Service Economic Evaluation Database (NHS EED) and Health Technology Assessment (HTA) databases from Centre for Reviews and Dissemination (CRD), Índice Médico Español (IME) Índice Bibliográfico Español en Ciencias de la Salud (IBECS)). We identified cost-effectiveness analyses conducted in Spain that used quality-adjusted life years (QALYs) as outcome measures (period 1989-December 2014). Two reviewers independently extracted the data from each paper. The data were analysed descriptively., Results: In total, 223 studies were included. Very few studies (10; 4.5 %) reported working from a protocol. Most studies (200; 89.7 %) were simulation models and included a median of 1000 patients. Only 105 (47.1 %) studies presented an adequate description of the characteristics of the target population. Most study interventions were categorized as therapeutic (189; 84.8 %) and nearly half (111; 49.8 %) considered an active alternative as the comparator. Effectiveness of data was derived from a single study in 87 (39.0 %) reports, and only few (40; 17.9 %) used evidence synthesis-based estimates. Few studies (42; 18.8 %) reported a full description of methods for QALY calculation. The majority of the studies (147; 65.9 %) reported that the study intervention produced "more costs and more QALYs" than the comparator. Most studies (200; 89.7 %) reported favourable conclusions. Main funding source was the private for-profit sector (135; 60.5 %). Conflicts of interest were not disclosed in 88 (39.5 %) studies., Conclusions: This methodological review reflects that reporting of several important aspects of methods and results are frequently missing in published cost-effectiveness analyses. Without full and transparent reporting of how studies were designed and conducted, it is difficult to assess the validity of study findings and conclusions.
- Published
- 2016
- Full Text
- View/download PDF
12. An analysis of abstracts presented to the college on problems of drug dependence meeting and subsequent publication in peer review journals.
- Author
-
Valderrama-Zurián JC, Bolaños-Pizarro M, Bueno-Cañigral FJ, Alvarez FJ, Ontalba-Ruipérez JA, and Aleixandre-Benavent R
- Subjects
- Humans, Congresses as Topic statistics & numerical data, Periodicals as Topic statistics & numerical data, Substance-Related Disorders
- Abstract
Background: Subsequent publication rate of abstracts presented at meetings is seen as an indicator of the interest and quality of the meeting. We have analyzed characteristics and rate publication in peer-reviewed journals derived from oral communications and posters presented at the 1999 College on Problems of Drug Dependence (CPDD) meeting., Methods: All 689 abstracts presented at the 1999 CPDD meeting were reviewed. In order to find the existence of publications derived from abstracts presented at that meeting, a set of bibliographical searches in the database Medline was developed in July 2006. Information was gathered concerning the abstracts, articles and journals in which they were published., Results: 254 out of 689 abstracts (36.9%) gave rise to at least one publication. The oral communications had a greater likelihood of being published than did the posters (OR = 2.53, 95% CI 1.80-3.55). The average time lapse to publication of an article was 672.97 days. The number of authors per work in the subsequent publications was 4.55. The articles were published in a total of 84 journals, of which eight were indexed with the subject term Substance-Related Disorders. Psychopharmacology (37 articles, 14.5%) was the journal that published the greatest number of articles subsequent to the abstracts presented at the 1999 CPDD meeting., Conclusion: One out of every three abstracts presented to the 1999 CPDD meeting were later published in peer-reviewed journals indexed in Medline. The subsequent publication of the abstracts presented in the CPDD meetings should be actively encouraged, as this maximizes the dissemination of the scientific research and therefore the investment.
- Published
- 2009
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.