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Start Over Author "Barez, Pierre-Yves" Publisher biomed central
1 results on '"Barez, Pierre-Yves"'

1. WIP1 deficiency inhibits HTLV-1 Tax oncogenesis: novel therapeutic prospects for treatment of ATL?

Author

Gillet, Nicolas, Carpentier, Alexandre, Barez, Pierre-Yves, and Willems, Luc

Subjects
CARCINOGENESIS, THERAPEUTICS, HIV, GENETIC mutation, PHOSPHATASES
Abstract

Attenuation of p53 activity appears to be a major step in Human T-lymphotropic virus type 1 (HTLV-1) Tax transformation. However, p53 genomic mutations are late and rather infrequent events in HTLV-1 induced Adult T cell leukemia (ATL). The paper by Zane et al. shows that a mediator of p53 activity, Wild-type p53-induced phosphatase 1 (Wip1), contributes to Tax-induced oncogenesis in a mouse model. Wip1 may therefore be a novel target for therapeutic approaches. [ABSTRACT FROM AUTHOR]

Published
2012
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