8 results on '"Beccaria, Kévin"'
Search Results
2. CNS erythroblastic sarcoma: a potential emerging pediatric tumor type characterized by NFIA::RUNX1T1/3 fusions
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Tauziède-Espariat, Arnault, Lew-Derivry, Lucille, Abbou, Samuel, Métais, Alice, Pierron, Gaëlle, Reynaud, Stéphanie, Masliah-Planchon, Julien, Mariet, Cassandra, Hasty, Lauren, Dangouloff-Ros, Volodia, Boddaert, Nathalie, Csanyi, Marie, Aline-Fardin, Aude, Lamaison, Claire, Chrétien, Fabrice, Beccaria, Kévin, Puget, Stéphanie, and Varlet, Pascale
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- 2024
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3. Diagnostic accuracy of a minimal immunohistochemical panel in at/rt molecular subtyping, correlated to dna-methylation profiling
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Tauziède-Espariat, Arnault, Masliah-Planchon, Julien, Andrianteranagna, Mamy, Sievers, Philipp, Sahm, Felix, von Deimling, Andreas, Hasty, Lauren, Delattre, Olivier, Beccaria, Kévin, Métais, Alice, Chrétien, Fabrice, Varlet, Pascale, and Bourdeaut, Franck
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- 2023
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4. Pediatric high-grade glioma MYCN is frequently associated with Li-Fraumeni syndrome
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Guerrini-Rousseau, Léa, Tauziède-Espariat, Arnault, Castel, David, Rouleau, Etienne, Sievers, Philipp, Saffroy, Raphaël, Beccaria, Kévin, Blauwblomme, Thomas, Hasty, Lauren, Bourdeaut, Franck, Grill, Jacques, Varlet, Pascale, and Debily, Marie-Anne
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- 2023
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5. The EP300:BCOR fusion extends the genetic alteration spectrum defining the new tumoral entity of “CNS tumors with BCOR internal tandem duplication”
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Tauziède-Espariat, Arnault, Pierron, Gaëlle, Siegfried, Aurore, Guillemot, Delphine, Uro-Coste, Emmanuelle, Nicaise, Yvan, Castel, David, Catalaa, Isabelle, Larrieu-Ciron, Delphine, Chaynes, Patrick, de Barros, Amaury, Nicolau, Julien, Gareton, Albane, Lechapt, Emmanuèle, Chrétien, Fabrice, Bourdeaut, Franck, Doz, François, Bouchoucha, Yassine, Grill, Jacques, Beccaria, Kévin, Boddaert, Nathalie, Saffroy, Raphaël, Pagès, Mélanie, and Varlet, Pascale
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- 2020
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6. Paediatric Chordomas.
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Beccaria, Kévin, Sainte-Rose, Christian, Zerah, Michel, and Puget, Stéphanie
- Abstract
Paediatric chordomas are rare malignant tumours arising from primitive notochordal remnants with a high rate of recurrence. Only 5 % of them occur in the first two decades such less than 300 paediatric cases have been reported so far in the literature. In children, the average age at diagnosis is 10 years with a male-to-female ratio closed to 1. On the opposite to adults, the majority of paediatric chordomas are intracranial, characteristically centered on the sphenooccipital synchondrosis. Metastatic spread seems to be the prerogative of the under 5-year-old children with more frequent sacro-coccygeal locations and undifferentiated histology. The clinical presentation depends entirely on the tumour location. The most common presenting symptoms are diplopia and signs of raised intracranial pressure. Sacrococcygeal forms may present with an ulcerated subcutaneous mass, radicular pain, bladder and bowel dysfunctions. Diagnosis is suspected on computerised tomography showing the bone destruction and with typically lobulated appearance, hyperintense on T2-weighted magnetic resonance imaging. Today, treatment relies on as complete surgical resection as possible (rarely achieved because of frequent invasiveness of functional structures) followed by adjuvant radiotherapy by proton therapy. The role of chemotherapy has not been proven. Prognosis is better than in adults and depends on the extent of surgical resection, age and histology subgroup. Biological markers are still lacking to improve prognosis by developing targeted therapy. [ABSTRACT FROM AUTHOR]
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- 2015
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7. 5th International Symposium on Focused Ultrasound: North Bethesda, MD, USA. 28 August- 1 September 2016
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Zaaroor, Menashe, Sinai, Alon, Goldsher, Dorit, Eran, Ayelet, Nassar, Maria, Schlesinger, Ilana, Parker, Jonathon, Ravikumar, Vinod, Ghanouni, Pejman, Stein, Sherman, Halpern, Casey, Krishna, Vibhor, Hargrove, Amelia, Agrawal, Punit, Changizi, Barbara, Bourekas, Eric, Knopp, Michael, Rezai, Ali, Mead, Brian, Kim, Namho, Mastorakos, Panagiotis, Suk, Jung Soo, Miller, Wilson, Klibanov, Alexander, Hanes, Justin, Price, Richard, Wang, Shutao, Olumolade, Oluyemi, Kugelman, Tara, Jackson-Lewis, Vernice, Karakatsani, Maria Eleni (Marilena), Han, Yang, Przedborski, Serge, Konofagou, Elisa, Hynynen, Kullervo, Aubert, Isabelle, Leinenga, Gerhard, Nisbet, Rebecca, Hatch, Robert, Van der Jeugd, Anneke, Evans, Harrison, Götz, Jürgen, Van der Jeugd, Ann, Fishman, Paul, Yarowsky, Paul, Frenkel, Victor, Wei-Bin, Shen, Nguyen, Ben, Sanchez, Carlos Sierra, Acosta, Camilo, Chen, Cherry, Wu, Shih-Ying, Aryal, Muna, Papademetriou, Iason T., Zhang, Yong-Zhi, Power, Chanikarn, McDannold, Nathan, Porter, Tyrone, Kovacs, Zsofia, Kim, Saejeong, Jikaria, Neekita, Qureshi, Farhan, Bresler, Michele, Frank, Joseph, Odéen, Henrik, Chiou, George, Snell, John, Todd, Nick, Madore, Bruno, Parker, Dennis, Pauly, Kim Butts, Marx, Mike, Jonathan, Sumeeth, Grissom, William, Arvanitis, Costas, Clement, Gregory, de Bever, Joshua, Payne, Allison, Christensen, Douglas, Maimbourg, Guillaume, Santin, Mathieu David, Houdouin, Alexandre, Lehericy, Stéphane, Tanter, Mickael, Aubry, Jean Francois, Federau, Christian, Werner, Beat, Paeng, Dong-Guk, Xu, Zhiyuan, Quigg, Anders, Eames, Matt, Jin, Changzhu, Everstine, Ashli, Sheehan, Jason, Lopes, M. Beatriz, Kassell, Neal, Drake, James, Price, Karl, Lustgarten, Lior, Sin, Vivian, Mougenot, Charles, Donner, Elizabeth, Tam, Emily, Hodaie, Mojgan, Waspe, Adam, Looi, Thomas, Pichardo, Samuel, Lee, Wonhye, Chung, Yong An, Jung, Yujin, Song, In-Uk, Yoo, Seung-Schik, Kim, Hyun-Chul, Lee, Jong-Hwan, Caskey, Charles, Zinke, Wolf, Cosman, Josh, Shuman, Jillian, Schall, Jeffrey, Aurup, Christian, Chen, Hong, Kamimura, Hermes, Carneiro, Antonio, Sun, Tao, Nazai, Navid, Patz, Sam, Livingstone, Margaret, Mainprize, Todd, Huang, Yuexi, Alkins, Ryan, Chapman, Martin, Perry, James, Lipsman, Nir, Bethune, Allison, Sahgal, Arjun, Trudeau, Maureen, Liu, Hao-Li, Hsu, Po-Hung, Wei, Kuo-Chen, Sutton, Jonathan, Alexander, Phillip, Miller, Eric, Kobus, Thiele, Carpentier, Alexandre, Canney, Michael, Vignot, Alexandre, Beccaria, Kevin, Leclercq, Delphine, Lafon, Cyril, Chapelon, Jean Yves, Hoang-Xuan, Khe, Delattre, Jean-Yves, Idbaih, Ahmed, Moore, David, Xu, Alexis, Schmitt, Paul, Foley, Jessica, Sukovich, Jonathan, Cain, Charles, Pandey, Aditya, Chaudhary, Neeraj, Camelo-Piragua, Sandra, Allen, Steven, Cannata, Jon, Teofilovic, Dejan, Bertolina, Jim, Hall, Timothy, Xu, Zhen, Grondin, Julien, Ferrera, Vincent, ter Haar, Gail, Mouratidis, Petros, Repasky, Elizabeth, Timbie, Kelsie, Badr, Lena, Campbell, Benjamin, McMichael, John, Buckner, Andrew, Prince, Jessica, Stevens, Aaron, Bullock, Timothy, Skalina, Karin, Guha, Chandan, Orsi, Franco, Bonomo, Guido, Vigna, Paolo Della, Mauri, Giovanni, Varano, Gianluca, Schade, George, Wang, Yak-Nam, Pillarisetty, Venu, Hwang, Joo Ha, Khokhlova, Vera, Bailey, Michael, Khokhlova, Tatiana, Sinilshchikov, Ilya, Yuldashev, Petr, Andriyakhina, Yulia, Kreider, Wayne, Maxwell, Adam, Sapozhnikov, Oleg, Partanen, Ari, Lundt, Jonathan, Preusser, Tobias, Haase, Sabrina, Bezzi, Mario, Jenne, Jürgen, Langø, Thomas, Midiri, Massimo, Mueller, Michael, Sat, Giora, Tanner, Christine, Zangos, Stephan, Guenther, Matthias, Melzer, Andreas, Menciassi, Arianna, Tognarelli, Selene, Cafarelli, Andrea, Diodato, Alessandro, Ciuti, Gastone, Rothluebbers, Sven, Schwaab, Julia, Strehlow, Jan, Mihcin, Senay, Tretbar, Steffen, Payen, Thomas, Palermo, Carmine, Sastra, Steve, Olive, Kenneth, Adams, Matthew, Salgaonkar, Vasant, Scott, Serena, Sommer, Graham, Diederich, Chris, Vidal-Jove, Joan, Perich, Eloi, Ruiz, Antonio, Velat, Manuela, Melodelima, David, Dupre, Aurelien, Vincenot, Jeremy, Yao, Chen, Perol, David, Rivoire, Michel, Tucci, Samantha, Mahakian, Lisa, Fite, Brett, Ingham, Elizabeth, Tam, Sarah, Hwang, Chang-il, Tuveson, David, Ferrara, Katherine, Scionti, Stephen, Chen, Lili, Cvetkovic, Dusica, Chen, Xiaoming, Gupta, Roohi, Wang, Bin, Ma, Charlie, Bader, Kenneth, Haworth, Kevin, Holland, Christy, Sanghvi, Narendra, Carlson, Roy, Chen, Wohsing, Chaussy, Christian, Thueroff, Stefan, Cesana, Claudio, Bellorofonte, Carlo, Wang, Qingguo, Wang, Han, Wang, Shengping, Zhang, Junhai, Bazzocchi, Alberto, Napoli, Alessandro, Staruch, Robert, Bing, Chenchen, Shaikh, Sumbul, Nofiele, Joris, Szczepanski, Debra, Staruch, Michelle Wodzak, Williams, Noelle, Laetsch, Theodore, Chopra, Rajiv, Rosenberg, Jarrett, Bitton, Rachelle, LeBlang, Suzanne, Meyer, Joshua, Hurwitz, Mark, Yarmolenko, Pavel, Celik, Haydar, Eranki, Avinash, Beskin, Viktoriya, Santos, Domiciano, Patel, Janish, Oetgen, Matthew, Kim, AeRang, Kim, Peter, Sharma, Karun, Chisholm, Alexander, Aleman, Dionne, Scipione, Roberto, Temple, Michael, Amaral, Joao Guilherme, Endre, Ruby, Lamberti-Pasculli, Maria, de Ruiter, Joost, Campbell, Fiona, Stimec, Jennifer, Gupta, Samit, Singh, Manoj, Hopyan, Sevan, Czarnota, Gregory, Brenin, David, Rochman, Carrie, Kovatcheva, Roussanka, Vlahov, Jordan, Zaletel, Katja, Stoinov, Julian, Bucknor, Matthew, Rieke, Viola, Shim, Jenny, Koral, Korgun, Lang, Brian, Wong, Carlos, Lam, Heather, Shinkov, Alexander, Hu, Jim, Zhang, Xi, Macoskey, Jonathan, Ives, Kimberly, Owens, Gabe, Gurm, Hitinder, Shi, Jiaqi, Pizzuto, Matthew, Dillon, Christopher, Christofferson, Ivy, Hilas, Elaine, Shea, Jill, Greillier, Paul, Ankou, Bénédicte, Bessière, Francis, Zorgani, Ali, Pioche, Mathieu, Kwiecinski, Wojciech, Magat, Julie, Melot-Dusseau, Sandrine, Lacoste, Romain, Quesson, Bruno, Pernot, Mathieu, Catheline, Stefan, Chevalier, Philippe, Marquet, Fabrice, Bour, Pierre, Vaillant, Fanny, Amraoui, Sana, Dubois, Rémi, Ritter, Philippe, Haïssaguerre, Michel, Hocini, Mélèze, Bernus, Olivier, Tebebi, Pamela, Burks, Scott, Milo, Blerta, Gertner, Michael, Zhang, Jimin, Wong, Andrew, Liu, Yu, Kheirolomoom, Azadeh, Seo, Jai, Watson, Katherine, Zhang, Hua, Foiret, Josquin, Borowsky, Alexander, Xu, Doudou, Thanou, Maya, Centelles, Miguell, Wright, Mike, Amrahli, Maral, So, Po-Wah, Gedroyc, Wladyslaw, Kneepkens, Esther, Heijman, Edwin, Keupp, Jochen, Weiss, Steffen, Nicolay, Klaas, Grüll, Holger, Nagle, Matthew, Nikolaeva, Anastasia V., Terzi, Marina E., Tsysar, Sergey A., Cunitz, Bryan, Mourad, Pierre, Downs, Matthew, Yang, Georgiana, Wang, Qi, Chen, Johnny, Farry, Justin, Dixon, Adam, Du, Zhongmin, Dhanaliwala, Ali, Hossack, John, Ranjan, Ashish, Maples, Danny, Wardlow, Rachel, Malayer, Jerry, Ramachandran, Akhilesh, Namba, Hirofumi, Kawasaki, Motohiro, Izumi, Masashi, Kiyasu, Katsuhito, Takemasa, Ryuichi, Ikeuchi, Masahiko, Ushida, Takahiro, Crake, Calum, Kothapalli, Satya V. V. N., Leighton, Wan, Wang, Zhaorui, Gach, H. Michael, Straube, William, Altman, Michael, Kim, Young-sun, Lim, Hyo Keun, Rhim, Hyunchul, van Breugel, Johanna, Braat, Manon, Moonen, Chrit, van den Bosch, Maurice, Ries, Mario, Marrocchio, Cristina, Dababou, Susan, Lee, Jae Young, Chung, Hyun Hoon, Kang, Soo Yeon, Kang, Kook Jin, Son, Keon Ho, Zhang, Dandan, Plata, Juan, Jones, Peter, Pascal-Tenorio, Aurea, Bouley, Donna, Bond, Aaron, Dallapiazza, Robert, Huss, Diane, Warren, Amy, Sperling, Scott, Gwinn, Ryder, Shah, Binit, Elias, W. Jeff, Curley, Colleen, Zhang, Ying, Negron, Karina, Abounader, Roger, Samiotaki, Gesthimani, Tu, Tsang-Wei, Papadakis, Georgios, Hammoud, Dima, Silvestrini, Matthew, Wolfram, Frank, Güllmar, Daniel, Reichenbach, Juergen, Hofmann, Denis, Böttcher, Joachim, Schubert, Harald, Lesser, Thomas G., Almquist, Scott, Camarena, Francisco, Jiménez-Gambín, Sergio, Jiménez, Noé, Chang, Jin Woo, Chaplin, Vandiver, Griesenauer, Rebekah, Miga, Michael, Ellens, Nicholas, Airan, Raag, Quinones-Hinojosa, Alfredo, Farahani, Keyvan, Feng, Xue, Fielden, Samuel, Zhao, Li, Wintermark, Max, Meyer, Craig, Guo, Sijia, Lu, Xin, Zhuo, Jiachen, Xu, Su, Gullapalli, Rao, Gandhi, Dheeraj, Brokman, Omer, Baek, Hongchae, Kim, Hyungmin, Leung, Steven, Webb, Taylor, Vykhodtseva, Natalia, Nguyen, Thai-Son, Park, Chang Kyu, Park, Sang Man, Jung, Na Young, Kim, Min Soo, Chang, Won Seok, Jung, Hyun Ho, Plaksin, Michael, Weissler, Yoni, Shoham, Shy, Kimmel, Eitan, Rosnitskiy, Pavel B., Krupa, Steve, Hazan, Eilon, Naor, Omer, Levy, Yoav, Maimon, Noam, Brosh, Inbar, Kahn, Itamar, Cahill, Jessica, Colas, Elodie Constanciel, Wydra, Adrian, Maev, Roman, Aly, Amirah, Sesenoglu-Laird, Ozge, Padegimas, Linas, Cooper, Mark, Waszczak, Barbara, Tehrani, Seruz, Slingluff, Craig, Larner, James, Andarawewa, Kumari, Ozhinsky, Eugene, Shah, Rutwik, Krug, Roland, Deckers, Roel, Linn, Sabine, Suelmann, Britt, Witkamp, Arjen, Vaessen, Paul, van Diest, Paul, Bartels, Lambertus W., Bos, Clemens, Borys, Nicolas, Storm, Gert, Van der Wall, Elsken, Farr, Navid, Alnazeer, Moez, Katti, Prateek, Wood, Bradford, Farrer, Alexis, Ferrer, Cyril, de Senneville, Baudouin Denis, van Stralen, Marijn, Liu, Jingfei, Leach, J. Kent, Zidowitz, Stephan, Lee, Hsin-Lun, Hsu, Fang-Chi, Kuo, Chia-Chun, Jeng, Shiu-Chen, Chen, Tung-Ho, Yang, Nai-Yi, Chiou, Jeng-Fong, Kao, Yi-tzu, Pan, Chia-Hsin, Wu, Jing-Fu, Tsai, Yi-Chieh, Johnson, Sara, Li, Dawei, He, Ye, Karakitsios, Ioannis, Schwenke, Michael, Demedts, Daniel, Xiao, Xu, Cavin, Ian, Minalga, Emilee, Merrill, Robb, Hadley, Rock, Ramaekers, Pascal, de Greef, Martijn, Shahriari, Kian, Parvizi, Mohammad Hossein, Asadnia, Kiana, Chamanara, Marzieh, Kamrava, Seyed Kamran, Chabok, Hamid Reza, Stein, Ruben, Muller, Sébastien, Tan, Jeremy, Zachiu, Cornel, Erasmus, Hans-Peter, Van Arsdell, Glen, Benson, Lee, Jang, Kee W., Angstadt, Mary, Lewis, Bobbi, McLean, Hailey, Hoogenboom, Martijn, Eikelenboom, Dylan, den Brok, Martijn, Wesseling, Pieter, Heerschap, Arend, Fütterer, Jurgen, Adema, Gosse, Wang, Kevin, Zhong, Pei, Joy, Joyce, McLeod, Helen, Kim, Harry, Lewis, Matthew, Ozilgen, Arda, Zahos, Peter, Coughlin, Dezba, Tang, Xinyan, Lotz, Jeff, Jedruszczuk, Kathleen, Gulati, Amitabh, Solomon, Stephen, Kaye, Elena, Mugler, John, Barbato, Gaetano, Scoarughi, Gian Luca, Corso, Cristiano, Gorgone, Alessandro, Migliore, Ilaria Giuseppina, Larrabee, Zachary, Hananel, Arik, Aubry, Jean-Francois, Negussie, Ayele, Wilson, Emmanuel, Seifabadi, Reza, Moon, Hyungwon, Kang, Jeeun, Sim, Changbeom, Chang, Jin Ho, Kim, Hyuncheol, Lee, Hak Jong, Sasaki, Noboru, Takiguchi, Mitsuyoshi, Sebeke, Lukas, Luo, Xi, de Jager, Bram, Heemels, Maurice, Abraham, Christopher, Curiel, Laura, Berriet, Rémi, Janát-Amsbury, Margit, Corea, Joseph, Ye, Patrick Peiyong, Arias, Ana Clauda, Lustig, Micheal, and Svedin, Bryant
- Published
- 2016
- Full Text
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8. Supratentorial non-RELA, ZFTA-fused ependymomas: a comprehensive phenotype genotype correlation highlighting the number of zinc fingers in ZFTA-NCOA1/2 fusions.
- Author
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Tauziède-Espariat A, Siegfried A, Nicaise Y, Kergrohen T, Sievers P, Vasiljevic A, Roux A, Dezamis E, Benevello C, Machet MC, Michalak S, Puiseux C, Llamas-Gutierrez F, Leblond P, Bourdeaut F, Grill J, Dufour C, Guerrini-Rousseau L, Abbou S, Dangouloff-Ros V, Boddaert N, Saffroy R, Hasty L, Wahler E, Pagès M, Andreiuolo F, Lechapt E, Chrétien F, Blauwblomme T, Beccaria K, Pallud J, Puget S, Uro-Coste E, and Varlet P
- Subjects
- Adolescent, Adult, Child, Child, Preschool, DNA Methylation genetics, Ependymoma classification, Ependymoma metabolism, Ependymoma pathology, Female, Gene Fusion genetics, Genotype, Glial Fibrillary Acidic Protein metabolism, Humans, Infant, Male, NF-kappa B metabolism, Neural Cell Adhesion Molecule L1 metabolism, Nuclear Receptor Coactivator 1 genetics, Nuclear Receptor Coactivator 2 genetics, Phenotype, Supratentorial Neoplasms classification, Supratentorial Neoplasms metabolism, Supratentorial Neoplasms pathology, Trans-Activators genetics, Transcription Factor RelA genetics, Tumor Suppressor Proteins genetics, Young Adult, Ependymoma genetics, Proteins genetics, Supratentorial Neoplasms genetics
- Abstract
The cIMPACT-NOW Update 7 has replaced the WHO nosology of "ependymoma, RELA fusion positive" by "Supratentorial-ependymoma, C11orf95-fusion positive". This modification reinforces the idea that supratentorial-ependymomas exhibiting fusion that implicates the C11orf95 (now called ZFTA) gene with or without the RELA gene, represent the same histomolecular entity. A hot off the press molecular study has identified distinct clusters of the DNA methylation class of ZFTA fusion-positive tumors. Interestingly, clusters 2 and 4 comprised tumors of different morphologies, with various ZFTA fusions without involvement of RELA. In this paper, we present a detailed series of thirteen cases of non-RELA ZFTA-fused supratentorial tumors with extensive clinical, radiological, histopathological, immunohistochemical, genetic and epigenetic (DNA methylation profiling) characterization. Contrary to the age of onset and MRI aspects similar to RELA fusion-positive EPN, we noted significant histopathological heterogeneity (pleomorphic xanthoastrocytoma-like, astroblastoma-like, ependymoma-like, and even sarcoma-like patterns) in this cohort. Immunophenotypically, these NFκB immunonegative tumors expressed GFAP variably, but EMA constantly and L1CAM frequently. Different gene partners were fused with ZFTA: NCOA1/2, MAML2 and for the first time MN1. These tumors had epigenetic homologies within the DNA methylation class of ependymomas-RELA and were classified as satellite clusters 2 and 4. Cluster 2 (n = 9) corresponded to tumors with classic ependymal histological features (n = 4) but also had astroblastic features (n = 5). Various types of ZFTA fusions were associated with cluster 2, but as in the original report, ZFTA:MAML2 fusion was frequent. Cluster 4 was enriched with sarcoma-like tumors. Moreover, we reported a novel anatomy of three ZFTA:NCOA1/2 fusions with only 1 ZFTA zinc finger domain in the putative fusion protein, whereas all previously reported non-RELA ZFTA fusions have 4 ZFTA zinc fingers. All three cases presented a sarcoma-like morphology. This genotype/phenotype association requires further studies for confirmation. Our series is the first to extensively characterize this new subset of supratentorial ZFTA-fused ependymomas and highlights the usefulness of ZFTA FISH analysis to confirm the existence of a rearrangement without RELA abnormality., (© 2021. The Author(s).)
- Published
- 2021
- Full Text
- View/download PDF
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