1. Genome characterization of bile-isolated Shewanella algae ACCC.
- Author
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Tseng, Shu-Ying, Tung, Kwong-Chung, Cheng, Jan-Fang, Lee, Yi-Hsuan, Wu, Zong-Yen, Hong, Yu-Kai, Chen, Shi-Yu, Huang, Yao-Ting, and Liu, Po-Yu
- Subjects
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SHEWANELLA alga , *SHEWANELLA , *CHOLECYSTITIS , *NUCLEOTIDE sequencing , *COLISTIN , *CARBAPENEMS - Abstract
Background: Shewanella algae has been recognized as an emerging human pathogen. However, not much is known about the mechanism of its pathogenesis and its adaptation to a special niche such as the hepatobiliary tract. Results: In this study, we isolated the S. algae ACCC strain from human bile and performed whole genome sequencing. S. algae ACCC consists of a circular 4,743,354-bp chromosome with a GC content of 53.08%, within 4080 protein coding sequences. The genome of strain ACCC contains a number of candidate genes which have been reported to be associated with bile adaption, including htpB, exbBD, wecA, galU, adeFGH and phoPQ regulon. Conclusions: Our results highlight the association of S. algae with a rare disease profile. Further studies are needed to shed light on the evolution of pathogenesis and the niche adaptation of S. algae. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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