1. Metabolism of plasma cholesterol and lipoprotein parameters are related to a higher degree of insulin sensitivity in high HDL-C healthy normal weight subjects
- Author
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Natalia B. Panzoldo, E.S. Parra, Edna Regina Nakandakare, Patrícia M. Cazita, Marisa Passarelli, Vanessa Helena de Souza Zago, Matti Jauhiainen, Eliana Cotta de Faria, Camila C. Leança, Eder Carlos da Rocha Quintão, and Valéria S. Nunes
- Subjects
Male ,medicine.medical_treatment ,Endocrinology, Diabetes and Metabolism ,Cholesterol, VLDL ,Ideal Body Weight ,Intestinal absorption ,Phosphatidylcholine-Sterol O-Acyltransferase ,chemistry.chemical_compound ,Medicine ,Insulin ,Phospholipid Transfer Proteins ,Original Investigation ,HDL-C concentration ,biology ,Middle Aged ,Cholesteryl ester transfer protein ,Healthy Volunteers ,lipids (amino acids, peptides, and proteins) ,Female ,Plasma cholesterol metabolism markers ,Cardiology and Cardiovascular Medicine ,Brazil ,Adult ,medicine.medical_specialty ,Phospholipid transfer protein ,Lipid Metabolism, Inborn Errors ,Young Adult ,Insulin resistance ,Lecithin cholesterol acyl transferase ,Internal medicine ,Diabetes mellitus ,Cholesterylester transfer protein ,Humans ,Aged ,business.industry ,Cholesterol ,Cholesterol, HDL ,Lipoprotein lipases ,Lipid metabolism ,Lipase ,medicine.disease ,Lipid Metabolism ,Pre-beta1 HDL ,Cholesterol Ester Transfer Proteins ,Lipoprotein Lipase ,Endocrinology ,chemistry ,Intestinal Absorption ,biology.protein ,business ,Biomarkers ,Lipoprotein - Abstract
Background We have searched if plasma high density lipoprotein-cholesterol (HDL-C) concentration interferes simultaneously with whole-body cholesterol metabolism and insulin sensitivity in normal weight healthy adult subjects. Methods We have measured the activities of several plasma components that are critically influenced by insulin and that control lipoprotein metabolism in subjects with low and high HDL-C concentrations. These parameters included cholesteryl ester transfer protein (CETP), phospholipid transfer protein (PLTP), lecithin cholesterol acyl transferase (LCAT), post-heparin lipoprotein lipase (LPL), hepatic lipase (HL), pre-beta-1HDL, and plasma sterol markers of cholesterol synthesis and intestinal absorption. Results In the high-HDL-C group, we found lower plasma concentrations of triglycerides, alanine aminotransferase, insulin, HOMA-IR index, activities of LCAT and HL compared with the low HDL-C group; additionally, we found higher activity of LPL and pre-beta-1HDL concentration in the high-HDL-C group. There were no differences in the plasma CETP and PLTP activities. Conclusions These findings indicate that in healthy hyperalphalipoproteinemia subjects, several parameters that control the metabolism of plasma cholesterol and lipoproteins are related to a higher degree of insulin sensitivity.
- Published
- 2013