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Background: Evidence shows that mindfulness-based programs reduce levels of stress, anxiety, and depression. Yet, web-based mindfulness has been less studied, especially among university students. We developed a student-centered web-based mindfulness virtual community (MVC) intervention informed by cognitive-behavioral-therapy constructs. MVC comprised of (1) 12 online video-based modules (psychoeducation and practice), (2) anonymous peer-to-peer discussion forums, and (3) anonymous, group-based, 20-min live video conferences by a trained moderator. While the intervention was found effective in reducing anxiety and depression in a randomized controlled trial (RCT), the impact on students' quality of life remained to be examined. The reported study examined the impact of 8-week long web-based MVC intervention on the quality of life of undergraduate students compared to those in the control group. Participants were recruited from a large Canadian university into a two-arm RCT (N = 160) and randomly allocated to the web-based MVC intervention (n = 80) or to the control (n = 80) group. Participants completed online survey at baseline (T1) and at 8-week (T2). The outcome of quality of life was measured by 16-item Quality of Life Scale (QOLS). The generalized estimation equation (GEE) method with AR(1) covariance structures was used, adjusting for potential covariates. Results: At the baseline 159 students completed the survey. Participants (32 males, 125 females, 2 other gender) had a mean age of 22.6 years, 57.2% were born in Canada. Participants in MVC (n = 79) and control (n = 80) groups were similar in sociodemographic characteristics except hours of volunteer work. At T2 that coincided with students' exam period, QOLS score for the control group declined while MVC group had a slight increase. Between-group analysis for QOLS score-change showed a significantly higher score at T2 for MVC group compared to the control (81.64, SD = 14.63 vs. 72.9, SD = 17.26, P < 0.001). Per adjusted GEE analysis, the higher QOLS score in MVC compared to the control group was statistically significant (β = -2.24, P =.03). Conclusions: Web-based MVC intervention helped the students to have better quality of life, compared to the control group, at 8-week follow-up despite exam stress. Future research with a longer follow-up would advance understanding. Trial registration: https://doi.org/10.1186/ISRCTN12249616 Registration Date: 21/06/2017. [ABSTRACT FROM AUTHOR]

Background: The worldwide rise in common mental disorders (CMDs) is posing challenges in the provision of and access to care, particularly for immigrant, refugee and racialized groups from low-income backgrounds. eHealth tools, such as the Interactive Computer-Assisted Client Assessment Survey (iCCAS) may reduce some barriers to access. iCCAS is a tablet-based, touch-screen self-assessment completed by clients while waiting to see their family physician (FP) or nurse practitioner (NP). In an academic-community initiative, iCCAS was made available in English and Spanish at a Community Health Centre in Toronto through a mixed-method trial. Methods: This paper reports the perspectives of clients in the iCCAS group (n = 74) collected through an exit survey, and the perspectives of 9 providers (four FP and five NP) gathered through qualitative interviews. Client acceptance of the tool was assessed for cognitive and technical dimensions of their experience. They rated twelve items for perceived Benefits and Barriers and four questions for the technical quality. Results: Most clients reported that the iCCAS completion time was acceptable (94.5 %), the touch-screen was easy to use (97.3 %), and the instructions (93.2 %) and questions (94.6 %) were clear. Clients endorsed the tool's Benefits, but were unsure about Barriers to information privacy and provider interaction (mean 4.1, 2.6 and 2.8, respectively on a five-point scale). Qualitative analysis of the provider interviews identified five themes: challenges in Assessing Mental Health Services, such as case complexity, time, language and stigma; the Tool's Benefits, including non-intrusive prompting of clients to discuss mental health, and facilitation of providers' assessment and care plans; the Tool's Integration into everyday practice; Challenges for Use (e.g. time); and Promoting Integration Effectively, centered on the timing of screening, setting readiness, language diversity, and technological advances. Conclusions: Participant clients and providers perceived iCCAS as an easy and useful tool for mental health assessments at the Community Health Centre and similar settings. The findings are anticipated to inform further work in this area. [ABSTRACT FROM AUTHOR]

Introduction Experimental litter size manipulations are often not problem free. Typically conducted shortly after birth or oviposition, they do not account for the energy already invested into the production of the offspring. Such effects make it difficult to interpret the results from experimental litter size manipulations and therefore to study optimality of litter or clutch size, a long debated topic in evolutionary biology. Results We propose the use of a mating design based on a selfish genetic element, the t haplotype, to reduce litter size in an eutherian mammal, the house mouse. Most t haplotypes are recessive lethal and therefore lead to the death of all homozygous embryos. Litter sizes can be reduced by up to 50% by pairing a +/t female with a +/t male instead of a +/+ male. Conclusions This method allows litter size manipulation before birth without the use of invasive techniques, therefore providing an excellent tool for studying optimal litter size and ultimately helping to understand life history strategies. [ABSTRACT FROM AUTHOR]