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2 results on '"Guoming Hu"'

1. Tumor-associated tissue eosinophilia predicts favorable clinical outcome in solid tumors: a meta-analysis

Author

Wei Chen, Pu Cheng, Feng Xu, Shimin Wang, Guoming Hu, Liming Huang, and Kefang Zhong

Subjects
0301 basic medicine, Oncology, Cancer Research, medicine.medical_specialty, Lymphovascular invasion, Colorectal cancer, lcsh:RC254-282, 03 medical and health sciences, 0302 clinical medicine, Surgical oncology, Internal medicine, Neoplasms, Eosinophilia, Genetics, medicine, Carcinoma, Favorable outcome, Tumor Microenvironment, Humans, business.industry, Hazard ratio, Odds ratio, medicine.disease, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Prognosis, Tumor-associated tissue eosinophilia, Meta-analysis, 030104 developmental biology, Tumor progression, 030220 oncology & carcinogenesis, Human solid tumor, medicine.symptom, business, Research Article
Abstract

Background Activated eosinophils have been deemed to affect carcinogenesis and tumor progression via various mechanisms in tumor microenvironment. However, the prognostic role of tumor-associated tissue eosinophilia (TATE) in human cancers remains controversial. Therefore, we conducted this meta-analysis to better comprehend the association between TATE and clinical outcomes of patients. Methods We searched PubMed, Embase and EBSCO to determine the researches assessing the association between TATE and overall survival (OS) and/or disease-free survival (DFS) in patients with cancer, then combined relevant data into hazard ratios (HRs) or odds ratio (OR) for OS, DFS and clinicopathological features including lymph node metastasis etc. with STATA 12.0. Results Twenty six researches with 6384 patients were included in this meta-analysis. We found that the presence of TATE was significantly associated with improved OS, but not with DFS in all types of cancers. In stratified analyses based on cancer types, pooled results manifested that the infiltration of eosinophils was remarkably associated with better OS in esophageal carcinoma and colorectal cancer. In addition, TATE significantly inversely correlated with lymph node metastasis, tumor stage and lymphatic invasion of cancer. Conclusion TATE promotes survival in cancer patients, suggesting that it is a valuable prognostic biomarker and clinical application of biological response modifiers or agonists promoting TATE may be the novel therapeutic strategy for patients.

Published
2020

2. Retrospective and comparative analysis of (99m)Tc-Sestamibi breast specific gamma imaging versus mammography, ultrasound, and magnetic resonance imaging for the detection of breast cancer in Chinese women.

Author

Xiuyan Yu, Guoming Hu, Zhigang Zhang, Fuming Qiu, Xuan Shao, Xiaochen Wang, Hongwei Zhan, Yiding Chen, Yongchuan Deng, Jian Huang, Yu, Xiuyan, Hu, Guoming, Zhang, Zhigang, Qiu, Fuming, Shao, Xuan, Wang, Xiaochen, Zhan, Hongwei, Chen, Yiding, Deng, Yongchuan, and Huang, Jian

Subjects
*BREAST cancer patients, *BREAST cancer diagnosis, *BREAST imaging, *BREAST cancer treatment, *BREAST cancer magnetic resonance imaging, *DUCTAL carcinoma, *BREAST surgery, *ADENOCARCINOMA, *BREAST, *MAMMOGRAMS, *BREAST tumors, *COMPARATIVE studies, *GAMMA rays, *IMMUNOHISTOCHEMISTRY, *MAGNETIC resonance imaging, *RESEARCH methodology, *MEDICAL cooperation, *ORGANIC compounds, *RADIONUCLIDE imaging, *RADIOPHARMACEUTICALS, *RESEARCH, *ULTRASONIC imaging, *EVALUATION research, *RETROSPECTIVE studies, *EARLY detection of cancer, BREAST physiology
Abstract

Background: Diagnosing breast cancer during the early stage may be helpful for decreasing cancer-related mortality. In Western developed countries, mammographies have been the gold standard for breast cancer detection. However, Chinese women usually have denser and smaller-sized breasts compared to Caucasian women, which decreases the diagnostic accuracy of mammography. However, breast specific gamma imaging, a type of molecular functional breast imaging, has been used for the accurate diagnosis of breast cancer and is not influenced by breast density. Our objective was to analyze the breast specific gamma imaging (BSGI) diagnostic value for Chinese women.Methods: During a 2-year period, 357 women were diagnosed and treated at our oncology department and received BSGI in addition to mammography (MMG), ultrasound (US) and magnetic resonance imaging (MRI) for diagnostic assessment. We investigated the sensitivity and specificity of each method of detection and compared the biological profiles of the four imaging methods.Results: A total of 357 women received a final surgical pathology diagnosis, with 168 malignant diseases (58.5 %) and 119 benign diseases (41.5 %). Of these, 166 underwent the four imaging tests preoperatively. The sensitivity of BSGI was 80.35 and 82.14 % by US, 75.6 % by MMG, and 94.06 % by MRI. Furthermore, the breast cancer diagnosis specificity of BSGI was high (83.19 % vs. 77.31 % vs. 66.39 % vs. 67.69 %, respectively). The BSGI diagnostic sensitivity for mammographic breast density in women was superior to mammography and more sensitive for non-luminal A subtypes (luminal A vs. non-luminal A, 68.63 % vs. 88.30 %).Conclusions: BSGI may help improve the ability to diagnose early stage breast cancer for Chinese women, particularly for ductal carcinoma in situ (DCIS), mammographic breast density and non-luminal A breast cancer. [ABSTRACT FROM AUTHOR]

Published
2016
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