28 results on '"Jesús, S."'
Search Results
2. A new challenge for data analytics: transposons
- Author
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Wellinger, Ralf E. and Aguilar–Ruiz, Jesús S.
- Published
- 2022
- Full Text
- View/download PDF
3. Primary ovarian endometrioid stromal sarcoma presenting with reno-ureteral colic
- Author
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Moral, Ana Isabel Bueno, Jiménez, José Carlos Vilches, Bañón, Carmen Martínez, Díaz Huesca, Manuel Jesús, González, Miriam Valenzuela, and López, Jesús S. Jiménez
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- 2022
- Full Text
- View/download PDF
4. Diphyllobothrium sprakeri n. sp. (Cestoda: Diphyllobothriidae): a hidden broad tapeworm from sea lions off North and South America
- Author
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Hernández-Orts, Jesús S., Kuzmina, Tetiana A., Gomez-Puerta, Luis A., and Kuchta, Roman
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- 2021
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- View/download PDF
5. New surgical realities: implementation of an enhanced recovery after surgery protocol for gynecological laparoscopy—a prospective study
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Jimenez, Jose Carlos Vilches, Serrano, Beatriz Tripiana, Muñoz, Emilia Villegas, Pérez, Belinda Sanchez, and Jimenez Lopez, Jesús S.
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- 2021
- Full Text
- View/download PDF
6. Diagnostic challenges: low-grade adenosarcoma on deep endometriosis
- Author
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Vilches Jimenez, Jose Carlos, Villegas Muñoz, Emilia, González Poveda, Iván, Santos Lorente, David, Sanchez Pérez, Belinda, and Jimenez Lopez, Jesús S.
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- 2019
- Full Text
- View/download PDF
7. Pairwise gene GO-based measures for biclustering of high-dimensional expression data
- Author
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Nepomuceno, Juan A., Troncoso, Alicia, Nepomuceno-Chamorro, Isabel A., and Aguilar-Ruiz, Jesús S.
- Published
- 2018
- Full Text
- View/download PDF
8. A new challenge for data analytics: transposons
- Author
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Wellinger, Ralf Erik, Aguilar-Ruiz, Jesús S., Wellinger, Ralf Erik, and Aguilar-Ruiz, Jesús S.
- Abstract
The evolution of the Data Analytics field, both in its scientific dimension, i.e. Data Analytics Science (research and development of machine learning techniques), and in its engineering extension, i.e. Data Analytics Engineering (analysis, design, implementation and deployment of Data Analytics projects), has been uneven over the last four decades and, to a large extent, conditioned by the growth rate on the capacity to generate information. The global volume of information reaching the Internet has been steadily increasing, far exceeding linearity over the last decades (currently, global traffic is around 2EB/day). Apart from the recent technological development, which includes the widespread use of mobile devices, the reduction in cost of sensors, or the improved performance of IT infrastructures, all of which have led to massive data generation, we find a reliable picture of how the typology of data has evolved in the datasets that have been used by the scientific community as a basis for the comparative analysis of innovative algorithmic approaches in Data Analytics.
- Published
- 2022
9. A new challenge for data analytics: transposons
- Author
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Jesús S. Aguilar-Ruiz, Ralf Erik Wellinger, and Universidad de Sevilla. Departamento de Genética
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Computational Mathematics ,Computational Theory and Mathematics ,Genetics ,Molecular Biology ,Biochemistry ,Computer Science Applications - Abstract
The evolution of the Data Analytics field, both in its scientific dimension, i.e. Data Analytics Science (research and development of machine learning techniques), and in its engineering extension, i.e. Data Analytics Engineering (analysis, design, implementation and deployment of Data Analytics projects), has been uneven over the last four decades and, to a large extent, conditioned by the growth rate on the capacity to generate information. The global volume of information reaching the Internet has been steadily increasing, far exceeding linearity over the last decades (currently, global traffic is around 2EB/day). Apart from the recent technological development, which includes the widespread use of mobile devices, the reduction in cost of sensors, or the improved performance of IT infrastructures, all of which have led to massive data generation, we find a reliable picture of how the typology of data has evolved in the datasets that have been used by the scientific community as a basis for the comparative analysis of innovative algorithmic approaches in Data Analytics.
- Published
- 2022
10. Diagnostic challenges: low-grade adenosarcoma on deep endometriosis
- Author
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David Lorente, Iván González Poveda, Emilia Villegas Muñoz, Belinda Sanchez Pérez, Jose Carlos Vilches Jimenez, and Jesús S Jiménez López
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Adult ,medicine.medical_specialty ,Uterus ,Endometriosis ,Extrauterine ,Ovary ,Case Report ,Malignancy ,Pelvic Pain ,lcsh:Gynecology and obstetrics ,Diagnosis, Differential ,medicine ,Humans ,Laparoscopy ,lcsh:RG1-991 ,Ovarian Neoplasms ,Tumor ,medicine.diagnostic_test ,business.industry ,Deep endometriosis ,Adenosarcoma ,lcsh:Public aspects of medicine ,Pelvic pain ,Obstetrics and Gynecology ,lcsh:RA1-1270 ,General Medicine ,medicine.disease ,medicine.anatomical_structure ,Reproductive Medicine ,Uterine Neoplasms ,Female ,Radiology ,medicine.symptom ,Neoplasm Grading ,business - Abstract
Background Müllerian adenosarcoma is a rare malignancy. These tumors occur mainly in the uterus, but also in extrauterine locations, usually related to endometriosis. Because of their rarity, there is limited data on optimal management strategies. Case presentation We present a 44-year-old woman with a history of endometriosis who consults for chronic pelvic pain. In the imaging tests, a heterogeneous mass is observed that impresses endometriosis, encompassing the uterus and left appendage. Surgery is performed by finding an extrauterine adenosarcoma that affected the uterus, ovary and bladder wall. Conclusion This is a rare case but should be considered in a patient with atypical clinical characteristics or preoperative pathology, so we show the diagnostic and therapeutic strategies carried out for the resolution of the case.
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- 2019
11. Vaginal metastasis as the initial presentation of leiomyosarcoma: a case report
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Cecilia Villalain-Gonzalez, Alvaro Tejerizo-Garcia, Jesús S Jiménez-López, Ma. Reyes Oliver-Perez, Patricia Lopez-Garcia, and Gregorio Lopez-Gonzalez
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Leiomyosarcoma ,Cancer Research ,Pathology ,medicine.medical_specialty ,Vaginal Neoplasms ,medicine.medical_treatment ,Histopathology ,Vaginal neoplasm ,Case Report ,lcsh:RC254-282 ,Uterine neoplasm ,030218 nuclear medicine & medical imaging ,Metastasis ,03 medical and health sciences ,0302 clinical medicine ,Case report ,Genetics ,medicine ,Humans ,Uterine Neoplasm ,Uterine leiomyoma ,Hysterectomy ,Uterine sarcoma ,Leiomyoma ,business.industry ,Middle Aged ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,medicine.disease ,Immunohistochemistry ,Adjuvant chemotherapy ,body regions ,Oncology ,Gynecology ,Chemotherapy, Adjuvant ,030220 oncology & carcinogenesis ,Uterine Neoplasms ,Female ,Vaginal Cyst ,business - Abstract
Background Uterine leiomyosarcomas are very rare and highly aggressive tumors that have a high rate of recurrence and poor prognosis, even when early diagnosed. Due to their relative rarity, there is limited research on optimal management strategies. Case presentation A 60-year-old woman with a history of an asymptomatic uterine leiomyoma presented in October 2015 with postmenopausal bleeding and a friable vaginal cyst that bled when palpated. A partial cystectomy was performed, and malignant-like cystic and solid components were identified. Histopathology diagnosed an unclassifiable malignant epithelioid tumor. Subsequent imaging studies identified a malignant uterine tumor, a metabolically active vaginal lesion, and two benign leiomyomas. An anterior pelvic exenteration (colpectomy, hysterectomy, bilateral adnexectomy, total cystectomy, and cutaneous ureteroileostomy ad modum Bricker) were performed by laparotomy in March 2016. Examination of the surgical specimens identified a 75 × 75-mm leiomyoma, an 80 × 30-mm infiltrating mesenchymal uterine lesion with vascular invasion and tumor emboli, and a 60 × 30-mm perivascular vaginal tumor. Immunohistochemistry indicated a phenotypic transition from a uterine leiomyosarcoma to a vaginal epithelioid lesion; marker expression changed from the uterine tumor actin+/desmin+/caldesmon+/CD10− phenotype, through the tumor emboli, to an actin−/desmin−/caldesmon−/CD10+ phenotype in the vaginal lesion. A high-grade uterine mesenchymal tumor and vaginal metastasis were diagnosed. Adjuvant chemotherapy with docetaxel, gemcitabine, and doxorubicin commenced in May 2016 and treatment has been well tolerated. Conclusions Differentiating leiomyosarcoma from leiomyoma is challenging and few tools other than microscopic evaluation are available. Vaginal compromise in leiomyosarcoma usually results from tumor extension, not hematogenous metastasis. A vaginal metastasis is a very rare initial presentation. We have found only two cases like this described on published literature. The atypical clinical and histological presentation in our case complicated diagnosis and delayed treatment. An early diagnosis and complete surgical clearance gives the best chance of survival, and imaging tools should be applied early in instances of new suspicious malignant lesions.
- Published
- 2017
12. Psoas haematoma as a complication of Veress needle insertion: description of a case and literature review
- Author
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Jesús S Jiménez-López, Gregorio Lopez-Gonzalez, Diana García-Alcázar, Emma Batllori-Badia, Estela Lorenzo-Hernando, Jose L Muñoz-Gonzalez, Leticia Muñoz-Hernando, and Beatriz García-Chapinal
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Laparoscopic surgery ,Adult ,medicine.medical_specialty ,Haematoma ,Accidental vascular injury ,medicine.medical_treatment ,Case Report ,Psoas Muscles ,Pseudoaneurysm ,Hematoma ,medicine ,Humans ,Embolization ,Laparoscopy ,Veress needle ,Vertebral Artery ,Lumbar Vertebrae ,medicine.diagnostic_test ,business.industry ,General Medicine ,medicine.disease ,Embolization, Therapeutic ,Surgery ,Great vessels ,Needles ,Female ,business ,Psoas ,Aneurysm, False - Abstract
Background In terms of gynaecological laparoscopic surgery, major complications affecting great vessels, and especially the retroperitoneal ones, are unusual. Case presentation We introduce a case of a retroperitoneal haematoma associated with psoas muscle pseudoaneurysm, as a side effect of Veress needle insertion, during laparoscopic surgery. Such complication was managed conservatively at first, requiring finally arterial embolisation. Conclusion Even though potential complications associated with laparoscopic surgery are infrequent, they must not be underestimated, and in some cases might need a multidisciplinary management.
- Published
- 2014
13. Vaginal metastasis as the initial presentation of leiomyosarcoma: a case report.
- Author
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Villalaín-González, Cecilia, Tejerizo-García, Álvaro, Lopez-Garcia, Patricia, López-González, Gregorio, Oliver-Perez, Ma. Reyes, and Jiménez-López, Jesús S.
- Subjects
VAGINAL tumors ,LEIOMYOSARCOMA ,METASTASIS ,PROGNOSIS ,POSTMENOPAUSE ,COMBINED modality therapy ,TUMOR treatment ,UTERINE tumors ,THERAPEUTICS - Abstract
Background: Uterine leiomyosarcomas are very rare and highly aggressive tumors that have a high rate of recurrence and poor prognosis, even when early diagnosed. Due to their relative rarity, there is limited research on optimal management strategies.Case Presentation: A 60-year-old woman with a history of an asymptomatic uterine leiomyoma presented in October 2015 with postmenopausal bleeding and a friable vaginal cyst that bled when palpated. A partial cystectomy was performed, and malignant-like cystic and solid components were identified. Histopathology diagnosed an unclassifiable malignant epithelioid tumor. Subsequent imaging studies identified a malignant uterine tumor, a metabolically active vaginal lesion, and two benign leiomyomas. An anterior pelvic exenteration (colpectomy, hysterectomy, bilateral adnexectomy, total cystectomy, and cutaneous ureteroileostomy ad modum Bricker) were performed by laparotomy in March 2016. Examination of the surgical specimens identified a 75 × 75-mm leiomyoma, an 80 × 30-mm infiltrating mesenchymal uterine lesion with vascular invasion and tumor emboli, and a 60 × 30-mm perivascular vaginal tumor. Immunohistochemistry indicated a phenotypic transition from a uterine leiomyosarcoma to a vaginal epithelioid lesion; marker expression changed from the uterine tumor actin+/desmin+/caldesmon+/CD10- phenotype, through the tumor emboli, to an actin-/desmin-/caldesmon-/CD10+ phenotype in the vaginal lesion. A high-grade uterine mesenchymal tumor and vaginal metastasis were diagnosed. Adjuvant chemotherapy with docetaxel, gemcitabine, and doxorubicin commenced in May 2016 and treatment has been well tolerated.Conclusions: Differentiating leiomyosarcoma from leiomyoma is challenging and few tools other than microscopic evaluation are available. Vaginal compromise in leiomyosarcoma usually results from tumor extension, not hematogenous metastasis. A vaginal metastasis is a very rare initial presentation. We have found only two cases like this described on published literature. The atypical clinical and histological presentation in our case complicated diagnosis and delayed treatment. An early diagnosis and complete surgical clearance gives the best chance of survival, and imaging tools should be applied early in instances of new suspicious malignant lesions. [ABSTRACT FROM AUTHOR]- Published
- 2017
- Full Text
- View/download PDF
14. Cross-sectional study about primary health care professionals views on the inclusion of the vaccine against human papillomavirus in the vaccine schedules.
- Author
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Oliver Pérez, M. Reyes, Bravo Violeta, Victoria, Vazquez del Campo, Ana, Ruiz, Cristina, Yáñez Castaño, Sonia, Pérez Conde, Laura P., and Jiménez López, Jesús S.
- Subjects
CHI-squared test ,IMMUNIZATION ,MEDLINE ,ONLINE information services ,PAPILLOMAVIRUSES ,PRIMARY health care ,SURVEYS ,TIME ,CERVIX uteri tumors ,SYSTEMATIC reviews ,CROSS-sectional method ,DATA analysis software - Abstract
Background: Although the inclusion of the HPV vaccine has been registered in Spain since 2007, vaccination rates are lower than expected. The patients wish to be vaccinated is heavily influenced by information they have received from many source. The Knowledge of primary health care professionals affects the information provided to patients and is fundamental in the decision making. The aim of this study is to assess the opinions of primary health care professionals on the vaccine against HPV and their knowledge about HPV infection and its links to with gynecological and oropharyngeal cancer. Methods: Cross-sectional study. A 19-item survey was drawn up. It included questions on basic aspects of HPV infection and marketed vaccines, personal opinion about the inclusion in the immunization schedules and their level of prescription and recommendation to patients in their clinical practice. From October 2013 to December 2013, 607 surveys were distributed among 20 primary health centers affiliated to the University Hospital 12 de Octubre. The results were analyzed using SPSS statistical package. Results: One hundred sixty four successfully completed surveys were obtained for analysis. 89 % of the professionals knew about the relationship between HPV infection and cervical cancer, 57.3 % did not know any of the serotypes against which vaccines are targeted; 40.4 % believed that there is insufficient data to support the commercialization of the vaccines. Of these, 65.7 % argue that there is no data of its long-term effectiveness, 13.4 % that there is no data as to its side effects, 13.4 % believed that the cost effectiveness is not worthwhile. Conclusions: There is a strong controversy among health professionals regarding the marketing and inclusion of HPV vaccine in immunization schedules. However, the knowledge of the primary care health professionals on key aspects of infection and vaccine protection are insufficient. The training of professionals in vaccination, cervical pathology and HPV infection should be improved to provide objective information on the use as this vaccine for patients. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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15. Endometriosis node in Gynaecologic scars: A study of 17 patients and the diagnostic considerations in clinical experience in tertiary care center.
- Author
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Vellido-Cotelo, Rocío, Muñoz-González, Jose L., Oliver-Pérez, Maria R., de la Hera-Lázaro, Cristina, Almansa-González, Cristina, Pérez-Sagaseta, Concepción, and Jiménez-López, Jesús S
- Subjects
ENDOMETRIOSIS ,GYNECOLOGY ,GRANULATION tissue ,ENDOMETRIUM ,PELVIC diseases - Abstract
Background: Endometriosis nodes are observed in extra pelvic locations, particularly in gynaecological scars, with the abdominal wall being one of the most frequent locations. The main objective of the study is to review patient characteristics of cases of endometriosis nodes in gynaecological scars. Methods: A retrospective, observational and descriptive study with a cohort of patients from Hospital 12 de Octubre was conducted from January 2000 to January 2012. We analysed all of the patients who presented with an endometriosis node in a gynaecological scar presentation who had undergone surgery in that period. Descriptive data were collected and analysed. Results: A total of 17 patients with an anatomopathological diagnosis of an endometriosis node in a gynaecological scar were found. The following variables were studied: the age at diagnosis (32.5 years +/- 5.5 years), personal and obstetric history, time from surgery to diagnosis (4.2 years +/- 3.4 years), symptoms (a painful mass that grows during menstruation is the most frequent symptom in our patients), technical analyses by computed tomography (CT), magnetic resonance (MR) or fine needle aspiration (FNA) (77% of the patients), node size (2.5 cm +/- 1.1 cm) and location (caesarean scar, 82%; episiotomy scar, 11.7%; and laparoscopic surgery port, 5.8%), involvement of adjacent structures (29% of the patients), treatment (exeresis with a security margin in all the patients) and other endometriosis locations (14% of the patients). Conclusions: A high level of suspicion is required to diagnose gynaecological scar endometriosis, which should be suspected in the differential diagnosis of scar masses in reproductive-aged women. Several theories have been proposed to explain the formation of endometriosis nodes in extrauterine localizations. The two of them that seem to be more plausible are the metaplasia and transport theories. Imaging with ultrasound, CT and MR facilitate the diagnosis. FNA could be used for preoperative diagnosis. Treatment must be by node resection with a security margin. In some cases, surgery could be combined with hormonal treatment. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
16. Psoas haematoma as a complication of Veress needle insertion: description of a case and literature review.
- Author
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García-Alcázar, Diana, García-Chapinal, Beatriz, Batllori-Badia, Emma, López-González, Gregorio, Lorenzo-Hernando, Estela, Jiménez-López, Jesús S., Muñoz-Hernando, Leticia, and Muñoz-González, José Luis
- Subjects
PSOAS muscles ,LAPAROSCOPIC surgery complications ,PSOAS muscle diseases ,FALSE aneurysms ,ELECTROMYOGRAPHY - Abstract
Background In terms of gynaecological laparoscopic surgery, major complications affecting great vessels, and especially the retroperitoneal ones, are unusual. Case presentation We introduce a case of a retroperitoneal haematoma associated with psoas muscle pseudoaneurysm, as a side effect of Veress needle insertion, during laparoscopic surgery. Such complication was managed conservatively at first, requiring finally arterial embolisation. Conclusion Even though potential complications associated with laparoscopic surgery are infrequent, they must not be underestimated, and in some cases might need a multidisciplinary management. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
17. Description, microhabitat selection and infection patterns of sealworm larvae (Pseudoterranova decipiens species complex, nematoda: ascaridoidea) in fishes from Patagonia, Argentina.
- Author
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Hernández-Orts, Jesús S, Aznar, Francisco J., Blasco-Costa, Isabel, García, Néstor A ., Víllora-Montero, María, Crespo, Enrique A., Raga, Juan A., and Montero, Francisco E.
- Subjects
- *
PSEUDOTERRANOVA , *SEALWORM , *ECOLOGICAL niche , *MARINE fishes , *INFECTIONS in fish , *DISEASES - Abstract
Background: Third-stage larvae of the Pseudoterranova decipiens species complex (also known as sealworms) have been reported in at least 40 marine fish species belonging to 21 families and 10 orders along the South American coast. Sealworms are a cause for concern because they can infect humans who consume raw or undercooked fish. However, despite their economic and zoonotic importance, morphological and molecular characterization of species of Pseudoterranova in South America is still scarce. Methods: A total of 542 individual fish from 20 species from the Patagonian coast of Argentina were examined for sealworms. The body cavity, the muscles, internal organs, and the mesenteries were examined to detect nematodes. Sealworm larvae were removed from their capsules and fixed in 70% ethanol. For molecular identification, partial fragments of the mitochondrial cytochrome c oxidase subunit 1 gene (cox1) were amplified for 10 isolates from 4 fish species. Morphological and morphometric data of sealworms were also obtained. Results: A total of 635 larvae were collected from 12 fish species. The most infected fish was Prionotus nudigula, followed by Percophis brasiliensis, Acanthistius patachonicus, Paralichthys isosceles, and Pseudopercis semifasciata. Sequences obtained for the cox1 of sealworms from A. patachonicus, P. isosceles, P. brasiliensis and P. nudigula formed a reciprocally monophyletic lineage with published sequences of adult specimens of Pseudoterranova cattani from the South American sea lion Otaria flavescens, and distinct from the remaining 5 species of Pseudoterranova. A morphological description, including drawings and scanning electron microscopy photomicrographs of these larvae is provided. Sealworms collected from Argentinean fishes did not differ in their diagnostic traits from the previously described larvae of P. cattani. However a discriminant analysis suggests that specimens from P. nudigula were significantly larger than those from other fishes. Most of the sealworms were collected encapsulated from the muscles and, to a lesser degree, from the mesenteries and the liver. Conclusions: We provided the first molecular identification, morphological description and microhabitat characterization of sealworm larvae from the Argentinean Patagonian coast. We also reported the infection levels of sealworms on 20 fish species in order to elucidate the life cycle of these nematodes in this area. [ABSTRACT FROM AUTHOR]
- Published
- 2013
- Full Text
- View/download PDF
18. Configurable pattern-based evolutionary biclustering of gene expression data.
- Author
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Pontes, Beatriz, Giráldez, Raúl, and Aguilar-Ruiz, Jesús S.
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GENE expression ,CLUSTER analysis (Statistics) ,DNA microarrays ,HEURISTIC ,EVOLUTIONARY algorithms ,GENE ontology - Abstract
Background: Biclustering algorithms for microarray data aim at discovering functionally related gene sets under different subsets of experimental conditions. Due to the problem complexity and the characteristics of microarray datasets, heuristic searches are usually used instead of exhaustive algorithms. Also, the comparison among different techniques is still a challenge. The obtained results vary in relevant features such as the number of genes or conditions, which makes it difficult to carry out a fair comparison. Moreover, existing approaches do not allow the user to specify any preferences on these properties. Results: Here, we present the first biclustering algorithm in which it is possible to particularize several biclusters features in terms of different objectives. This can be done by tuning the specified features in the algorithm or also by incorporating new objectives into the search. Furthermore, our approach bases the bicluster evaluation in the use of expression patterns, being able to recognize both shifting and scaling patterns either simultaneously or not. Evolutionary computation has been chosen as the search strategy, naming thus our proposal Evo-Bexpa (Evolutionary Biclustering based in Expression Patterns). Conclusions: We have conducted experiments on both synthetic and real datasets demonstrating Evo-Bexpa abilities to obtain meaningful biclusters. Synthetic experiments have been designed in order to compare Evo-Bexpa performance with other approaches when looking for perfect patterns. Experiments with four different real datasets also confirm the proper performing of our algorithm, whose results have been biologically validated through Gene Ontology. [ABSTRACT FROM AUTHOR]
- Published
- 2013
- Full Text
- View/download PDF
19. The embryonic phase and its implication in the hatchling size and condition of Atlantic bobtail squid Sepiola atlantica.
- Author
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Rodrigues, Marcelo, Guerra, Angel, and Troncoso, Jesús S.
- Subjects
SEPIOLIDAE ,CEPHALOPODA ,EMBRYOLOGY ,INVERTEBRATES ,MARINE invertebrates - Abstract
Early life stages of cephalopods are somewhat complex due to the life history strategy or species specificity of generalized ontogenetic patterns and processes. This work aimed to determine the time length of embryonic development at different temperatures, and if the egg size is a determinant of hatchling size in Sepiola atlantica d′Orbigny, 1839-1842. Successful hatching occurred in 98.5-100% of the eggs for each female. As seen in other coleoid cephalopods, temperature determines the amount of time for embryonic development in S. atlantica, and the obtained data were very similar to other coleoid cephalopods. Developmental times for temperatures at 13 ± 0.4°C, 18 ± 0.3°C and 16.4 ± 1.1°C were 61.8 ± 3.8, 22.6 ± 1.7 and 40.1 ± 4.8 days. The duration of embryonic development and hatchling mantle length was not strictly related. The egg volume was positively related to hatchling mantle length. Our results provide new records on the duration of embryogenesis and other information on reproductive patterns in this species. Some hatching and post-hatching behaviour are shown and discussed. [ABSTRACT FROM AUTHOR]
- Published
- 2011
- Full Text
- View/download PDF
20. Spawning strategy in Atlantic bobtail squid Sepiola atlantica (Cephalopoda: Sepiolidae).
- Author
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Rodrigues, Marcelo, Garcí, Manuel E., Troncoso, Jesús S., and Guerra, Ángel
- Subjects
SEPIOLIDAE ,SPAWNING ,REPRODUCTION ,ANIMAL morphology ,EGGS - Abstract
This study aimed to determine the spawning strategy in the Atlantic bobtail squid Sepiola atlantica, in order to add new information to the knowledge of its reproductive strategy. A total of 12 females that spawned in aquaria were examined. Characteristics of the reproductive traits and egg clutches were similar to those of other known Sepiolidae. Clutch size varied from 31 up to 115 eggs. Females of this species had incorporated up to 1.58 times of their body weight into laid eggs. The size of laid eggs showed a positive correlation with maternal body size, supporting the idea that female size is a determinant of egg size. Our data suggest that S. atlantica is an intermittent terminal spawner , and that its spawning strategy comprises group-synchronous ovary maturation, multiple egg laying, and deposition of egg clutches in different locations. The obtained data provide insights for future comparative studies on reproductive allocation. [ABSTRACT FROM AUTHOR]
- Published
- 2011
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- View/download PDF
21. Biclustering of Gene Expression Data by Correlation-Based Scatter Search.
- Author
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Nepomuceno, Juan A., Troncoso, Alicia, and Aguilar-Ruiz, Jesús S.
- Subjects
MICROARRAY technology ,FUNCTIONAL genomics ,GENE expression ,GENETIC regulation ,STATISTICAL correlation ,YEAST ,DATABASES - Abstract
Background: The analysis of data generated by microarray technology is very useful to understand how the genetic information becomes functional gene products. Biclustering algorithms can determine a group of genes which are co-expressed under a set of experimental conditions. Recently, new biclustering methods based on metaheuristics have been proposed. Most of them use the Mean Squared Residue as merit function but interesting and relevant patterns from a biological point of view such as shifting and scaling patterns may not be detected using this measure. However, it is important to discover this type of patterns since commonly the genes can present a similar behavior although their expression levels vary in different ranges or magnitudes. Methods: Scatter Search is an evolutionary technique that is based on the evolution of a small set of solutions which are chosen according to quality and diversity criteria. This paper presents a Scatter Search with the aim of finding biclusters from gene expression data. In this algorithm the proposed fitness function is based on the linear correlation among genes to detect shifting and scaling patterns from genes and an improvement method is included in order to select just positively correlated genes. Results: The proposed algorithm has been tested with three real data sets such as Yeast Cell Cycle dataset, human B-cells lymphoma dataset and Yeast Stress dataset, finding a remarkable number of biclusters with shifting and scaling patterns. In addition, the performance of the proposed method and fitness function are compared to that of CC, OPSM, ISA, BiMax, xMotifs and Samba using Gene the Ontology Database. [ABSTRACT FROM AUTHOR]
- Published
- 2011
- Full Text
- View/download PDF
22. Identifying comorbidities and lifestyle factors contributing to the cognitive profile of early Parkinson's disease.
- Author
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Martínez-Horta S, Bejr-Kasem H, Horta-Barba A, Pascual-Sedano B, Santos-García D, de Deus-Fonticoba T, Jesús S, Aguilar M, Planellas L, García-Caldentey J, Caballol N, Vives-Pastor B, Hernández-Vara J, Cabo-Lopez I, López-Manzanares L, González-Aramburu I, Ávila-Rivera MA, Catalán MJ, López-Díaz LM, Puente V, García-Moreno JM, Borrué C, Solano-Vila B, Álvarez-Sauco M, Vela L, Escalante S, Cubo E, Carrillo-Padilla F, Martínez-Castrillo JC, Sánchez-Alonso P, Alonso-Losada MG, López-Ariztegui N, Gastón I, Blázquez-Estrada M, Seijo-Martínez M, Rúiz-Martínez J, Valero-Merino C, Kurtis M, de Fábregues-Boixar O, González-Ardura J, Prieto-Jurczynska C, Martinez-Martin P, Mir P, and Kulisevsky J
- Subjects
- Cognition, Humans, Life Style, Neuropsychological Tests, Cognitive Dysfunction epidemiology, Dementia, Parkinson Disease complications, Parkinson Disease epidemiology
- Abstract
Background: Identifying modifiable risk factors for cognitive impairment in the early stages of Parkinson's disease (PD) and estimating their impact on cognitive status may help prevent dementia (PDD) and the design of cognitive trials., Methods: Using a standard approach for the assessment of global cognition in PD and controlling for the effects of age, education and disease duration, we explored the associations between cognitive status, comorbidities, metabolic variables and lifestyle variables in 533 PD participants from the COPPADIS study., Results: Among the overall sample, 21% of participants were classified as PD-MCI (n = 114) and 4% as PDD (n = 26). The prevalence of hypertension, diabetes and dyslipidemia was significantly higher in cognitively impaired patients while no between-group differences were found for smoking, alcohol intake or use of supplementary vitamins. Better cognitive scores were significantly associated with regular physical exercise (p < 0.05) and cognitive stimulation (< 0.01). Cognitive performance was negatively associated with interleukin 2 (Il2) (p < 0.05), Il6 (p < 0.05), iron (p < 0.05), and homocysteine (p < 0.005) levels, and positively associated with vitamin B12 levels (p < 0.005)., Conclusions: We extend previous findings regarding the positive and negative influence of various comorbidities and lifestyle factors on cognitive status in early PD patients, and reinforce the need to identify and treat potentially modifiable variables with the intention of exploring the possible improvement of the global cognitive status of patients with PD., (© 2021. The Author(s).)
- Published
- 2021
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23. Mesonephric adenocarcinoma of the cervix: a case report with a three-year follow-up, lung metastases, and next-generation sequencing analysis.
- Author
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Montalvo N, Redrobán L, and Galarza D
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- Adenocarcinoma diagnosis, Adenocarcinoma secondary, Cervix Uteri pathology, Female, High-Throughput Nucleotide Sequencing, Humans, Lung Neoplasms diagnosis, Lung Neoplasms secondary, Mesonephroma diagnosis, Mesonephroma secondary, Middle Aged, Mutation, Sequence Analysis, DNA, Uterine Cervical Neoplasms diagnosis, Uterine Cervical Neoplasms pathology, Adenocarcinoma genetics, Lung Neoplasms genetics, Mesonephroma genetics, Uterine Cervical Neoplasms genetics, beta Catenin genetics
- Abstract
Background: Mesonephric adenocarcinoma (MNAC) is a rare tumor of the female genital tract, which originates from mesonephric duct remnants. Its diagnosis is pathologically challenging, because MNAC may exhibit a mixture of morphological patterns that complicates the differential diagnosis., Case Presentation: The patient in this case was a 48-year-old woman with a polypoid mass protruding into the endocervical canal. The patient underwent a total hysterectomy outside the institution. During biopsy, the mass showed a cerebroid aspect. Histological study revealed a tumor with a predominantly tubular and ductal growth pattern. The immunoprofile showed negative staining for calretinin, carcinoembryonic antigen (CEAm), estrogen receptors (ER), and progesterone receptors (PR), and positive staining for CD10, p16, and PAX2. The Ki-67 score was 46%. Using a next-generation sequencing assay, we documented genomic alterations in KRAS and CTNNB1, low tumor mutation burden (TMB), and an absence of microsatellite instability. In addition, gain of the long arm of chromosome 1 (1q) was also documented using chomogenic in situ hybridization (CISH). Three years later, the patient presented pulmonary nodules in the lingula and left basal lobe that were resected by thoracotomy. The histopathologic study of the pulmonary nodules confirmed the presence of metastases., Conclusion: Carcinomas of mesonephric origin are among the rarest subtypes of cervical tumors. We report the first case of mesonephric adenocarcinoma of the cervix with lung metastases showing a CTNNB1 gene mutation.
- Published
- 2019
- Full Text
- View/download PDF
24. Cross-sectional study about primary health care professionals views on the inclusion of the vaccine against human papillomavirus in the vaccine schedules.
- Author
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Pérez MR, Violeta VB, Del Campo AV, Ruiz C, Castaño SY, Conde LP, and López JS
- Abstract
Background: Although the inclusion of the HPV vaccine has been registered in Spain since 2007, vaccination rates are lower than expected. The patients wish to be vaccinated is heavily influenced by information they have received from many source. The Knowledge of primary health care professionals affects the information provided to patients and is fundamental in the decision making. The aim of this study is to assess the opinions of primary health care professionals on the vaccine against HPV and their knowledge about HPV infection and its links to with gynecological and oropharyngeal cancer., Methods: Cross-sectional study. A 19-item survey was drawn up. It included questions on basic aspects of HPV infection and marketed vaccines, personal opinion about the inclusion in the immunization schedules and their level of prescription and recommendation to patients in their clinical practice. From October 2013 to December 2013, 607 surveys were distributed among 20 primary health centers affiliated to the University Hospital 12 de Octubre. The results were analyzed using SPSS statistical package., Results: One hundred sixty four successfully completed surveys were obtained for analysis. 89 % of the professionals knew about the relationship between HPV infection and cervical cancer, 57.3 % did not know any of the serotypes against which vaccines are targeted; 40.4 % believed that there is insufficient data to support the commercialization of the vaccines. Of these, 65.7 % argue that there is no data of its long-term effectiveness, 13.4 % that there is no data as to its side effects, 13.4 % believed that the cost effectiveness is not worthwhile., Conclusions: There is a strong controversy among health professionals regarding the marketing and inclusion of HPV vaccine in immunization schedules. However, the knowledge of the primary care health professionals on key aspects of infection and vaccine protection are insufficient. The training of professionals in vaccination, cervical pathology and HPV infection should be improved to provide objective information on the use as this vaccine for patients.
- Published
- 2015
- Full Text
- View/download PDF
25. Incomplete duplication of a lower extremity (polymelia): a case report.
- Author
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Montalvo N, Redrobán L, and Espín VH
- Subjects
- Humans, Infant, Lower Extremity Deformities, Congenital surgery, Male, Thigh abnormalities, Thigh pathology, Thigh surgery, Lower Extremity Deformities, Congenital pathology
- Abstract
Introduction: Polymelia, or congenital duplication of a limb, is an extremely rare entity in humans, with few cases reported in the literature., Case Presentation: We present the case of a six-month-old Hispanic boy born with a lower limb bud on the left posterior thigh., Conclusion: The infant had a favorable outcome and evolution after surgical treatment of his supernumerary limb, with no after-effects or impairment whatsoever.
- Published
- 2014
- Full Text
- View/download PDF
26. Traditional serrated adenoma of the sigmoid colon with osseous metaplasia: a case report.
- Author
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Montalvo NF, Beltrán JN, and Redrobán LA
- Abstract
Introduction: Osseous metaplasia in the gastrointestinal tract is a rare phenomenon., Case Presentation: We present the case of a 62-year-old Hispanic man with two colonic polypoid lesions, one of which, upon resection and histopathological examination, was found to be a traditional serrated adenoma with a focus of stromal osseous metaplasia., Conclusions: Our patient's case is the third report of stromal osseous metaplasia in a traditional serrated adenoma of the sigmoid colon.
- Published
- 2012
- Full Text
- View/download PDF
27. GO-based functional dissimilarity of gene sets.
- Author
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Díaz-Díaz N and Aguilar-Ruiz JS
- Subjects
- Algorithms, Databases, Genetic, Genes, Humans, ROC Curve, Semantics, Unified Medical Language System, Proteins genetics, Saccharomyces cerevisiae genetics, Vocabulary, Controlled
- Abstract
Background: The Gene Ontology (GO) provides a controlled vocabulary for describing the functions of genes and can be used to evaluate the functional coherence of gene sets. Many functional coherence measures consider each pair of gene functions in a set and produce an output based on all pairwise distances. A single gene can encode multiple proteins that may differ in function. For each functionality, other proteins that exhibit the same activity may also participate. Therefore, an identification of the most common function for all of the genes involved in a biological process is important in evaluating the functional similarity of groups of genes and a quantification of functional coherence can helps to clarify the role of a group of genes working together., Results: To implement this approach to functional assessment, we present GFD (GO-based Functional Dissimilarity), a novel dissimilarity measure for evaluating groups of genes based on the most relevant functions of the whole set. The measure assigns a numerical value to the gene set for each of the three GO sub-ontologies., Conclusions: Results show that GFD performs robustly when applied to gene set of known functionality (extracted from KEGG). It performs particularly well on randomly generated gene sets. An ROC analysis reveals that the performance of GFD in evaluating the functional dissimilarity of gene sets is very satisfactory. A comparative analysis against other functional measures, such as GS2 and those presented by Resnik and Wang, also demonstrates the robustness of GFD.
- Published
- 2011
- Full Text
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28. Filling the gap between biology and computer science.
- Author
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Aguilar-Ruiz JS, Moore JH, and Ritchie MD
- Abstract
This editorial introduces BioData Mining, a new journal which publishes research articles related to advances in computational methods and techniques for the extraction of useful knowledge from heterogeneous biological data. We outline the aims and scope of the journal, introduce the publishing model and describe the open peer review policy, which fosters interaction within the research community.
- Published
- 2008
- Full Text
- View/download PDF
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