1. The role of lncRNAs and circRNAs in the PD-1/PD-L1 pathway in cancer immunotherapy.
- Author
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Jiang, Wenxiao, Pan, Shuya, Chen, Xin, Wang, Zhi-wei, and Zhu, Xueqiong
- Subjects
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PROGRAMMED cell death 1 receptors , *PROGRAMMED death-ligand 1 , *IMMUNE checkpoint proteins , *IMMUNOTHERAPY , *LINCRNA - Abstract
Cancer immunotherapy has recently shown promising antitumor effects in various types of tumors. Among all immune checkpoints, the PD-1/PD-L1 pathway plays an important role in the immune evasion of tumor cells, making it a potent target in antitumor immunity. Accordingly, antibodies targeting the PD-1/PD-L1 pathway have been developed to attack tumor cells; however, resistance to immune therapy remains to be solved. Hence, identification of the underlying modulators of the PD-1/PD-L1 pathway is of significant importance to understand the mechanisms of antitumor immunotherapy. Long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) have been identified to regulate the PD-1/PD-L1 pathway, leading to participation in the immune response and immunotherapy. Therefore, this review focuses on the functions of lncRNAs and circRNAs in regulation of the PD-1/PD-L1 axis in tumorigenesis and tumor progression. We hope this review will stimulate research to supply more precise and effective cancer immune checkpoint therapies for a large number of tumors. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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