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2 results on '"Masashi Miguchi"'

1. Malignant peripheral nerve sheath tumor arising from the greater omentum: Case report

Author

Masashi Miguchi, Manabu Shinomura, Hideki Ohdan, Takao Hinoi, Masakazu Tokunaga, Tomohiro Adachi, Yasuo Kawaguchi, Yuji Takakura, Masazumi Okajima, and Hiroyuki Egi

Subjects
Male, Pathology, medicine.medical_specialty, Exploratory laparotomy, medicine.medical_treatment, lcsh:Surgery, Case Report, Malignant peripheral nerve sheath tumor, Abdominal cavity, lcsh:RC254-282, Nerve Sheath Neoplasms, medicine, Humans, Peritoneal Neoplasms, Pelvis, Aged, business.industry, S100 Proteins, Soft tissue, Anatomy, lcsh:RD1-811, Greater omentum, medicine.disease, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.anatomical_structure, Oncology, Abdomen, Surgery, Desmin, business, Omentum
Abstract

Malignant peripheral nerve sheath tumors (MPNSTs) are rare soft tissue tumors that arise from a peripheral nerve or exhibit nerve sheath differentiation. Most of these tumors arise on the trunk, extremities, or head and neck regions; they are very rarely located in the abdominal cavity. The patient was a 71-year-old man who was referred to our hospital for a mass and pain in the right lower abdomen. Abdominal computed tomography revealed a large (9 × 9 cm), well-circumscribed, lobulated, heterogeneously enhanced mass in the pelvis. Exploratory laparotomy revealed a large mass in the greater omentum, and the tumor was completely excised. Histopathological analysis revealed that the tumor was composed of spindle cells with high mitotic activity. On staining the tumor, positive results were obtained for S-100 but negative results were obtained for c-kit, cluster of differentiation (CD)34, α-smooth muscle actin, and desmin. These findings strongly supported a diagnosis of MPNST primarily arising from the greater omentum. To the best of our knowledge, this is the first reported case of an MPNST arising from the greater omentum. In this report, we have described the case of a patient with an MPNST arising from the greater omentum and have discussed the clinical characteristics and management of MPNSTs.

Published
2011

2. Avoiding restorative proctocolectomy for colorectal cancer in patients with ulcerative colitis based on preoperative diagnosis involving p53 immunostaining: report of a case.

Author

Haruki Sada, Manabu Shimomura, Takao Hinoi, Hiroyuki Egi, Koji Kawaguchi, Takuya Yano, Hiroaki Niitsu, Yasufumi Saitou, Hiroyuki Sawada, Masashi Miguchi, Tomohiro Adachi, and Hideki Ohdan

Subjects
RESTORATIVE proctocolectomy, RECTAL cancer, ULCERATIVE colitis, COLECTOMY, LYMPHADENECTOMY, IMMUNOSTAINING
Abstract

The standard operation for colitic cancer in ulcerative colitis (UC) is restorative proctocolectomy; however, sporadic colorectal cancer (CRC) can coincidentally arise in patients with UC and the optimal procedure remains controversial. Therefore, it is crucial to preoperatively determine whether the CRC in UC is a sporadic or colitic cancer. We report a case of avoiding proctocolectomy for sporadic CRC in a patient with UC based on preoperative diagnosis involving p53 immunostaining. A 73-year-old man with CRC in UC had undergone sigmoid colectomy with lymphadenectomy because of the submucosal deep invasion pathologically after endoscopic mucosal resection. The cancer was diagnosed sporadic cancer preoperatively not only based on the endoscopic, clinical, and histological patterns but also that the colon epithelium was unlikely to develop dysplasia as the circumference and unaffected UC mucosa did not detect p53 protein overexpression. Recent reports have shown that the immunohistochemical detection of p53 protein overexpression can be useful for a differential diagnosis and as a predictor of dysplasia and colitic cancer. The analysis of p53 mutation status based on immunostaining of p53 protein expression in the unaffected UC mucosa can be useful for the decision regarding a surgical procedure for CRC in patients with UC. [ABSTRACT FROM AUTHOR]

Published
2015
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