1. Genetic, hormonal and metabolic aspects of PCOS: an update.
- Author
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De Leo V, Musacchio MC, Cappelli V, Massaro MG, Morgante G, and Petraglia F
- Subjects
- Animals, Female, Hirsutism diagnosis, Hirsutism genetics, Hirsutism metabolism, Humans, Hyperandrogenism diagnosis, Hyperandrogenism genetics, Hyperandrogenism metabolism, Insulin Resistance physiology, Obesity diagnosis, Obesity genetics, Obesity metabolism, Polycystic Ovary Syndrome diagnosis, Epigenesis, Genetic physiology, Gonadal Steroid Hormones genetics, Gonadal Steroid Hormones metabolism, Polycystic Ovary Syndrome genetics, Polycystic Ovary Syndrome metabolism
- Abstract
Polycystic ovary syndrome (PCOS) is a complex endocrine disorder affecting 5-10 % of women of reproductive age. It generally manifests with oligo/anovulatory cycles, hirsutism and polycystic ovaries, together with a considerable prevalence of insulin resistance. Although the aetiology of the syndrome is not completely understood yet, PCOS is considered a multifactorial disorder with various genetic, endocrine and environmental abnormalities. Moreover, PCOS patients have a higher risk of metabolic and cardiovascular diseases and their related morbidity, if compared to the general population.
- Published
- 2016
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