1. Metabolomics study in severe extracranial carotid artery stenosis
- Author
-
Ming-Shi Shiao, Tsong-Hai Lee, Mei-Ling Cheng, and Chia-Ni Lin
- Subjects
Male ,medicine.medical_specialty ,Magnetic Resonance Spectroscopy ,Homocysteine ,Gastroenterology ,lcsh:RC346-429 ,Choline ,Coronary artery disease ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Risk Factors ,Internal medicine ,Diabetes mellitus ,medicine ,Carotid stenosis ,Outpatient clinic ,Metabolomics ,Humans ,030212 general & internal medicine ,Risk factor ,Stroke ,lcsh:Neurology. Diseases of the nervous system ,medicine.diagnostic_test ,business.industry ,General Medicine ,Middle Aged ,medicine.disease ,Atherosclerosis ,Lipids ,Cerebral Angiography ,Stenosis ,chemistry ,Case-Control Studies ,Neurology (clinical) ,business ,030217 neurology & neurosurgery ,Biomarkers ,Cerebral angiography ,Research Article - Abstract
Background Significant genetic association has been found in patients with severe carotid artery stenosis (CAS). The present study wished to investigate if metabolites may also act as biomarkers for CAS. Methods Consecutive patients with at least one carotid artery stenosis > = 60% on cerebral angiography were prospectively recruited from May 2007 to January 2016. Normal controls were recruited from outpatient clinic who had no stroke and coronary artery disease (CAD) history, and the brain magnetic resonance or computed tomographic angiography showed bilateral CAS
- Published
- 2019