Author: "Melén, E." / Publisher: biomed central - Searchworks@Jio Institute Digital Library Search Results

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20 results on '"Melén, E."'

1. Optimizing care for children with difficult-to-treat and severe asthma through specialist paediatric asthma centres: expert practical experience and advice

Author: Pijnenburg, M. W., Rubak, S., Skjerven, H. O., Verhulst, S., Elenius, V., Hugen, C., Jauhola, O., Kempeneers, C., Melén, E., Reier Nilsen, T., Rutjes, N. W., Ruotsalainen, M., Schaballie, H., Zwitserloot, A. M., Proesmans, M., and Mäkelä, M. J.
Published: 2024
Full Text: View/download PDF

2. ARIA 2016: Care pathways implementing emerging technologies for predictive medicine in rhinitis and asthma across the life cycle

Author: Bousquet, J., Hellings, P. W., Agache, I., Bedbrook, A., Bachert, C., Bergmann, K. C., Bewick, M., Bindslev-Jensen, C., Bosnic-Anticevitch, S., Bucca, C., Caimmi, D. P., Camargos, P. A. M., Canonica, G. W., Casale, T., Chavannes, N. H., Cruz, A. A., De Carlo, G., Dahl, R., Demoly, P., Devillier, P., Fonseca, J., Fokkens, W. J., Guldemond, N. A., Haahtela, T., Illario, M., Just, J., Keil, T., Klimek, L., Kuna, P., Larenas-Linnemann, D., Morais-Almeida, M., Mullol, J., Murray, R., Naclerio, R., O’Hehir, R. E., Papadopoulos, N. G., Pawankar, R., Potter, P., Ryan, D., Samolinski, B., Schunemann, H. J., Sheikh, A., Simons, F. E. R., Stellato, C., Todo-Bom, A., Tomazic, P. V., Valiulis, A., Valovirta, E., Ventura, M. T., Wickman, M., Young, I., Yorgancioglu, A., Zuberbier, T., Aberer, W., Akdis, C. A., Akdis, M., Annesi-Maesano, I., Ankri, J., Ansotegui, I. J., Anto, J. M., Arnavielhe, S., Asarnoj, A., Arshad, H., Avolio, F., Baiardini, I., Barbara, C., Barbagallo, M., Bateman, E. D., Beghé, B., Bel, E. H., Bennoor, K. S., Benson, M., Białoszewski, A. Z., Bieber, T., Bjermer, L., Blain, H., Blasi, F., Boner, A. L., Bonini, M., Bonini, S., Bosse, I., Bouchard, J., Boulet, L. P., Bourret, R., Bousquet, P. J., Braido, F., Briggs, A. H., Brightling, C. E., Brozek, J., Buhl, R., Bunu, C., Burte, E., Bush, A., Caballero-Fonseca, F., Calderon, M. A., Camuzat, T., Cardona, V., Carreiro-Martins, P., Carriazo, A. M., Carlsen, K. H., Carr, W., Cepeda Sarabia, A. M., Cesari, M., Chatzi, L., Chiron, R., Chivato, T., Chkhartishvili, E., Chuchalin, A. G., Chung, K. F., Ciprandi, G., de Sousa, J. Correia, Cox, L., Crooks, G., Custovic, A., Dahlen, S. E., Darsow, U., Dedeu, T., Deleanu, D., Denburg, J. A., De Vries, G., Didier, A., Dinh-Xuan, A. T., Dokic, D., Douagui, H., Dray, G., Dubakiene, R., Durham, S. R., Du Toit, G., Dykewicz, M. S., Eklund, P., El-Gamal, Y., Ellers, E., Emuzyte, R., Farrell, J., Fink Wagner, A., Fiocchi, A., Fletcher, M., Forastiere, F., Gaga, M., Gamkrelidze, A., Gemicioğlu, B., Gereda, J. E., van Wick, R. Gerth, González Diaz, S., Grisle, I., Grouse, L., Gutter, Z., Guzmán, M. A., Hellquist-Dahl, B., Heinrich, J., Horak, F., Hourihane, J. O’. B., Humbert, M., Hyland, M., Iaccarino, G., Jares, E. J., Jeandel, C., Johnston, S. L., Joos, G., Jonquet, O., Jung, K. S., Jutel, M., Kaidashev, I., Khaitov, M., Kalayci, O., Kalyoncu, A. F., Kardas, P., Keith, P. K., Kerkhof, M., Kerstjens, H. A. M., Khaltaev, N., Kogevinas, M., Kolek, V., Koppelman, G. H., Kowalski, M. L., Kuitunen, M., Kull, I., Kvedariene, V., Lambrecht, B., Lau, S., Laune, D., Le, L. T. T., Lieberman, P., Lipworth, B., Li, J., Lodrup Carlsen, K. C., Louis, R., Lupinek, C., MacNee, W., Magar, Y., Magnan, A., Mahboub, B., Maier, D., Majer, I., Malva, J., Manning, P., De Manuel Keenoy, E., Marshall, G. D., Masjedi, M. R., Mathieu-Dupas, E., Maurer, M., Mavale-Manuel, S., Melén, E., Melo-Gomes, E., Meltzer, E. O., Mercier, J., Merk, H., Miculinic, N., Mihaltan, F., Milenkovic, B., Millot-Keurinck, J., Mohammad, Y., Momas, I., Mösges, R., Muraro, A., Namazova-Baranova, L., Nadif, R., Neffen, H., Nekam, K., Nieto, A., Niggemann, B., Nogueira-Silva, L., Nogues, M., Nyembue, T. D., Ohta, K., Okamoto, Y., Okubo, K., Olive-Elias, M., Ouedraogo, S., Paggiaro, P., Pali-Schöll, I., Palkonen, S., Panzner, P., Papi, A., Park, H. S., Passalacqua, G., Pedersen, S., Pereira, A. M., Pfaar, O., Picard, R., Pigearias, B., Pin, I., Plavec, D., Pohl, W., Popov, T. A., Portejoie, F., Postma, D., Poulsen, L. K., Price, D., Rabe, K. F., Raciborski, F., Roberts, G., Robalo-Cordeiro, C., Rodenas, F., Rodriguez-Mañas, L., Rolland, C., Roman Rodriguez, M., Romano, A., Rosado-Pinto, J., Rosario, N., Rottem, M., Sanchez-Borges, M., Sastre-Dominguez, J., Scadding, G. K., Scichilone, N., Schmid-Grendelmeier, P., Serrano, E., Shields, M., Siroux, V., Sisul, J. C., Skrindo, I., Smit, H. A., Solé, D., Sooronbaev, T., Spranger, O., Stelmach, R., Sterk, P. J., Strandberg, T., Sunyer, J., Thijs, C., Triggiani, M., Valenta, R., Valero, A., van Eerd, M., van Ganse, E., van Hague, M., Vandenplas, O., Varona, L. L., Vellas, B., Vezzani, G., Vazankari, T., Viegi, G., Vontetsianos, T., Wagenmann, M., Walker, S., Wang, D. Y., Wahn, U., Werfel, T., Whalley, B., Williams, D. M., Williams, S., Wilson, N., Wright, J., Yawn, B. P., Yiallouros, P. K., Yusuf, O. M., Zaidi, A., Zar, H. J., Zernotti, M. E., Zhang, L., Zhong, N., and Zidarn, M.
Published: 2016
Full Text: View/download PDF

3. Erratum to : Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3: Area 5)

Author: Bousquet, J, Farrell, J, Crooks, G, Hellings, P, Bel, E H, Bewick, M, Chavannes, N H, de Sousa, J Correia, Cruz, A A, Haahtela, T, Joos, G, Khaltaev, N, Malva, J, Muraro, A, Nogues, M, Palkonen, S, Pedersen, S, Robalo-Cordeiro, C, Samolinski, B, Strandberg, T, Valiulis, A, Yorgancioglu, A, Zuberbier, T, Bedbrook, A, Aberer, W, Adachi, M, Agusti, A, Akdis, C A, Akdis, M, Ankri, J, Alonso, A, Annesi-Maesano, I, Ansotegui, I J, Anto, J M, Arnavielhe, S, Arshad, H, Bai, C, Baiardini, I, Bachert, C, Baigenzhin, A K, Barbara, C, Bateman, E D, Beghé, B, Kheder, A Ben, Bennoor, K S, Benson, M, Bergmann, K C, Bieber, T, Bindslev-Jensen, C, Bjermer, L, Blain, H, Blasi, F, Boner, A L, Bonini, M, Bonini, S, Bosnic-Anticevitch, S, Boulet, L P, Bourret, R, Bousquet, P J, Braido, F, Briggs, A H, Brightling, C E, Brozek, J, Buhl, R, Burney, P G, Bush, A, Caballero-Fonseca, F, Caimmi, D, Calderon, M A, Calverley, P M, Camargos, P A M, Canonica, G W, Camuzat, T, Carlsen, K H, Carr, W, Carriazo, A, Casale, T, Cepeda Sarabia, A M, Chatzi, L, Chen, Y Z, Chiron, R, Chkhartishvili, E, Chuchalin, A G, Chung, K F, Ciprandi, G, Cirule, I, Cox, L, Costa, D J, Custovic, A, Dahl, R, Dahlen, S E, Darsow, U, De Carlo, G, De Blay, F, Dedeu, T, Deleanu, D, De Manuel Keenoy, E, Demoly, P, Denburg, J A, Devillier, P, Didier, A, Dinh-Xuan, A T, Djukanovic, R, Dokic, D, Douagui, H, Dray, G, Dubakiene, R, Durham, S R, Dykewicz, M S, El-Gamal, Y, Emuzyte, R, Fabbri, L M, Fletcher, M, Fiocchi, A, Fink Wagner, A, Fonseca, J, Fokkens, W J, Forastiere, F, Frith, P, Gaga, M, Gamkrelidze, A, Garces, J, Garcia-Aymerich, J, Gemicioğlu, B, Gereda, J E, González Diaz, S, Gotua, M, Grisle, I, Grouse, L, Gutter, Z, Guzmán, M A, Heaney, L G, Hellquist-Dahl, B, Henderson, D, Hendry, A, Heinrich, J, Heve, D, Horak, F, Hourihane, J O' B, Howarth, P, Humbert, M, Hyland, M E, Illario, M, Ivancevich, J C, Jardim, J R, Jares, E J, Jeandel, C, Jenkins, C, Johnston, S L, Jonquet, O, Julge, K, Jung, K S, Just, J, Kaidashev, I, Khaitov, M R, Kalayci, O, Kalyoncu, A F, Keil, T, Keith, P K, Klimek, L, Koffi N'Goran, B, Kolek, V, Koppelman, G H, Kowalski, M L, Kull, I, Kuna, P, Kvedariene, V, Lambrecht, B, Lau, S, Larenas-Linnemann, D, Laune, D, Le, L T T, Lieberman, P, Lipworth, B, Li, J, Lodrup Carlsen, K, Louis, R, MacNee, W, Magard, Y, Magnan, A, Mahboub, B, Mair, A, Majer, I, Makela, M J, Manning, P, Mara, S, Marshall, G D, Masjedi, M R, Matignon, P, Maurer, M, Mavale-Manuel, S, Melén, E, Melo-Gomes, E, Meltzer, E O, Menzies-Gow, A, Merk, H, Michel, J P, Miculinic, N, Mihaltan, F, Milenkovic, B, Mohammad, G M Y, Molimard, M, Momas, I, Montilla-Santana, A, Morais-Almeida, M, Morgan, M, Mösges, R, Mullol, J, Nafti, S, Namazova-Baranova, L, Naclerio, R, Neou, A, Neffen, H, Nekam, K, Niggemann, B, Ninot, G, Nyembue, T D, O'Hehir, R E, Ohta, K, Okamoto, Y, Okubo, K, Ouedraogo, S, Paggiaro, P, Pali-Schöll, I, Panzner, P, Papadopoulos, N, Papi, A, Park, H S, Passalacqua, G, Pavord, I, Pawankar, R, Pengelly, R, Pfaar, O, Picard, R, Pigearias, B, Pin, I, Plavec, D, Poethig, D, Pohl, W, Popov, T A, Portejoie, F, Potter, P, Postma, D, Price, D, Rabe, K F, Raciborski, F, Radier Pontal, F, Repka-Ramirez, S, Reitamo, S, Rennard, S, Rodenas, F, Roberts, J, Roca, J, Rodriguez Mañas, L, Rolland, C, Roman Rodriguez, M, Romano, A, Rosado-Pinto, J, Rosario, N, Rosenwasser, L, Rottem, M, Ryan, D, Sanchez-Borges, M, Scadding, G K, Schunemann, H J, Serrano, E, Schmid-Grendelmeier, P, Schulz, H, Sheikh, A, Shields, M, Siafakas, N, Sibille, Y, Similowski, T, Simons, F E R, Sisul, J C, Skrindo, I, Smit, H A, Solé, D, Sooronbaev, T, Spranger, O, Stelmach, R, Sterk, P J, Sunyer, J, Thijs, C, To, T, Todo-Bom, A, Triggiani, M, Valenta, R, Valero, A L, Valia, E, Valovirta, E, Van Ganse, E, van Hage, M, Vandenplas, O, Vasankari, T, Vellas, B, Vestbo, J, Vezzani, G, Vichyanond, P, Viegi, G, Vogelmeier, C, Vontetsianos, T, Wagenmann, M, Wallaert, B, Walker, S, Wang, D Y, Wahn, U, Wickman, M, Williams, D M, Williams, S, Wright, J, Yawn, B P, Yiallouros, P K, Yusuf, O M, Zaidi, A, Zar, H J, Zernotti, M E, Zhang, L, Zhong, N, Zidarn, M, Mercier, J, Bousquet, J, Farrell, J, Crooks, G, Hellings, P, Bel, E H, Bewick, M, Chavannes, N H, de Sousa, J Correia, Cruz, A A, Haahtela, T, Joos, G, Khaltaev, N, Malva, J, Muraro, A, Nogues, M, Palkonen, S, Pedersen, S, Robalo-Cordeiro, C, Samolinski, B, Strandberg, T, Valiulis, A, Yorgancioglu, A, Zuberbier, T, Bedbrook, A, Aberer, W, Adachi, M, Agusti, A, Akdis, C A, Akdis, M, Ankri, J, Alonso, A, Annesi-Maesano, I, Ansotegui, I J, Anto, J M, Arnavielhe, S, Arshad, H, Bai, C, Baiardini, I, Bachert, C, Baigenzhin, A K, Barbara, C, Bateman, E D, Beghé, B, Kheder, A Ben, Bennoor, K S, Benson, M, Bergmann, K C, Bieber, T, Bindslev-Jensen, C, Bjermer, L, Blain, H, Blasi, F, Boner, A L, Bonini, M, Bonini, S, Bosnic-Anticevitch, S, Boulet, L P, Bourret, R, Bousquet, P J, Braido, F, Briggs, A H, Brightling, C E, Brozek, J, Buhl, R, Burney, P G, Bush, A, Caballero-Fonseca, F, Caimmi, D, Calderon, M A, Calverley, P M, Camargos, P A M, Canonica, G W, Camuzat, T, Carlsen, K H, Carr, W, Carriazo, A, Casale, T, Cepeda Sarabia, A M, Chatzi, L, Chen, Y Z, Chiron, R, Chkhartishvili, E, Chuchalin, A G, Chung, K F, Ciprandi, G, Cirule, I, Cox, L, Costa, D J, Custovic, A, Dahl, R, Dahlen, S E, Darsow, U, De Carlo, G, De Blay, F, Dedeu, T, Deleanu, D, De Manuel Keenoy, E, Demoly, P, Denburg, J A, Devillier, P, Didier, A, Dinh-Xuan, A T, Djukanovic, R, Dokic, D, Douagui, H, Dray, G, Dubakiene, R, Durham, S R, Dykewicz, M S, El-Gamal, Y, Emuzyte, R, Fabbri, L M, Fletcher, M, Fiocchi, A, Fink Wagner, A, Fonseca, J, Fokkens, W J, Forastiere, F, Frith, P, Gaga, M, Gamkrelidze, A, Garces, J, Garcia-Aymerich, J, Gemicioğlu, B, Gereda, J E, González Diaz, S, Gotua, M, Grisle, I, Grouse, L, Gutter, Z, Guzmán, M A, Heaney, L G, Hellquist-Dahl, B, Henderson, D, Hendry, A, Heinrich, J, Heve, D, Horak, F, Hourihane, J O' B, Howarth, P, Humbert, M, Hyland, M E, Illario, M, Ivancevich, J C, Jardim, J R, Jares, E J, Jeandel, C, Jenkins, C, Johnston, S L, Jonquet, O, Julge, K, Jung, K S, Just, J, Kaidashev, I, Khaitov, M R, Kalayci, O, Kalyoncu, A F, Keil, T, Keith, P K, Klimek, L, Koffi N'Goran, B, Kolek, V, Koppelman, G H, Kowalski, M L, Kull, I, Kuna, P, Kvedariene, V, Lambrecht, B, Lau, S, Larenas-Linnemann, D, Laune, D, Le, L T T, Lieberman, P, Lipworth, B, Li, J, Lodrup Carlsen, K, Louis, R, MacNee, W, Magard, Y, Magnan, A, Mahboub, B, Mair, A, Majer, I, Makela, M J, Manning, P, Mara, S, Marshall, G D, Masjedi, M R, Matignon, P, Maurer, M, Mavale-Manuel, S, Melén, E, Melo-Gomes, E, Meltzer, E O, Menzies-Gow, A, Merk, H, Michel, J P, Miculinic, N, Mihaltan, F, Milenkovic, B, Mohammad, G M Y, Molimard, M, Momas, I, Montilla-Santana, A, Morais-Almeida, M, Morgan, M, Mösges, R, Mullol, J, Nafti, S, Namazova-Baranova, L, Naclerio, R, Neou, A, Neffen, H, Nekam, K, Niggemann, B, Ninot, G, Nyembue, T D, O'Hehir, R E, Ohta, K, Okamoto, Y, Okubo, K, Ouedraogo, S, Paggiaro, P, Pali-Schöll, I, Panzner, P, Papadopoulos, N, Papi, A, Park, H S, Passalacqua, G, Pavord, I, Pawankar, R, Pengelly, R, Pfaar, O, Picard, R, Pigearias, B, Pin, I, Plavec, D, Poethig, D, Pohl, W, Popov, T A, Portejoie, F, Potter, P, Postma, D, Price, D, Rabe, K F, Raciborski, F, Radier Pontal, F, Repka-Ramirez, S, Reitamo, S, Rennard, S, Rodenas, F, Roberts, J, Roca, J, Rodriguez Mañas, L, Rolland, C, Roman Rodriguez, M, Romano, A, Rosado-Pinto, J, Rosario, N, Rosenwasser, L, Rottem, M, Ryan, D, Sanchez-Borges, M, Scadding, G K, Schunemann, H J, Serrano, E, Schmid-Grendelmeier, P, Schulz, H, Sheikh, A, Shields, M, Siafakas, N, Sibille, Y, Similowski, T, Simons, F E R, Sisul, J C, Skrindo, I, Smit, H A, Solé, D, Sooronbaev, T, Spranger, O, Stelmach, R, Sterk, P J, Sunyer, J, Thijs, C, To, T, Todo-Bom, A, Triggiani, M, Valenta, R, Valero, A L, Valia, E, Valovirta, E, Van Ganse, E, van Hage, M, Vandenplas, O, Vasankari, T, Vellas, B, Vestbo, J, Vezzani, G, Vichyanond, P, Viegi, G, Vogelmeier, C, Vontetsianos, T, Wagenmann, M, Wallaert, B, Walker, S, Wang, D Y, Wahn, U, Wickman, M, Williams, D M, Williams, S, Wright, J, Yawn, B P, Yiallouros, P K, Yusuf, O M, Zaidi, A, Zar, H J, Zernotti, M E, Zhang, L, Zhong, N, Zidarn, M, and Mercier, J
Published: 2017

4. Erratum to: Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3: Area 5).

Author: UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (MGD) Service de pneumologie, Bousquet, J, Farrell, J, Crooks, G, Hellings, P, Bel, E H, Bewick, M, Chavannes, N H, de Sousa, J Correia, Cruz, A A, Haahtela, T, Joos, G, Khaltaev, N, Malva, J, Muraro, A, Nogues, M, Palkonen, S, Pedersen, S, Robalo-Cordeiro, C, Samolinski, B, Strandberg, T, Valiulis, A, Yorgancioglu, A, Zuberbier, T, Bedbrook, A, Aberer, W, Adachi, M, Agusti, A, Akdis, C A, Akdis, M, Ankri, J, Alonso, A, Annesi-Maesano, I, Ansotegui, I J, Anto, J M, Arnavielhe, S, Arshad, H, Bai, C, Baiardini, I, Bachert, C, Baigenzhin, A K, Barbara, C, Bateman, E D, Beghé, B, Kheder, A Ben, Bennoor, K S, Benson, M, Bergmann, K C, Bieber, T, Bindslev-Jensen, C, Bjermer, L, Blain, H, Blasi, F, Boner, A L, Bonini, M, Bonini, S, Bosnic-Anticevitch, S, Boulet, L P, Bourret, R, Bousquet, P J, Braido, F, Briggs, A H, Brightling, C E, Brozek, J, Buhl, R, Burney, P G, Bush, A, Caballero-Fonseca, F, Caimmi, D, Calderon, M A, Calverley, P M, Camargos, P A M, Canonica, G W, Camuzat, T, Carlsen, K H, Carr, W, Carriazo, A, Casale, T, Cepeda Sarabia, A M, Chatzi, L, Chen, Y Z, Chiron, R, Chkhartishvili, E, Chuchalin, A G, Chung, K F, Ciprandi, G, Cirule, I, Cox, L, Costa, D J, Custovic, A, Dahl, R, Dahlen, S E, Darsow, U, De Carlo, G, De Blay, F, Dedeu, T, Deleanu, D, De Manuel Keenoy, E, Demoly, P, Denburg, J A, Devillier, P, Didier, A, Dinh-Xuan, A T, Djukanovic, R, Dokic, D, Douagui, H, Dray, G, Dubakiene, R, Durham, S R, Dykewicz, M S, El-Gamal, Y, Emuzyte, R, Fabbri, L M, Fletcher, M, Fiocchi, A, Fink Wagner, A, Fonseca, J, Fokkens, W J, Forastiere, F, Frith, P, Gaga, M, Gamkrelidze, A, Garces, J, Garcia-Aymerich, J, Gemicioğlu, B, Gereda, J E, González Diaz, S, Gotua, M, Grisle, I, Grouse, L, Gutter, Z, Guzmán, M A, Heaney, L G, Hellquist-Dahl, B, Henderson, D, Hendry, A, Heinrich, J, Heve, D, Horak, F, Hourihane, J O' B, Howarth, P, Humbert, M, Hyland, M E, Illario, M, Ivancevich, J C, Jardim, J R, Jares, E J, Jeandel, C, Jenkins, C, Johnston, S L, Jonquet, O, Julge, K, Jung, K S, Just, J, Kaidashev, I, Khaitov, M R, Kalayci, O, Kalyoncu, A F, Keil, T, Keith, P K, Klimek, L, Koffi N'Goran, B, Kolek, V, Koppelman, G H, Kowalski, M L, Kull, I, Kuna, P, Kvedariene, V, Lambrecht, B, Lau, S, Larenas-Linnemann, D, Laune, D, Le, L T T, Lieberman, P, Lipworth, B, Li, J, Lodrup Carlsen, K, Louis, R, MacNee, W, Magard, Y, Magnan, A, Mahboub, B, Mair, A, Majer, I, Makela, M J, Manning, P, Mara, S, Marshall, G D, Masjedi, M R, Matignon, P, Maurer, M, Mavale-Manuel, S, Melén, E, Melo-Gomes, E, Meltzer, E O, Menzies-Gow, A, Merk, H, Michel, J P, Miculinic, N, Mihaltan, F, Milenkovic, B, Mohammad, G M Y, Molimard, M, Momas, I, Montilla-Santana, A, Morais-Almeida, M, Morgan, M, Mösges, R, Mullol, J, Nafti, S, Namazova-Baranova, L, Naclerio, R, Neou, A, Neffen, H, Nekam, K, Niggemann, B, Ninot, G, Nyembue, T D, O'Hehir, R E, Ohta, K, Okamoto, Y, Okubo, K, Ouedraogo, S, Paggiaro, P, Pali-Schöll, I, Panzner, P, Papadopoulos, N, Papi, A, Park, H S, Passalacqua, G, Pavord, I, Pawankar, R, Pengelly, R, Pfaar, O, Picard, R, Pigearias, B, Pin, I, Plavec, D, Poethig, D, Pohl, W, Popov, T A, Portejoie, F, Potter, P, Postma, D, Price, D, Rabe, K F, Raciborski, F, Radier Pontal, F, Repka-Ramirez, S, Reitamo, S, Rennard, S, Rodenas, F, Roberts, J, Roca, J, Rodriguez Mañas, L, Rolland, C, Roman Rodriguez, M, Romano, A, Rosado-Pinto, J, Rosario, N, Rosenwasser, L, Rottem, M, Ryan, D, Sanchez-Borges, M, Scadding, G K, Schunemann, H J, Serrano, E, Schmid-Grendelmeier, P, Schulz, H, Sheikh, A, Shields, M, Siafakas, N, Sibille, Yves, Similowski, T, Simons, F E R, Sisul, J C, Skrindo, I, Smit, H A, Solé, D, Sooronbaev, T, Spranger, O, Stelmach, R, Sterk, P J, Sunyer, J, Thijs, C, To, T, Todo-Bom, A, Triggiani, M, Valenta, R, Valero, A L, Valia, E, Valovirta, E, Van Ganse, E, van Hage, M, Vandenplas, Olivier, Vasankari, T, Vellas, B, Vestbo, J, Vezzani, G, Vichyanond, P, Viegi, G, Vogelmeier, C, Vontetsianos, T, Wagenmann, M, Wallaert, B, Walker, S, Wang, D Y, Wahn, U, Wickman, M, Williams, D M, Williams, S, Wright, J, Yawn, B P, Yiallouros, P K, Yusuf, O M, Zaidi, A, Zar, H J, Zernotti, M E, Zhang, L, Zhong, N, Zidarn, M, Mercier, J, UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (MGD) Service de pneumologie, Bousquet, J, Farrell, J, Crooks, G, Hellings, P, Bel, E H, Bewick, M, Chavannes, N H, de Sousa, J Correia, Cruz, A A, Haahtela, T, Joos, G, Khaltaev, N, Malva, J, Muraro, A, Nogues, M, Palkonen, S, Pedersen, S, Robalo-Cordeiro, C, Samolinski, B, Strandberg, T, Valiulis, A, Yorgancioglu, A, Zuberbier, T, Bedbrook, A, Aberer, W, Adachi, M, Agusti, A, Akdis, C A, Akdis, M, Ankri, J, Alonso, A, Annesi-Maesano, I, Ansotegui, I J, Anto, J M, Arnavielhe, S, Arshad, H, Bai, C, Baiardini, I, Bachert, C, Baigenzhin, A K, Barbara, C, Bateman, E D, Beghé, B, Kheder, A Ben, Bennoor, K S, Benson, M, Bergmann, K C, Bieber, T, Bindslev-Jensen, C, Bjermer, L, Blain, H, Blasi, F, Boner, A L, Bonini, M, Bonini, S, Bosnic-Anticevitch, S, Boulet, L P, Bourret, R, Bousquet, P J, Braido, F, Briggs, A H, Brightling, C E, Brozek, J, Buhl, R, Burney, P G, Bush, A, Caballero-Fonseca, F, Caimmi, D, Calderon, M A, Calverley, P M, Camargos, P A M, Canonica, G W, Camuzat, T, Carlsen, K H, Carr, W, Carriazo, A, Casale, T, Cepeda Sarabia, A M, Chatzi, L, Chen, Y Z, Chiron, R, Chkhartishvili, E, Chuchalin, A G, Chung, K F, Ciprandi, G, Cirule, I, Cox, L, Costa, D J, Custovic, A, Dahl, R, Dahlen, S E, Darsow, U, De Carlo, G, De Blay, F, Dedeu, T, Deleanu, D, De Manuel Keenoy, E, Demoly, P, Denburg, J A, Devillier, P, Didier, A, Dinh-Xuan, A T, Djukanovic, R, Dokic, D, Douagui, H, Dray, G, Dubakiene, R, Durham, S R, Dykewicz, M S, El-Gamal, Y, Emuzyte, R, Fabbri, L M, Fletcher, M, Fiocchi, A, Fink Wagner, A, Fonseca, J, Fokkens, W J, Forastiere, F, Frith, P, Gaga, M, Gamkrelidze, A, Garces, J, Garcia-Aymerich, J, Gemicioğlu, B, Gereda, J E, González Diaz, S, Gotua, M, Grisle, I, Grouse, L, Gutter, Z, Guzmán, M A, Heaney, L G, Hellquist-Dahl, B, Henderson, D, Hendry, A, Heinrich, J, Heve, D, Horak, F, Hourihane, J O' B, Howarth, P, Humbert, M, Hyland, M E, Illario, M, Ivancevich, J C, Jardim, J R, Jares, E J, Jeandel, C, Jenkins, C, Johnston, S L, Jonquet, O, Julge, K, Jung, K S, Just, J, Kaidashev, I, Khaitov, M R, Kalayci, O, Kalyoncu, A F, Keil, T, Keith, P K, Klimek, L, Koffi N'Goran, B, Kolek, V, Koppelman, G H, Kowalski, M L, Kull, I, Kuna, P, Kvedariene, V, Lambrecht, B, Lau, S, Larenas-Linnemann, D, Laune, D, Le, L T T, Lieberman, P, Lipworth, B, Li, J, Lodrup Carlsen, K, Louis, R, MacNee, W, Magard, Y, Magnan, A, Mahboub, B, Mair, A, Majer, I, Makela, M J, Manning, P, Mara, S, Marshall, G D, Masjedi, M R, Matignon, P, Maurer, M, Mavale-Manuel, S, Melén, E, Melo-Gomes, E, Meltzer, E O, Menzies-Gow, A, Merk, H, Michel, J P, Miculinic, N, Mihaltan, F, Milenkovic, B, Mohammad, G M Y, Molimard, M, Momas, I, Montilla-Santana, A, Morais-Almeida, M, Morgan, M, Mösges, R, Mullol, J, Nafti, S, Namazova-Baranova, L, Naclerio, R, Neou, A, Neffen, H, Nekam, K, Niggemann, B, Ninot, G, Nyembue, T D, O'Hehir, R E, Ohta, K, Okamoto, Y, Okubo, K, Ouedraogo, S, Paggiaro, P, Pali-Schöll, I, Panzner, P, Papadopoulos, N, Papi, A, Park, H S, Passalacqua, G, Pavord, I, Pawankar, R, Pengelly, R, Pfaar, O, Picard, R, Pigearias, B, Pin, I, Plavec, D, Poethig, D, Pohl, W, Popov, T A, Portejoie, F, Potter, P, Postma, D, Price, D, Rabe, K F, Raciborski, F, Radier Pontal, F, Repka-Ramirez, S, Reitamo, S, Rennard, S, Rodenas, F, Roberts, J, Roca, J, Rodriguez Mañas, L, Rolland, C, Roman Rodriguez, M, Romano, A, Rosado-Pinto, J, Rosario, N, Rosenwasser, L, Rottem, M, Ryan, D, Sanchez-Borges, M, Scadding, G K, Schunemann, H J, Serrano, E, Schmid-Grendelmeier, P, Schulz, H, Sheikh, A, Shields, M, Siafakas, N, Sibille, Yves, Similowski, T, Simons, F E R, Sisul, J C, Skrindo, I, Smit, H A, Solé, D, Sooronbaev, T, Spranger, O, Stelmach, R, Sterk, P J, Sunyer, J, Thijs, C, To, T, Todo-Bom, A, Triggiani, M, Valenta, R, Valero, A L, Valia, E, Valovirta, E, Van Ganse, E, van Hage, M, Vandenplas, Olivier, Vasankari, T, Vellas, B, Vestbo, J, Vezzani, G, Vichyanond, P, Viegi, G, Vogelmeier, C, Vontetsianos, T, Wagenmann, M, Wallaert, B, Walker, S, Wang, D Y, Wahn, U, Wickman, M, Williams, D M, Williams, S, Wright, J, Yawn, B P, Yiallouros, P K, Yusuf, O M, Zaidi, A, Zar, H J, Zernotti, M E, Zhang, L, Zhong, N, Zidarn, M, and Mercier, J
Abstract: [This corrects the article DOI: 10.1186/s13601-016-0116-9.].
Published: 2017

5. Erratum to: Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3: Area 5)

Author: Unit Opleiding Aios, Other research (not in main researchprogram), Circulatory Health, Child Health, JC onderzoeksprogramma Infectieziekten, Public Health Epidemiologie, Bousquet, J, Farrell, J, Crooks, G, Hellings, P, Bel, E H, Bewick, M, Chavannes, N H, de Sousa, J Correia, Cruz, A A, Haahtela, T, Joos, G, Khaltaev, N, Malva, J, Muraro, A, Nogues, M, Palkonen, S, Pedersen, S, Robalo-Cordeiro, C, Samolinski, B, Strandberg, T, Valiulis, A, Yorgancioglu, A, Zuberbier, T, Bedbrook, A, Aberer, W, Adachi, M, Agusti, A, Akdis, C A, Akdis, M, Ankri, J, Alonso, A, Annesi-Maesano, I, Ansotegui, I J, Anto, J M, Arnavielhe, S, Arshad, H, Bai, C, Baiardini, I, Bachert, C, Baigenzhin, A K, Barbara, C, Bateman, E D, Beghé, B, Kheder, A Ben, Bennoor, K S, Benson, M, Bergmann, K C, Bieber, T, Bindslev-Jensen, C, Bjermer, L, Blain, H, Blasi, F, Boner, A L, Bonini, M, Bonini, S, Bosnic-Anticevitch, S, Boulet, L P, Bourret, R, Bousquet, P J, Braido, F, Briggs, A H, Brightling, C E, Brozek, J, Buhl, R, Burney, P G, Bush, A, Caballero-Fonseca, F, Caimmi, D, Calderon, M A, Calverley, P M, Camargos, P A M, Canonica, G W, Camuzat, T, Carlsen, K H, Carr, W, Carriazo, A, Casale, T, Cepeda Sarabia, A M, Chatzi, L, Chen, Y Z, Chiron, R, Chkhartishvili, E, Chuchalin, A G, Chung, K F, Ciprandi, G, Cirule, I, Cox, L, Costa, D J, Custovic, A, Dahl, R, Dahlen, S E, Darsow, U, De Carlo, G, De Blay, F, Dedeu, T, Deleanu, D, De Manuel Keenoy, E, Demoly, P, Denburg, J A, Devillier, P, Didier, A, Dinh-Xuan, A T, Djukanovic, R, Dokic, D, Douagui, H, Dray, G, Dubakiene, R, Durham, S R, Dykewicz, M S, El-Gamal, Y, Emuzyte, R, Fabbri, L M, Fletcher, M, Fiocchi, A, Fink Wagner, A, Fonseca, J, Fokkens, W J, Forastiere, F, Frith, P, Gaga, M, Gamkrelidze, A, Garces, J, Garcia-Aymerich, J, Gemicioğlu, B, Gereda, J E, González Diaz, S, Gotua, M, Grisle, I, Grouse, L, Gutter, Z, Guzmán, M A, Heaney, L G, Hellquist-Dahl, B, Henderson, D, Hendry, A, Heinrich, J, Heve, D, Horak, F, Hourihane, J O' B, Howarth, P, Humbert, M, Hyland, M E, Illario, M, Ivancevich, J C, Jardim, J R, Jares, E J, Jeandel, C, Jenkins, C, Johnston, S L, Jonquet, O, Julge, K, Jung, K S, Just, J, Kaidashev, I, Khaitov, M R, Kalayci, O, Kalyoncu, A F, Keil, T, Keith, P K, Klimek, L, Koffi N'Goran, B, Kolek, V, Koppelman, G H, Kowalski, M L, Kull, I, Kuna, P, Kvedariene, V, Lambrecht, B, Lau, S, Larenas-Linnemann, D, Laune, D, Le, L T T, Lieberman, P, Lipworth, B, Li, J, Lodrup Carlsen, K, Louis, R, MacNee, W, Magard, Y, Magnan, A, Mahboub, B, Mair, A, Majer, I, Makela, M J, Manning, P, Mara, S, Marshall, G D, Masjedi, M R, Matignon, P, Maurer, M, Mavale-Manuel, S, Melén, E, Melo-Gomes, E, Meltzer, E O, Menzies-Gow, A, Merk, H, Michel, J P, Miculinic, N, Mihaltan, F, Milenkovic, B, Mohammad, G M Y, Molimard, M, Momas, I, Montilla-Santana, A, Morais-Almeida, M, Morgan, M, Mösges, R, Mullol, J, Nafti, S, Namazova-Baranova, L, Naclerio, R, Neou, A, Neffen, H, Nekam, K, Niggemann, B, Ninot, G, Nyembue, T D, O'Hehir, R E, Ohta, K, Okamoto, Y, Okubo, K, Ouedraogo, S, Paggiaro, P, Pali-Schöll, I, Panzner, P, Papadopoulos, N, Papi, A, Park, H S, Passalacqua, G, Pavord, I, Pawankar, R, Pengelly, R, Pfaar, O, Picard, R, Pigearias, B, Pin, I, Plavec, D, Poethig, D, Pohl, W, Popov, T A, Portejoie, F, Potter, P, Postma, D, Price, D, Rabe, K F, Raciborski, F, Radier Pontal, F, Repka-Ramirez, S, Reitamo, S, Rennard, S, Rodenas, F, Roberts, J, Roca, J, Rodriguez Mañas, L, Rolland, C, Roman Rodriguez, M, Romano, A, Rosado-Pinto, J, Rosario, N, Rosenwasser, L, Rottem, M, Ryan, D, Sanchez-Borges, M, Scadding, G K, Schunemann, H J, Serrano, E, Schmid-Grendelmeier, P, Schulz, H, Sheikh, A, Shields, M, Siafakas, N, Sibille, Y, Similowski, T, Simons, F E R, Sisul, J C, Skrindo, I, Smit, H A, Solé, D, Sooronbaev, T, Spranger, O, Stelmach, R, Sterk, P J, Sunyer, J, Thijs, C, To, T, Todo-Bom, A, Triggiani, M, Valenta, R, Valero, A L, Valia, E, Valovirta, E, Van Ganse, E, van Hage, M, Vandenplas, O, Vasankari, T, Vellas, B, Vestbo, J, Vezzani, G, Vichyanond, P, Viegi, G, Vogelmeier, C, Vontetsianos, T, Wagenmann, M, Wallaert, B, Walker, S, Wang, D Y, Wahn, U, Wickman, M, Williams, D M, Williams, S, Wright, J, Yawn, B P, Yiallouros, P K, Yusuf, O M, Zaidi, A, Zar, H J, Zernotti, M E, Zhang, L, Zhong, N, Zidarn, M, Mercier, J, Unit Opleiding Aios, Other research (not in main researchprogram), Circulatory Health, Child Health, JC onderzoeksprogramma Infectieziekten, Public Health Epidemiologie, Bousquet, J, Farrell, J, Crooks, G, Hellings, P, Bel, E H, Bewick, M, Chavannes, N H, de Sousa, J Correia, Cruz, A A, Haahtela, T, Joos, G, Khaltaev, N, Malva, J, Muraro, A, Nogues, M, Palkonen, S, Pedersen, S, Robalo-Cordeiro, C, Samolinski, B, Strandberg, T, Valiulis, A, Yorgancioglu, A, Zuberbier, T, Bedbrook, A, Aberer, W, Adachi, M, Agusti, A, Akdis, C A, Akdis, M, Ankri, J, Alonso, A, Annesi-Maesano, I, Ansotegui, I J, Anto, J M, Arnavielhe, S, Arshad, H, Bai, C, Baiardini, I, Bachert, C, Baigenzhin, A K, Barbara, C, Bateman, E D, Beghé, B, Kheder, A Ben, Bennoor, K S, Benson, M, Bergmann, K C, Bieber, T, Bindslev-Jensen, C, Bjermer, L, Blain, H, Blasi, F, Boner, A L, Bonini, M, Bonini, S, Bosnic-Anticevitch, S, Boulet, L P, Bourret, R, Bousquet, P J, Braido, F, Briggs, A H, Brightling, C E, Brozek, J, Buhl, R, Burney, P G, Bush, A, Caballero-Fonseca, F, Caimmi, D, Calderon, M A, Calverley, P M, Camargos, P A M, Canonica, G W, Camuzat, T, Carlsen, K H, Carr, W, Carriazo, A, Casale, T, Cepeda Sarabia, A M, Chatzi, L, Chen, Y Z, Chiron, R, Chkhartishvili, E, Chuchalin, A G, Chung, K F, Ciprandi, G, Cirule, I, Cox, L, Costa, D J, Custovic, A, Dahl, R, Dahlen, S E, Darsow, U, De Carlo, G, De Blay, F, Dedeu, T, Deleanu, D, De Manuel Keenoy, E, Demoly, P, Denburg, J A, Devillier, P, Didier, A, Dinh-Xuan, A T, Djukanovic, R, Dokic, D, Douagui, H, Dray, G, Dubakiene, R, Durham, S R, Dykewicz, M S, El-Gamal, Y, Emuzyte, R, Fabbri, L M, Fletcher, M, Fiocchi, A, Fink Wagner, A, Fonseca, J, Fokkens, W J, Forastiere, F, Frith, P, Gaga, M, Gamkrelidze, A, Garces, J, Garcia-Aymerich, J, Gemicioğlu, B, Gereda, J E, González Diaz, S, Gotua, M, Grisle, I, Grouse, L, Gutter, Z, Guzmán, M A, Heaney, L G, Hellquist-Dahl, B, Henderson, D, Hendry, A, Heinrich, J, Heve, D, Horak, F, Hourihane, J O' B, Howarth, P, Humbert, M, Hyland, M E, Illario, M, Ivancevich, J C, Jardim, J R, Jares, E J, Jeandel, C, Jenkins, C, Johnston, S L, Jonquet, O, Julge, K, Jung, K S, Just, J, Kaidashev, I, Khaitov, M R, Kalayci, O, Kalyoncu, A F, Keil, T, Keith, P K, Klimek, L, Koffi N'Goran, B, Kolek, V, Koppelman, G H, Kowalski, M L, Kull, I, Kuna, P, Kvedariene, V, Lambrecht, B, Lau, S, Larenas-Linnemann, D, Laune, D, Le, L T T, Lieberman, P, Lipworth, B, Li, J, Lodrup Carlsen, K, Louis, R, MacNee, W, Magard, Y, Magnan, A, Mahboub, B, Mair, A, Majer, I, Makela, M J, Manning, P, Mara, S, Marshall, G D, Masjedi, M R, Matignon, P, Maurer, M, Mavale-Manuel, S, Melén, E, Melo-Gomes, E, Meltzer, E O, Menzies-Gow, A, Merk, H, Michel, J P, Miculinic, N, Mihaltan, F, Milenkovic, B, Mohammad, G M Y, Molimard, M, Momas, I, Montilla-Santana, A, Morais-Almeida, M, Morgan, M, Mösges, R, Mullol, J, Nafti, S, Namazova-Baranova, L, Naclerio, R, Neou, A, Neffen, H, Nekam, K, Niggemann, B, Ninot, G, Nyembue, T D, O'Hehir, R E, Ohta, K, Okamoto, Y, Okubo, K, Ouedraogo, S, Paggiaro, P, Pali-Schöll, I, Panzner, P, Papadopoulos, N, Papi, A, Park, H S, Passalacqua, G, Pavord, I, Pawankar, R, Pengelly, R, Pfaar, O, Picard, R, Pigearias, B, Pin, I, Plavec, D, Poethig, D, Pohl, W, Popov, T A, Portejoie, F, Potter, P, Postma, D, Price, D, Rabe, K F, Raciborski, F, Radier Pontal, F, Repka-Ramirez, S, Reitamo, S, Rennard, S, Rodenas, F, Roberts, J, Roca, J, Rodriguez Mañas, L, Rolland, C, Roman Rodriguez, M, Romano, A, Rosado-Pinto, J, Rosario, N, Rosenwasser, L, Rottem, M, Ryan, D, Sanchez-Borges, M, Scadding, G K, Schunemann, H J, Serrano, E, Schmid-Grendelmeier, P, Schulz, H, Sheikh, A, Shields, M, Siafakas, N, Sibille, Y, Similowski, T, Simons, F E R, Sisul, J C, Skrindo, I, Smit, H A, Solé, D, Sooronbaev, T, Spranger, O, Stelmach, R, Sterk, P J, Sunyer, J, Thijs, C, To, T, Todo-Bom, A, Triggiani, M, Valenta, R, Valero, A L, Valia, E, Valovirta, E, Van Ganse, E, van Hage, M, Vandenplas, O, Vasankari, T, Vellas, B, Vestbo, J, Vezzani, G, Vichyanond, P, Viegi, G, Vogelmeier, C, Vontetsianos, T, Wagenmann, M, Wallaert, B, Walker, S, Wang, D Y, Wahn, U, Wickman, M, Williams, D M, Williams, S, Wright, J, Yawn, B P, Yiallouros, P K, Yusuf, O M, Zaidi, A, Zar, H J, Zernotti, M E, Zhang, L, Zhong, N, Zidarn, M, and Mercier, J
Published: 2017

6. Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3 Area 5)

Author: Bousquet, J, Farrell, J, Crooks, G, Hellings, P, Bel, E H, Bewick, M, Chavannes, N H, de Sousa, J Correia, Cruz, A A, Haahtela, T, Joos, G, Khaltaev, N, Malva, J, Muraro, A, Nogues, M, Palkonen, S, Pedersen, S, Robalo-Cordeiro, C, Samolinski, B, Strandberg, T, Valiulis, A, Yorgancioglu, A, Zuberbier, T, Bedbrook, A, Aberer, W, Adachi, M, Agusti, A, Akdis, C A, Akdis, M, Ankri, J, Alonso, A, Annesi-Maesano, I, Ansotegui, I J, Anto, J M, Arnavielhe, S, Arshad, H, Bai, C, Baiardini, I, Bachert, C, Baigenzhin, A K, Barbara, C, Bateman, E D, Beghé, B, Kheder, A Ben, Bennoor, K S, Benson, M, Bergmann, K C, Bieber, T, Bindslev-Jensen, C, Bjermer, L, Blain, H, Blasi, F, Boner, A L, Bonini, M, Bonini, S, Bosnic-Anticevitch, S, Boulet, L P, Bourret, R, Bousquet, P J, Braido, F, Briggs, A H, Brightling, C E, Brozek, J, Buhl, R, Burney, P G, Bush, A, Caballero-Fonseca, F, Caimmi, D, Calderon, M A, Calverley, P M, Camargos, P A M, Canonica, G W, Camuzat, T, Carlsen, K H, Carr, W, Carriazo, A, Casale, T, Cepeda Sarabia, A M, Chatzi, L, Chen, Y Z, Chiron, R, Chkhartishvili, E, Chuchalin, A G, Chung, K F, Ciprandi, G, Cirule, I, Cox, L, Costa, D J, Custovic, A, Dahl, R, Dahlen, S E, Darsow, U, De Carlo, G, De Blay, F, Dedeu, T, Deleanu, D, De Manuel Keenoy, E, Demoly, P, Denburg, J A, Devillier, P, Didier, A, Dinh-Xuan, A T, Djukanovic, R, Dokic, D, Douagui, H, Dray, G, Dubakiene, R, Durham, S R, Dykewicz, M S, El-Gamal, Y, Emuzyte, R, Fabbri, L M, Fletcher, M, Fiocchi, A, Fink Wagner, A, Fonseca, J, Fokkens, W J, Forastiere, F, Frith, P, Gaga, M, Gamkrelidze, A, Garces, J, Garcia-Aymerich, J, Gemicioğlu, B, Gereda, J E, González Diaz, S, Gotua, M, Grisle, I, Grouse, L, Gutter, Z, Guzmán, M A, Heaney, L G, Hellquist-Dahl, B, Henderson, D, Hendry, A, Heinrich, J, Heve, D, Horak, F, Hourihane, J O' B, Howarth, P, Humbert, M, Hyland, M E, Illario, M, Ivancevich, J C, Jardim, J R, Jares, E J, Jeandel, C, Jenkins, C, Johnston, S L, Jonquet, O, Julge, K, Jung, K S, Just, J, Kaidashev, I, Kaitov, M R, Kalayci, O, Kalyoncu, A F, Keil, T, Keith, P K, Klimek, L, Koffi N'Goran, B, Kolek, V, Koppelman, G H, Kowalski, M L, Kull, I, Kuna, P, Kvedariene, V, Lambrecht, B, Lau, S, Larenas-Linnemann, D, Laune, D, Le, L T T, Lieberman, P, Lipworth, B, Li, J, Lodrup Carlsen, K, Louis, R, MacNee, W, Magard, Y, Magnan, A, Mahboub, B, Mair, A, Majer, I, Makela, M J, Manning, P, Mara, S, Marshall, G D, Masjedi, M R, Matignon, P, Maurer, M, Mavale-Manuel, S, Melén, E, Melo-Gomes, E, Meltzer, E O, Menzies-Gow, A, Merk, H, Michel, J P, Miculinic, N, Mihaltan, F, Milenkovic, B, Mohammad, G M Y, Molimard, M, Momas, I, Montilla-Santana, A, Morais-Almeida, M, Morgan, M, Mösges, R, Mullol, J, Nafti, S, Namazova-Baranova, L, Naclerio, R, Neou, A, Neffen, H, Nekam, K, Niggemann, B, Ninot, G, Nyembue, T D, O'Hehir, R E, Ohta, K, Okamoto, Y, Okubo, K, Ouedraogo, S, Paggiaro, P, Pali-Schöll, I, Panzner, P, Papadopoulos, N, Papi, A, Park, H S, Passalacqua, G, Pavord, I, Pawankar, R, Pengelly, R, Pfaar, O, Picard, R, Pigearias, B, Pin, I, Plavec, D, Poethig, D, Pohl, W, Popov, T A, Portejoie, F, Potter, P, Postma, D., Price, D, Rabe, K F, Raciborski, F, Radier Pontal, F, Repka-Ramirez, S, Reitamo, S, Rennard, S, Rodenas, F, Roberts, J, Roca, J, Rodriguez Mañas, L, Rolland, C, Roman Rodriguez, M, Romano, A, Rosado-Pinto, J, Rosario, N, Rosenwasser, L, Rottem, M, Ryan, D, Sanchez-Borges, M, Scadding, G K, Schunemann, H J, Serrano, E, Schmid-Grendelmeier, P, Schulz, H, Sheikh, A, Shields, M, Siafakas, N, Sibille, Y, Similowski, T, Simons, F E R, Sisul, J C, Skrindo, I, Smit, H A, Solé, D, Sooronbaev, T, Spranger, O, Stelmach, R, Sterk, P J, Sunyer, J, Thijs, C, To, T, Todo-Bom, A, Triggiani, M, Valenta, R, Valero, A L, Valia, E, Valovirta, E, Van Ganse, E, van Hage, M, Vandenplas, O, Vasankari, T, Vellas, B, Vestbo, J, Vezzani, G, Vichyanond, P, Viegi, G, Vogelmeier, C, Vontetsianos, T, Wagenmann, M, Wallaert, B, Walker, S, Wang, D Y, Wahn, U, Wickman, M, Williams, D M, Williams, S, Wright, J, Yawn, B P, Yiallouros, P K, Yusuf, O M, Zaidi, A, Zar, H J, Zernotti, M E, Zhang, L, Zhong, N, Zidarn, M, Mercier, J, Bousquet, J, Farrell, J, Crooks, G, Hellings, P, Bel, E H, Bewick, M, Chavannes, N H, de Sousa, J Correia, Cruz, A A, Haahtela, T, Joos, G, Khaltaev, N, Malva, J, Muraro, A, Nogues, M, Palkonen, S, Pedersen, S, Robalo-Cordeiro, C, Samolinski, B, Strandberg, T, Valiulis, A, Yorgancioglu, A, Zuberbier, T, Bedbrook, A, Aberer, W, Adachi, M, Agusti, A, Akdis, C A, Akdis, M, Ankri, J, Alonso, A, Annesi-Maesano, I, Ansotegui, I J, Anto, J M, Arnavielhe, S, Arshad, H, Bai, C, Baiardini, I, Bachert, C, Baigenzhin, A K, Barbara, C, Bateman, E D, Beghé, B, Kheder, A Ben, Bennoor, K S, Benson, M, Bergmann, K C, Bieber, T, Bindslev-Jensen, C, Bjermer, L, Blain, H, Blasi, F, Boner, A L, Bonini, M, Bonini, S, Bosnic-Anticevitch, S, Boulet, L P, Bourret, R, Bousquet, P J, Braido, F, Briggs, A H, Brightling, C E, Brozek, J, Buhl, R, Burney, P G, Bush, A, Caballero-Fonseca, F, Caimmi, D, Calderon, M A, Calverley, P M, Camargos, P A M, Canonica, G W, Camuzat, T, Carlsen, K H, Carr, W, Carriazo, A, Casale, T, Cepeda Sarabia, A M, Chatzi, L, Chen, Y Z, Chiron, R, Chkhartishvili, E, Chuchalin, A G, Chung, K F, Ciprandi, G, Cirule, I, Cox, L, Costa, D J, Custovic, A, Dahl, R, Dahlen, S E, Darsow, U, De Carlo, G, De Blay, F, Dedeu, T, Deleanu, D, De Manuel Keenoy, E, Demoly, P, Denburg, J A, Devillier, P, Didier, A, Dinh-Xuan, A T, Djukanovic, R, Dokic, D, Douagui, H, Dray, G, Dubakiene, R, Durham, S R, Dykewicz, M S, El-Gamal, Y, Emuzyte, R, Fabbri, L M, Fletcher, M, Fiocchi, A, Fink Wagner, A, Fonseca, J, Fokkens, W J, Forastiere, F, Frith, P, Gaga, M, Gamkrelidze, A, Garces, J, Garcia-Aymerich, J, Gemicioğlu, B, Gereda, J E, González Diaz, S, Gotua, M, Grisle, I, Grouse, L, Gutter, Z, Guzmán, M A, Heaney, L G, Hellquist-Dahl, B, Henderson, D, Hendry, A, Heinrich, J, Heve, D, Horak, F, Hourihane, J O' B, Howarth, P, Humbert, M, Hyland, M E, Illario, M, Ivancevich, J C, Jardim, J R, Jares, E J, Jeandel, C, Jenkins, C, Johnston, S L, Jonquet, O, Julge, K, Jung, K S, Just, J, Kaidashev, I, Kaitov, M R, Kalayci, O, Kalyoncu, A F, Keil, T, Keith, P K, Klimek, L, Koffi N'Goran, B, Kolek, V, Koppelman, G H, Kowalski, M L, Kull, I, Kuna, P, Kvedariene, V, Lambrecht, B, Lau, S, Larenas-Linnemann, D, Laune, D, Le, L T T, Lieberman, P, Lipworth, B, Li, J, Lodrup Carlsen, K, Louis, R, MacNee, W, Magard, Y, Magnan, A, Mahboub, B, Mair, A, Majer, I, Makela, M J, Manning, P, Mara, S, Marshall, G D, Masjedi, M R, Matignon, P, Maurer, M, Mavale-Manuel, S, Melén, E, Melo-Gomes, E, Meltzer, E O, Menzies-Gow, A, Merk, H, Michel, J P, Miculinic, N, Mihaltan, F, Milenkovic, B, Mohammad, G M Y, Molimard, M, Momas, I, Montilla-Santana, A, Morais-Almeida, M, Morgan, M, Mösges, R, Mullol, J, Nafti, S, Namazova-Baranova, L, Naclerio, R, Neou, A, Neffen, H, Nekam, K, Niggemann, B, Ninot, G, Nyembue, T D, O'Hehir, R E, Ohta, K, Okamoto, Y, Okubo, K, Ouedraogo, S, Paggiaro, P, Pali-Schöll, I, Panzner, P, Papadopoulos, N, Papi, A, Park, H S, Passalacqua, G, Pavord, I, Pawankar, R, Pengelly, R, Pfaar, O, Picard, R, Pigearias, B, Pin, I, Plavec, D, Poethig, D, Pohl, W, Popov, T A, Portejoie, F, Potter, P, Postma, D., Price, D, Rabe, K F, Raciborski, F, Radier Pontal, F, Repka-Ramirez, S, Reitamo, S, Rennard, S, Rodenas, F, Roberts, J, Roca, J, Rodriguez Mañas, L, Rolland, C, Roman Rodriguez, M, Romano, A, Rosado-Pinto, J, Rosario, N, Rosenwasser, L, Rottem, M, Ryan, D, Sanchez-Borges, M, Scadding, G K, Schunemann, H J, Serrano, E, Schmid-Grendelmeier, P, Schulz, H, Sheikh, A, Shields, M, Siafakas, N, Sibille, Y, Similowski, T, Simons, F E R, Sisul, J C, Skrindo, I, Smit, H A, Solé, D, Sooronbaev, T, Spranger, O, Stelmach, R, Sterk, P J, Sunyer, J, Thijs, C, To, T, Todo-Bom, A, Triggiani, M, Valenta, R, Valero, A L, Valia, E, Valovirta, E, Van Ganse, E, van Hage, M, Vandenplas, O, Vasankari, T, Vellas, B, Vestbo, J, Vezzani, G, Vichyanond, P, Viegi, G, Vogelmeier, C, Vontetsianos, T, Wagenmann, M, Wallaert, B, Walker, S, Wang, D Y, Wahn, U, Wickman, M, Williams, D M, Williams, S, Wright, J, Yawn, B P, Yiallouros, P K, Yusuf, O M, Zaidi, A, Zar, H J, Zernotti, M E, Zhang, L, Zhong, N, Zidarn, M, and Mercier, J
Published: 2016

7. ARIA 2016 : Care pathways implementing emerging technologies for predictive medicine in rhinitis and asthma across the life cycle

Author: Bousquet, J, Hellings, P W, Agache, I, Bedbrook, A, Bachert, C, Bergmann, K C, Bewick, M, Bindslev-Jensen, C, Bosnic-Anticevitch, S, Bucca, C, Caimmi, D P, Camargos, P A M, Canonica, G W, Casale, T, Chavannes, N H, Cruz, A A, De Carlo, G, Dahl, R, Demoly, P, Devillier, P, Fonseca, J, Fokkens, W J, Guldemond, N A, Haahtela, T, Illario, M, Just, J, Keil, T, Klimek, L, Kuna, P, Larenas-Linnemann, D, Morais-Almeida, M, Mullol, J, Murray, R, Naclerio, R, O'Hehir, R E, Papadopoulos, N G, Pawankar, R, Potter, P, Ryan, D, Samolinski, B, Schunemann, H J, Sheikh, A, Simons, F E R, Stellato, C, Todo-Bom, A, Tomazic, P V, Valiulis, A, Valovirta, E, Ventura, M T, Wickman, M, Young, I, Yorgancioglu, A, Zuberbier, T, Aberer, W, Akdis, C A, Akdis, M, Annesi-Maesano, I, Ankri, J, Ansotegui, I J, Anto, J M, Arnavielhe, S, Asarnoj, A, Arshad, H, Avolio, F, Baiardini, I, Barbara, C, Barbagallo, M, Bateman, E D, Beghé, B, Bel, E H, Bennoor, K S, Benson, M, Białoszewski, A Z, Bieber, T, Bjermer, L, Blain, H, Blasi, F, Boner, A L, Bonini, M, Bonini, S, Bosse, I, Bouchard, J, Boulet, L P, Bourret, R, Bousquet, P J, Braido, F, Briggs, A H, Brightling, C E, Brozek, J, Buhl, R, Bunu, C, Burte, E, Bush, A, Caballero-Fonseca, F, Calderon, M A, Camuzat, T, Cardona, V, Carreiro-Martins, P, Carriazo, A M, Carlsen, K H, Carr, W, Cepeda Sarabia, A M, Cesari, M, Chatzi, L, Chiron, R, Chivato, T, Chkhartishvili, E, Chuchalin, A G, Chung, K F, Ciprandi, G, de Sousa, J Correia, Cox, L, Crooks, G, Custovic, A, Dahlen, S E, Darsow, U, Dedeu, T, Deleanu, D, Denburg, J A, De Vries, G, Didier, A, Dinh-Xuan, A T, Dokic, D, Douagui, H, Dray, G, Dubakiene, R, Durham, S R, Du Toit, G, Dykewicz, M S, Eklund, P, El-Gamal, Y, Ellers, E, Emuzyte, R, Farrell, J, Fink Wagner, A, Fiocchi, A, Fletcher, M, Forastiere, F, Gaga, M, Gamkrelidze, A, Gemicioğlu, B, Gereda, J E, van Wick, R Gerth, González Diaz, S, Grisle, I, Grouse, L, Gutter, Z, Guzmán, M A, Hellquist-Dahl, B, Heinrich, J, Horak, F, Hourihane, J O' B, Humbert, M, Hyland, M, Iaccarino, G, Jares, E J, Jeandel, C, Johnston, S L, Joos, G, Jonquet, O, Jung, K S, Jutel, M, Kaidashev, I, Khaitov, M, Kalayci, O, Kalyoncu, A F, Kardas, P, Keith, P K, Kerkhof, M, Kerstjens, H A M, Khaltaev, N, Kogevinas, M, Kolek, V, Koppelman, G H, Kowalski, M L, Kuitunen, M, Kull, I, Kvedariene, V, Lambrecht, B, Lau, S, Laune, D, Le, L T T, Lieberman, P, Lipworth, B, Li, J, Lodrup Carlsen, K C, Louis, R, Lupinek, C, MacNee, W, Magar, Y, Magnan, A, Mahboub, B, Maier, D, Majer, I, Malva, J, Manning, P, De Manuel Keenoy, E, Marshall, G D, Masjedi, M R, Mathieu-Dupas, E, Maurer, M, Mavale-Manuel, S, Melén, E, Melo-Gomes, E, Meltzer, E O, Mercier, J, Merk, H, Miculinic, N, Mihaltan, F, Milenkovic, B, Millot-Keurinck, J, Mohammad, Y, Momas, I, Mösges, R, Muraro, A, Namazova-Baranova, L, Nadif, R, Neffen, H, Nekam, K, Nieto, A, Niggemann, B, Nogueira-Silva, L, Nogues, M, Nyembue, T D, Ohta, K, Okamoto, Y, Okubo, K, Olive-Elias, M, Ouedraogo, S, Paggiaro, P, Pali-Schöll, I, Palkonen, S, Panzner, P, Papi, A, Park, H S, Passalacqua, G, Pedersen, S, Pereira, A M, Pfaar, O, Picard, R, Pigearias, B, Pin, I, Plavec, D, Pohl, W, Popov, T A, Portejoie, F, Postma, D, Poulsen, L K, Price, D, Rabe, K F, Raciborski, F, Roberts, G, Robalo-Cordeiro, C, Rodenas, F, Rodriguez-Mañas, L, Rolland, C, Roman Rodriguez, M, Romano, A, Rosado-Pinto, J, Rosario, N, Rottem, M, Sanchez-Borges, M, Sastre-Dominguez, J, Scadding, G K, Scichilone, N, Schmid-Grendelmeier, P, Serrano, E, Shields, M, Siroux, V, Sisul, J C, Skrindo, I, Smit, H A, Solé, D, Sooronbaev, T, Spranger, O, Stelmach, R, Sterk, P J, Strandberg, T, Sunyer, J, Thijs, C, Triggiani, M, Valenta, R, Valero, A, van Eerd, M, van Ganse, E, van Hague, M, Vandenplas, O, Varona, L L, Vellas, B, Vezzani, G, Vazankari, T, Viegi, G, Vontetsianos, T, Wagenmann, M, Walker, S, Wang, D Y, Wahn, U, Werfel, T, Whalley, B, Williams, D M, Williams, S, Wilson, N, Wright, J, Yawn, B P, Yiallouros, P K, Yusuf, O M, Zaidi, A, Zar, H J, Zernotti, M E, Zhang, L, Zhong, N, Zidarn, M, Bousquet, J, Hellings, P W, Agache, I, Bedbrook, A, Bachert, C, Bergmann, K C, Bewick, M, Bindslev-Jensen, C, Bosnic-Anticevitch, S, Bucca, C, Caimmi, D P, Camargos, P A M, Canonica, G W, Casale, T, Chavannes, N H, Cruz, A A, De Carlo, G, Dahl, R, Demoly, P, Devillier, P, Fonseca, J, Fokkens, W J, Guldemond, N A, Haahtela, T, Illario, M, Just, J, Keil, T, Klimek, L, Kuna, P, Larenas-Linnemann, D, Morais-Almeida, M, Mullol, J, Murray, R, Naclerio, R, O'Hehir, R E, Papadopoulos, N G, Pawankar, R, Potter, P, Ryan, D, Samolinski, B, Schunemann, H J, Sheikh, A, Simons, F E R, Stellato, C, Todo-Bom, A, Tomazic, P V, Valiulis, A, Valovirta, E, Ventura, M T, Wickman, M, Young, I, Yorgancioglu, A, Zuberbier, T, Aberer, W, Akdis, C A, Akdis, M, Annesi-Maesano, I, Ankri, J, Ansotegui, I J, Anto, J M, Arnavielhe, S, Asarnoj, A, Arshad, H, Avolio, F, Baiardini, I, Barbara, C, Barbagallo, M, Bateman, E D, Beghé, B, Bel, E H, Bennoor, K S, Benson, M, Białoszewski, A Z, Bieber, T, Bjermer, L, Blain, H, Blasi, F, Boner, A L, Bonini, M, Bonini, S, Bosse, I, Bouchard, J, Boulet, L P, Bourret, R, Bousquet, P J, Braido, F, Briggs, A H, Brightling, C E, Brozek, J, Buhl, R, Bunu, C, Burte, E, Bush, A, Caballero-Fonseca, F, Calderon, M A, Camuzat, T, Cardona, V, Carreiro-Martins, P, Carriazo, A M, Carlsen, K H, Carr, W, Cepeda Sarabia, A M, Cesari, M, Chatzi, L, Chiron, R, Chivato, T, Chkhartishvili, E, Chuchalin, A G, Chung, K F, Ciprandi, G, de Sousa, J Correia, Cox, L, Crooks, G, Custovic, A, Dahlen, S E, Darsow, U, Dedeu, T, Deleanu, D, Denburg, J A, De Vries, G, Didier, A, Dinh-Xuan, A T, Dokic, D, Douagui, H, Dray, G, Dubakiene, R, Durham, S R, Du Toit, G, Dykewicz, M S, Eklund, P, El-Gamal, Y, Ellers, E, Emuzyte, R, Farrell, J, Fink Wagner, A, Fiocchi, A, Fletcher, M, Forastiere, F, Gaga, M, Gamkrelidze, A, Gemicioğlu, B, Gereda, J E, van Wick, R Gerth, González Diaz, S, Grisle, I, Grouse, L, Gutter, Z, Guzmán, M A, Hellquist-Dahl, B, Heinrich, J, Horak, F, Hourihane, J O' B, Humbert, M, Hyland, M, Iaccarino, G, Jares, E J, Jeandel, C, Johnston, S L, Joos, G, Jonquet, O, Jung, K S, Jutel, M, Kaidashev, I, Khaitov, M, Kalayci, O, Kalyoncu, A F, Kardas, P, Keith, P K, Kerkhof, M, Kerstjens, H A M, Khaltaev, N, Kogevinas, M, Kolek, V, Koppelman, G H, Kowalski, M L, Kuitunen, M, Kull, I, Kvedariene, V, Lambrecht, B, Lau, S, Laune, D, Le, L T T, Lieberman, P, Lipworth, B, Li, J, Lodrup Carlsen, K C, Louis, R, Lupinek, C, MacNee, W, Magar, Y, Magnan, A, Mahboub, B, Maier, D, Majer, I, Malva, J, Manning, P, De Manuel Keenoy, E, Marshall, G D, Masjedi, M R, Mathieu-Dupas, E, Maurer, M, Mavale-Manuel, S, Melén, E, Melo-Gomes, E, Meltzer, E O, Mercier, J, Merk, H, Miculinic, N, Mihaltan, F, Milenkovic, B, Millot-Keurinck, J, Mohammad, Y, Momas, I, Mösges, R, Muraro, A, Namazova-Baranova, L, Nadif, R, Neffen, H, Nekam, K, Nieto, A, Niggemann, B, Nogueira-Silva, L, Nogues, M, Nyembue, T D, Ohta, K, Okamoto, Y, Okubo, K, Olive-Elias, M, Ouedraogo, S, Paggiaro, P, Pali-Schöll, I, Palkonen, S, Panzner, P, Papi, A, Park, H S, Passalacqua, G, Pedersen, S, Pereira, A M, Pfaar, O, Picard, R, Pigearias, B, Pin, I, Plavec, D, Pohl, W, Popov, T A, Portejoie, F, Postma, D, Poulsen, L K, Price, D, Rabe, K F, Raciborski, F, Roberts, G, Robalo-Cordeiro, C, Rodenas, F, Rodriguez-Mañas, L, Rolland, C, Roman Rodriguez, M, Romano, A, Rosado-Pinto, J, Rosario, N, Rottem, M, Sanchez-Borges, M, Sastre-Dominguez, J, Scadding, G K, Scichilone, N, Schmid-Grendelmeier, P, Serrano, E, Shields, M, Siroux, V, Sisul, J C, Skrindo, I, Smit, H A, Solé, D, Sooronbaev, T, Spranger, O, Stelmach, R, Sterk, P J, Strandberg, T, Sunyer, J, Thijs, C, Triggiani, M, Valenta, R, Valero, A, van Eerd, M, van Ganse, E, van Hague, M, Vandenplas, O, Varona, L L, Vellas, B, Vezzani, G, Vazankari, T, Viegi, G, Vontetsianos, T, Wagenmann, M, Walker, S, Wang, D Y, Wahn, U, Werfel, T, Whalley, B, Williams, D M, Williams, S, Wilson, N, Wright, J, Yawn, B P, Yiallouros, P K, Yusuf, O M, Zaidi, A, Zar, H J, Zernotti, M E, Zhang, L, Zhong, N, and Zidarn, M
Published: 2016

8. Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3 Area 5)

Author: Cardiometabolic Health, Circulatory Health, Child Health, JC onderzoeksprogramma Infectieziekten, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Bousquet, J, Farrell, J, Crooks, G, Hellings, P, Bel, E H, Bewick, M, Chavannes, N H, de Sousa, J Correia, Cruz, A A, Haahtela, T, Joos, G, Khaltaev, N, Malva, J, Muraro, A, Nogues, M, Palkonen, S, Pedersen, S, Robalo-Cordeiro, C, Samolinski, B, Strandberg, T, Valiulis, A, Yorgancioglu, A, Zuberbier, T, Bedbrook, A, Aberer, W, Adachi, M, Agusti, A, Akdis, C A, Akdis, M, Ankri, J, Alonso, A, Annesi-Maesano, I, Ansotegui, I J, Anto, J M, Arnavielhe, S, Arshad, H, Bai, C, Baiardini, I, Bachert, C, Baigenzhin, A K, Barbara, C, Bateman, E D, Beghé, B, Kheder, A Ben, Bennoor, K S, Benson, M, Bergmann, K C, Bieber, T, Bindslev-Jensen, C, Bjermer, L, Blain, H, Blasi, F, Boner, A L, Bonini, M, Bonini, S, Bosnic-Anticevitch, S, Boulet, L P, Bourret, R, Bousquet, P J, Braido, F, Briggs, A H, Brightling, C E, Brozek, J, Buhl, R, Burney, P G, Bush, A, Caballero-Fonseca, F, Caimmi, D, Calderon, M A, Calverley, P M, Camargos, P A M, Canonica, G W, Camuzat, T, Carlsen, K H, Carr, W, Carriazo, A, Casale, T, Cepeda Sarabia, A M, Chatzi, L, Chen, Y Z, Chiron, R, Chkhartishvili, E, Chuchalin, A G, Chung, K F, Ciprandi, G, Cirule, I, Cox, L, Costa, D J, Custovic, A, Dahl, R, Dahlen, S E, Darsow, U, De Carlo, G, De Blay, F, Dedeu, T, Deleanu, D, De Manuel Keenoy, E, Demoly, P, Denburg, J A, Devillier, P, Didier, A, Dinh-Xuan, A T, Djukanovic, R, Dokic, D, Douagui, H, Dray, G, Dubakiene, R, Durham, S R, Dykewicz, M S, El-Gamal, Y, Emuzyte, R, Fabbri, L M, Fletcher, M, Fiocchi, A, Fink Wagner, A, Fonseca, J, Fokkens, W J, Forastiere, F, Frith, P, Gaga, M, Gamkrelidze, A, Garces, J, Garcia-Aymerich, J, Gemicioğlu, B, Gereda, J E, González Diaz, S, Gotua, M, Grisle, I, Grouse, L, Gutter, Z, Guzmán, M A, Heaney, L G, Hellquist-Dahl, B, Henderson, D, Hendry, A, Heinrich, J, Heve, D, Horak, F, Hourihane, J O' B, Howarth, P, Humbert, M, Hyland, M E, Illario, M, Ivancevich, J C, Jardim, J R, Jares, E J, Jeandel, C, Jenkins, C, Johnston, S L, Jonquet, O, Julge, K, Jung, K S, Just, J, Kaidashev, I, Kaitov, M R, Kalayci, O, Kalyoncu, A F, Keil, T, Keith, P K, Klimek, L, Koffi N'Goran, B, Kolek, V, Koppelman, G H, Kowalski, M L, Kull, I, Kuna, P, Kvedariene, V, Lambrecht, B, Lau, S, Larenas-Linnemann, D, Laune, D, Le, L T T, Lieberman, P, Lipworth, B, Li, J, Lodrup Carlsen, K, Louis, R, MacNee, W, Magard, Y, Magnan, A, Mahboub, B, Mair, A, Majer, I, Makela, M J, Manning, P, Mara, S, Marshall, G D, Masjedi, M R, Matignon, P, Maurer, M, Mavale-Manuel, S, Melén, E, Melo-Gomes, E, Meltzer, E O, Menzies-Gow, A, Merk, H, Michel, J P, Miculinic, N, Mihaltan, F, Milenkovic, B, Mohammad, G M Y, Molimard, M, Momas, I, Montilla-Santana, A, Morais-Almeida, M, Morgan, M, Mösges, R, Mullol, J, Nafti, S, Namazova-Baranova, L, Naclerio, R, Neou, A, Neffen, H, Nekam, K, Niggemann, B, Ninot, G, Nyembue, T D, O'Hehir, R E, Ohta, K, Okamoto, Y, Okubo, K, Ouedraogo, S, Paggiaro, P, Pali-Schöll, I, Panzner, P, Papadopoulos, N, Papi, A, Park, H S, Passalacqua, G, Pavord, I, Pawankar, R, Pengelly, R, Pfaar, O, Picard, R, Pigearias, B, Pin, I, Plavec, D, Poethig, D, Pohl, W, Popov, T A, Portejoie, F, Potter, P, Postma, D., Price, D, Rabe, K F, Raciborski, F, Radier Pontal, F, Repka-Ramirez, S, Reitamo, S, Rennard, S, Rodenas, F, Roberts, J, Roca, J, Rodriguez Mañas, L, Rolland, C, Roman Rodriguez, M, Romano, A, Rosado-Pinto, J, Rosario, N, Rosenwasser, L, Rottem, M, Ryan, D, Sanchez-Borges, M, Scadding, G K, Schunemann, H J, Serrano, E, Schmid-Grendelmeier, P, Schulz, H, Sheikh, A, Shields, M, Siafakas, N, Sibille, Y, Similowski, T, Simons, F E R, Sisul, J C, Skrindo, I, Smit, H A, Solé, D, Sooronbaev, T, Spranger, O, Stelmach, R, Sterk, P J, Sunyer, J, Thijs, C, To, T, Todo-Bom, A, Triggiani, M, Valenta, R, Valero, A L, Valia, E, Valovirta, E, Van Ganse, E, van Hage, M, Vandenplas, O, Vasankari, T, Vellas, B, Vestbo, J, Vezzani, G, Vichyanond, P, Viegi, G, Vogelmeier, C, Vontetsianos, T, Wagenmann, M, Wallaert, B, Walker, S, Wang, D Y, Wahn, U, Wickman, M, Williams, D M, Williams, S, Wright, J, Yawn, B P, Yiallouros, P K, Yusuf, O M, Zaidi, A, Zar, H J, Zernotti, M E, Zhang, L, Zhong, N, Zidarn, M, Mercier, J, Cardiometabolic Health, Circulatory Health, Child Health, JC onderzoeksprogramma Infectieziekten, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Bousquet, J, Farrell, J, Crooks, G, Hellings, P, Bel, E H, Bewick, M, Chavannes, N H, de Sousa, J Correia, Cruz, A A, Haahtela, T, Joos, G, Khaltaev, N, Malva, J, Muraro, A, Nogues, M, Palkonen, S, Pedersen, S, Robalo-Cordeiro, C, Samolinski, B, Strandberg, T, Valiulis, A, Yorgancioglu, A, Zuberbier, T, Bedbrook, A, Aberer, W, Adachi, M, Agusti, A, Akdis, C A, Akdis, M, Ankri, J, Alonso, A, Annesi-Maesano, I, Ansotegui, I J, Anto, J M, Arnavielhe, S, Arshad, H, Bai, C, Baiardini, I, Bachert, C, Baigenzhin, A K, Barbara, C, Bateman, E D, Beghé, B, Kheder, A Ben, Bennoor, K S, Benson, M, Bergmann, K C, Bieber, T, Bindslev-Jensen, C, Bjermer, L, Blain, H, Blasi, F, Boner, A L, Bonini, M, Bonini, S, Bosnic-Anticevitch, S, Boulet, L P, Bourret, R, Bousquet, P J, Braido, F, Briggs, A H, Brightling, C E, Brozek, J, Buhl, R, Burney, P G, Bush, A, Caballero-Fonseca, F, Caimmi, D, Calderon, M A, Calverley, P M, Camargos, P A M, Canonica, G W, Camuzat, T, Carlsen, K H, Carr, W, Carriazo, A, Casale, T, Cepeda Sarabia, A M, Chatzi, L, Chen, Y Z, Chiron, R, Chkhartishvili, E, Chuchalin, A G, Chung, K F, Ciprandi, G, Cirule, I, Cox, L, Costa, D J, Custovic, A, Dahl, R, Dahlen, S E, Darsow, U, De Carlo, G, De Blay, F, Dedeu, T, Deleanu, D, De Manuel Keenoy, E, Demoly, P, Denburg, J A, Devillier, P, Didier, A, Dinh-Xuan, A T, Djukanovic, R, Dokic, D, Douagui, H, Dray, G, Dubakiene, R, Durham, S R, Dykewicz, M S, El-Gamal, Y, Emuzyte, R, Fabbri, L M, Fletcher, M, Fiocchi, A, Fink Wagner, A, Fonseca, J, Fokkens, W J, Forastiere, F, Frith, P, Gaga, M, Gamkrelidze, A, Garces, J, Garcia-Aymerich, J, Gemicioğlu, B, Gereda, J E, González Diaz, S, Gotua, M, Grisle, I, Grouse, L, Gutter, Z, Guzmán, M A, Heaney, L G, Hellquist-Dahl, B, Henderson, D, Hendry, A, Heinrich, J, Heve, D, Horak, F, Hourihane, J O' B, Howarth, P, Humbert, M, Hyland, M E, Illario, M, Ivancevich, J C, Jardim, J R, Jares, E J, Jeandel, C, Jenkins, C, Johnston, S L, Jonquet, O, Julge, K, Jung, K S, Just, J, Kaidashev, I, Kaitov, M R, Kalayci, O, Kalyoncu, A F, Keil, T, Keith, P K, Klimek, L, Koffi N'Goran, B, Kolek, V, Koppelman, G H, Kowalski, M L, Kull, I, Kuna, P, Kvedariene, V, Lambrecht, B, Lau, S, Larenas-Linnemann, D, Laune, D, Le, L T T, Lieberman, P, Lipworth, B, Li, J, Lodrup Carlsen, K, Louis, R, MacNee, W, Magard, Y, Magnan, A, Mahboub, B, Mair, A, Majer, I, Makela, M J, Manning, P, Mara, S, Marshall, G D, Masjedi, M R, Matignon, P, Maurer, M, Mavale-Manuel, S, Melén, E, Melo-Gomes, E, Meltzer, E O, Menzies-Gow, A, Merk, H, Michel, J P, Miculinic, N, Mihaltan, F, Milenkovic, B, Mohammad, G M Y, Molimard, M, Momas, I, Montilla-Santana, A, Morais-Almeida, M, Morgan, M, Mösges, R, Mullol, J, Nafti, S, Namazova-Baranova, L, Naclerio, R, Neou, A, Neffen, H, Nekam, K, Niggemann, B, Ninot, G, Nyembue, T D, O'Hehir, R E, Ohta, K, Okamoto, Y, Okubo, K, Ouedraogo, S, Paggiaro, P, Pali-Schöll, I, Panzner, P, Papadopoulos, N, Papi, A, Park, H S, Passalacqua, G, Pavord, I, Pawankar, R, Pengelly, R, Pfaar, O, Picard, R, Pigearias, B, Pin, I, Plavec, D, Poethig, D, Pohl, W, Popov, T A, Portejoie, F, Potter, P, Postma, D., Price, D, Rabe, K F, Raciborski, F, Radier Pontal, F, Repka-Ramirez, S, Reitamo, S, Rennard, S, Rodenas, F, Roberts, J, Roca, J, Rodriguez Mañas, L, Rolland, C, Roman Rodriguez, M, Romano, A, Rosado-Pinto, J, Rosario, N, Rosenwasser, L, Rottem, M, Ryan, D, Sanchez-Borges, M, Scadding, G K, Schunemann, H J, Serrano, E, Schmid-Grendelmeier, P, Schulz, H, Sheikh, A, Shields, M, Siafakas, N, Sibille, Y, Similowski, T, Simons, F E R, Sisul, J C, Skrindo, I, Smit, H A, Solé, D, Sooronbaev, T, Spranger, O, Stelmach, R, Sterk, P J, Sunyer, J, Thijs, C, To, T, Todo-Bom, A, Triggiani, M, Valenta, R, Valero, A L, Valia, E, Valovirta, E, Van Ganse, E, van Hage, M, Vandenplas, O, Vasankari, T, Vellas, B, Vestbo, J, Vezzani, G, Vichyanond, P, Viegi, G, Vogelmeier, C, Vontetsianos, T, Wagenmann, M, Wallaert, B, Walker, S, Wang, D Y, Wahn, U, Wickman, M, Williams, D M, Williams, S, Wright, J, Yawn, B P, Yiallouros, P K, Yusuf, O M, Zaidi, A, Zar, H J, Zernotti, M E, Zhang, L, Zhong, N, Zidarn, M, and Mercier, J
Published: 2016

9. Genes associated with polymorphic variants predicting lung function are differentially expressed during human lung development.

Author: Miller, S., Melén, E., Merid, S. K., Hall, I. P., and Sayers, I.
Subjects: *LUNG development, *PULMONARY function tests, *GENE expression, *SINGLE nucleotide polymorphisms, *IMMUNOHISTOCHEMISTRY, *LUNG physiology, *PROTEIN metabolism, *RNA metabolism, *CARRIER proteins, *DATABASES, *GENES, *GENETIC polymorphisms, *GESTATIONAL age, *LUNGS, *MEMBRANE proteins, *PROTEINS, *RESEARCH funding, *RNA, *PHENOTYPES, *OLIGONUCLEOTIDE arrays, *MEMBRANE glycoproteins, *GENE expression profiling, *GENOTYPES, *CELL cycle proteins
Abstract: Background: Recent meta-analyses of genome-wide association studies have identified single nucleotide polymorphisms (SNPs) within/near 54 genes associated with lung function measures. Current understanding of the contribution of these genes to human lung development is limited. We set out to further define i) the expression profile of these genes during human lung development using a unique set of resources to examine both mRNA and protein expression and ii) the link between key polymorphisms and genes using expression quantitative trait loci (eQTL) approaches.Methods: The mRNA expression profile of lung function associated genes across pseudoglandular and canalicular stages of lung development were determined using expression array data of 38 human fetal lungs. eQTLs were investigated for selected genes using blood cell and lung tissue data. Immunohistochemistry of the top 5 candidates was performed in a panel of 24 fetal lung samples.Results: Twenty-nine lung function associated genes were differentially expressed during lung development at the mRNA level. The greatest magnitude of effect was observed for 5 genes; TMEM163, FAM13A and HHIP which had increasing expression and CDC123 and PTCH1 with decreased expression across developmental stages. Focussed eQTL analyses investigating SNPs in these five loci identified several cis-eQTL's. Protein expression of TMEM163 increased and CDC123 decreased with fetal lung age in agreement with mRNA data. Protein expression in FAM13A, HHIP and PTCH1 remained relatively constant throughout lung development.Conclusions: We have identified that > 50 % of lung function associated genes show evidence of differential expression during lung development and we show that in particular TMEM163 and CDC123 are differentially expressed at both the mRNA and protein levels. Our data provides a systematic evaluation of lung function associated genes in this context and offers some insight into the potential role of several of these genes in contributing to human lung development. [ABSTRACT FROM AUTHOR]
Published: 2016
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10. BMI trajectories from birth to young adulthood associate with distinct cardiometabolic profiles.

Author: Wang G, Wei D, Kebede Merid S, Ekström S, Klevebro S, Hernandez-Pacheco N, Björkander S, Ljungman P, Kull I, Schwenk JM, Bergström A, and Melén E
Subjects: Humans, Male, Female, Sweden epidemiology, Young Adult, Adolescent, Child, Adult, Cardiovascular Diseases epidemiology, Cardiovascular Diseases blood, Child, Preschool, Infant, Newborn, Infant, Blood Pressure physiology, Birth Cohort, Lipids blood, Cardiometabolic Risk Factors, Glycated Hemoglobin analysis, Glycated Hemoglobin metabolism, Body Mass Index
Abstract: Background: Numerous studies have investigated links between body mass index (BMI) trajectories and cardiovascular risk, yet discrepancies in BMI measurement duration and timing of the cardiovascular-related outcome evaluation have led to inconsistent findings., Methods: We included participants from the Swedish birth cohort (BAMSE) and applied latent class mixture modeling to identify BMI trajectories using data of multiple BMI measures (≥ 4 times) from birth until 24-year follow-up (n = 3204). Subsequently, we analyzed the associations of BMI trajectories with lipids (n = 1974), blood pressure (n = 2022), HbA1c (n = 941), and blood leukocytes (n = 1973) using linear regression. We also investigated the circulating levels of 92 inflammation-related proteins (n = 1866) across BMI trajectories., Results: Six distinct BMI groups were identified, denoted as increasing-persistent high (n = 74; 2.3%), high-accelerated increasing (n = 209; 6.5%), increasing-accelerated resolving (n = 142; 4.4%), normal-above normal (n = 721; 22.5%), stable normal (n = 1608; 50.2%), and decreasing-persistent low (n = 450; 14.1%) BMI groups. The increasing-persistent high and high-accelerated increasing BMI groups had higher levels of total cholesterol [mean difference (95% confidence intervals): 0.30 (0.04-0.56) and 0.16 (0.02-0.31) mmol/L], triglyceride, low-density lipoprotein, hemoglobin A1C [3.61 (2.17-5.54) and 1.18 (0.40-1.98) mmol/mol], and low-density lipoprotein/high-density lipoprotein ratios, but a lower level of high-density lipoprotein than the stable normal BMI group. These two groups also had higher leukocyte cell counts and higher circulating levels of 28 inflammation-related proteins. No increased cardiometabolic markers were observed in the increasing-accelerated resolving BMI group., Conclusions: Participants with persistently high or accelerated increasing BMI trajectories from birth to young adulthood have elevated levels of cardiometabolic risk markers at young adulthood than those with stable normal BMI. However, a raised BMI in childhood may not be inherently harmful to cardiometabolic health, provided it does not persist into adulthood., (© 2024. The Author(s).)
Published: 2024
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11. Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude.

Author: Kadalayil L, Alam MZ, White CH, Ghantous A, Walton E, Gruzieva O, Merid SK, Kumar A, Roy RP, Solomon O, Huen K, Eskenazi B, Rzehak P, Grote V, Langhendries JP, Verduci E, Ferre N, Gruszfeld D, Gao L, Guan W, Zeng X, Schisterman EF, Dou JF, Bakulski KM, Feinberg JI, Soomro MH, Pesce G, Baiz N, Isaevska E, Plusquin M, Vafeiadi M, Roumeliotaki T, Langie SAS, Standaert A, Allard C, Perron P, Bouchard L, van Meel ER, Felix JF, Jaddoe VWV, Yousefi PD, Ramlau-Hansen CH, Relton CL, Tobi EW, Starling AP, Yang IV, Llambrich M, Santorelli G, Lepeule J, Salas LA, Bustamante M, Ewart SL, Zhang H, Karmaus W, Röder S, Zenclussen AC, Jin J, Nystad W, Page CM, Magnus M, Jima DD, Hoyo C, Maguire RL, Kvist T, Czamara D, Räikkönen K, Gong T, Ullemar V, Rifas-Shiman SL, Oken E, Almqvist C, Karlsson R, Lahti J, Murphy SK, Håberg SE, London S, Herberth G, Arshad H, Sunyer J, Grazuleviciene R, Dabelea D, Steegers-Theunissen RPM, Nohr EA, Sørensen TIA, Duijts L, Hivert MF, Nelen V, Popovic M, Kogevinas M, Nawrot TS, Herceg Z, Annesi-Maesano I, Fallin MD, Yeung E, Breton CV, Koletzko B, Holland N, Wiemels JL, Melén E, Sharp GC, Silver MJ, Rezwan FI, and Holloway JW
Subjects: Child, Child, Preschool, Humans, Infant, Infant, Newborn, Carcinogenesis, Inflammation, Seasons, Asthma, DNA Methylation
Abstract: Background: Seasonal variations in environmental exposures at birth or during gestation are associated with numerous adult traits and health outcomes later in life. Whether DNA methylation (DNAm) plays a role in the molecular mechanisms underlying the associations between birth season and lifelong phenotypes remains unclear., Methods: We carried out epigenome-wide meta-analyses within the Pregnancy And Childhood Epigenetic Consortium to identify associations of DNAm with birth season, both at differentially methylated probes (DMPs) and regions (DMRs). Associations were examined at two time points: at birth (21 cohorts, N = 9358) and in children aged 1-11 years (12 cohorts, N = 3610). We conducted meta-analyses to assess the impact of latitude on birth season-specific associations at both time points., Results: We identified associations between birth season and DNAm (False Discovery Rate-adjusted p values < 0.05) at two CpGs at birth (winter-born) and four in the childhood (summer-born) analyses when compared to children born in autumn. Furthermore, we identified twenty-six differentially methylated regions (DMR) at birth (winter-born: 8, spring-born: 15, summer-born: 3) and thirty-two in childhood (winter-born: 12, spring and summer: 10 each) meta-analyses with few overlapping DMRs between the birth seasons or the two time points. The DMRs were associated with genes of known functions in tumorigenesis, psychiatric/neurological disorders, inflammation, or immunity, amongst others. Latitude-stratified meta-analyses [higher (≥ 50°N), lower (< 50°N, northern hemisphere only)] revealed differences in associations between birth season and DNAm by birth latitude. DMR analysis implicated genes with previously reported links to schizophrenia (LAX1), skin disorders (PSORS1C, LTB4R), and airway inflammation including asthma (LTB4R), present only at birth in the higher latitudes (≥ 50°N)., Conclusions: In this large epigenome-wide meta-analysis study, we provide evidence for (i) associations between DNAm and season of birth that are unique for the seasons of the year (temporal effect) and (ii) latitude-dependent variations in the seasonal associations (spatial effect). DNAm could play a role in the molecular mechanisms underlying the effect of birth season on adult health outcomes., (© 2023. BioMed Central Ltd., part of Springer Nature.)
Published: 2023
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12. Changes in lifestyle, adiposity, and cardiometabolic markers among young adults in Sweden during the COVID-19 pandemic.

Author: Ekström S, Andersson N, Kull I, Georgelis A, Ljungman PLS, Melén E, and Bergström A
Subjects: Female, Male, Humans, Young Adult, Adult, Adiposity, Pandemics, Sweden epidemiology, Obesity, Life Style, Body Mass Index, Risk Factors, COVID-19 epidemiology, Cardiovascular Diseases epidemiology
Abstract: Background: The COVID-19 pandemic has impacted on public health in several ways. The aim of the study was to investigate changes in lifestyle, adiposity, and cardiometabolic markers among young adults in Sweden during the COVID-19 pandemic and their determinants., Methods: The study included 1 004 participants from the population-based birth cohort BAMSE. Anthropometrics, body composition (bioelectric impedance analyses), pulse, and blood pressure were measured before (December 2016-May 2019; mean age 22.6 years) and during (October 2020-June 2021; mean age 25.7 years) the COVID-19 pandemic. Lifestyle changes during the pandemic were assessed through a questionnaire., Results: All measures of adiposity (weight, BMI, body fat percentage, trunk fat percentage) and cardiometabolic markers (blood pressure, pulse) increased during the study period (e.g., body fat percentage by a median of + 0.8% in females, p < 0.001, and + 1.5% in males, p < 0.001). Male sex, non-Scandinavian ethnicity, BMI status (underweight and obesity), and changes in lifestyle factors, e.g., decreased physical activity during the pandemic, were associated with higher increase in BMI and/or adiposity., Conclusion: Lifestyle factors, adiposity and cardiometabolic markers may have been adversely affected among young adults in Sweden during the COVID-19 pandemic compared with the preceding years. Targeted public health measures to reduce obesity and improve healthy lifestyle are important to prevent future non-communicable diseases., (© 2023. The Author(s).)
Published: 2023
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13. Health-related quality of life decreases in young people with asthma during the transition from adolescence to young adulthood: a birth cohort study.

Author: Ödling M, Andersson N, Janson C, Melén E, Bergström A, and Kull I
Subjects: Young Adult, Humans, Adolescent, Child, Adult, Cohort Studies, Prospective Studies, Cross-Sectional Studies, Surveys and Questionnaires, Health Status, Quality of Life, Asthma epidemiology
Abstract: Background: During the transition from paediatric to adult healthcare there is a gap between asthma guidelines and actual management with decreased healthcare consultations and dispensations of asthma medications after the transition to adult healthcare among young people with asthma. How health-related quality of life (HRQoL) develops during the transition from adolescence to young adulthood is unclear. Our aim was therefore to investigate HRQoL among young people with asthma during the transition to adulthood. Further, to assess if level of asthma control and physical activity influence any potential association between asthma and HRQoL., Methods: The study population consisted of 2268 participants from the ongoing Swedish population-based prospective birth cohort BAMSE (Barn/Child, Allergy, Milieu, Stockholm, Epidemiology). HRQoL was measured using the instrument EQ-5D-3 L and three general questions. The EQ-5D-3 L consists of the EQ-5D descriptive system and the EQ visual analogue scale (EQ VAS). The EQ-5D-3 L instrument and questions on general health, symptoms and treatment of asthma, and lifestyle factors were based on data from follow-ups at 16 and 24 years. Cross-sectional analyses were made., Results: At the 24-year follow-up, the adjusted median values of EQ VAS were lower compared with at the 16-year follow-up; among both participants with asthma (80 vs. 85, p < 0.01) and those without asthma (80 vs. 87, p < 0.01). At the 24-year follow-up, participants with uncontrolled asthma had a lower adjusted median EQ VAS score than peers with controlled/partly controlled asthma (75 vs. 80, p = 0.03). Further, young adults with asthma who did not fulfil the WHO recommendations on physical activity had lower EQ VAS scores than peers who did (70 vs. 80, p < 0.01)., Conclusion: HRQoL is lower in young adulthood than in adolescence. Young adults with asthma having uncontrolled disease or who are physically inactive appear to be particularly vulnerable., (© 2023. The Author(s).)
Published: 2023
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14. DNA methylation and aeroallergen sensitization: The chicken or the egg?

Author: Kilanowski A, Merid SK, Abrishamcar S, Feil D, Thiering E, Waldenberger M, Melén E, Peters A, Standl M, and Hüls A
Subjects: Biomarkers, Cross-Sectional Studies, Female, Humans, Immunoglobulin E, Pregnancy, DNA Methylation, Hypersensitivity genetics
Abstract: Background: DNA methylation (DNAm) is considered a plausible pathway through which genetic and environmental factors may influence the development of allergies. However, causality has yet to be determined as it is unknown whether DNAm is rather a cause or consequence of allergic sensitization. Here, we investigated the direction of the observed associations between well-known environmental and genetic determinants of allergy, DNAm, and aeroallergen sensitization using a combination of high-dimensional and causal mediation analyses., Methods: Using prospectively collected data from the German LISA birth cohort from two time windows (6-10 years: N = 234; 10-15 years: N = 167), we tested whether DNAm is a cause or a consequence of aeroallergen sensitization (specific immunoglobulin E > 0.35kU/l) by conducting mediation analyses for both effect directions using maternal smoking during pregnancy, family history of allergies, and a polygenic risk score (PRS) for any allergic disease as exposure variables. We evaluated individual CpG sites (EPIC BeadChip) and allergy-related methylation risk scores (MRS) as potential mediators in the mediation analyses. We applied three high-dimensional mediation approaches (HIMA, DACT, gHMA) and validated results using causal mediation analyses. A replication of results was attempted in the Swedish BAMSE cohort., Results: Using high-dimensional methods, we identified five CpGs as mediators of prenatal exposures to sensitization with significant (adjusted p < 0.05) indirect effects in the causal mediation analysis (maternal smoking: two CpGs, family history: one, PRS: two). None of these CpGs could be replicated in BAMSE. The effect of family history on allergy-related MRS was significantly mediated by aeroallergen sensitization (proportions mediated: 33.7-49.6%), suggesting changes in DNAm occurred post-sensitization., Conclusion: The results indicate that DNAm may be a cause or consequence of aeroallergen sensitization depending on genomic location. Allergy-related MRS, identified as a potential cause of sensitization, can be considered as a cross-sectional biomarker of disease. Differential DNAm in individual CpGs, identified as mediators of the development of sensitization, could be used as clinical predictors of disease development., (© 2022. The Author(s).)
Published: 2022
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15. Immunoprofiling of active and inactive systemic juvenile idiopathic arthritis reveals distinct biomarkers: a single-center study.

Author: Qu H, Sundberg E, Aulin C, Neog M, Palmblad K, Horne AC, Granath F, Ek A, Melén E, Olsson M, and Harris HE
Subjects: Adolescent, Child, Child, Preschool, Cross-Sectional Studies, Female, Humans, Male, Proteomics, Arthritis, Juvenile blood, Arthritis, Juvenile immunology, Biomarkers blood
Abstract: Background: This study aimed to perform an immunoprofiling of systemic juvenile idiopathic arthritis (sJIA) in order to define biomarkers of clinical use as well as reveal new immune mechanisms., Methods: Immunoprofiling of plasma samples from a clinically well-described cohort consisting of 21 sJIA patients as well as 60 age and sex matched healthy controls, was performed by a highly sensitive proteomic immunoassay. Based on the biomarkers being significantly up- or down-regulated in cross-sectional and paired analysis, related canonical pathways and cellular functions were explored by Ingenuity Pathway Analysis (IPA)., Results: The well-studied sJIA biomarkers, IL6, IL18 and S100A12, were confirmed to be increased during active sJIA as compared to healthy controls. IL18 was the only factor found to be increased during inactive sJIA as compared to healthy controls. Novel factors, including CASP8, CCL23, CD6, CXCL1, CXCL11, CXCL5, EIF4EBP1, KITLG, MMP1, OSM, SIRT2, SULT1A1 and TNFSF11, were found to be differentially expressed in active and/or inactive sJIA and healthy controls. No significant pathway activation could be predicted based on the limited factor input to the IPA. High Mobility Group Box 1 (HMGB1), a damage associated molecular pattern being involved in a series of inflammatory diseases, was determined to be higher in active sJIA than inactive sJIA., Conclusions: We could identify a novel set of biomarkers distinguishing active sJIA from inactive sJIA or healthy controls. Our findings enable a better understanding of the immune mechanisms active in sJIA and aid the development of future diagnostic and therapeutic strategies., (© 2021. The Author(s).)
Published: 2021
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16. DNA methylation and body mass index from birth to adolescence: meta-analyses of epigenome-wide association studies.

Author: Vehmeijer FOL, Küpers LK, Sharp GC, Salas LA, Lent S, Jima DD, Tindula G, Reese S, Qi C, Gruzieva O, Page C, Rezwan FI, Melton PE, Nohr E, Escaramís G, Rzehak P, Heiskala A, Gong T, Tuominen ST, Gao L, Ross JP, Starling AP, Holloway JW, Yousefi P, Aasvang GM, Beilin LJ, Bergström A, Binder E, Chatzi L, Corpeleijn E, Czamara D, Eskenazi B, Ewart S, Ferre N, Grote V, Gruszfeld D, Håberg SE, Hoyo C, Huen K, Karlsson R, Kull I, Langhendries JP, Lepeule J, Magnus MC, Maguire RL, Molloy PL, Monnereau C, Mori TA, Oken E, Räikkönen K, Rifas-Shiman S, Ruiz-Arenas C, Sebert S, Ullemar V, Verduci E, Vonk JM, Xu CJ, Yang IV, Zhang H, Zhang W, Karmaus W, Dabelea D, Muhlhausler BS, Breton CV, Lahti J, Almqvist C, Jarvelin MR, Koletzko B, Vrijheid M, Sørensen TIA, Huang RC, Arshad SH, Nystad W, Melén E, Koppelman GH, London SJ, Holland N, Bustamante M, Murphy SK, Hivert MF, Baccarelli A, Relton CL, Snieder H, Jaddoe VWV, and Felix JF
Subjects: Adolescent, Child, Child, Preschool, CpG Islands, Cross-Sectional Studies, Epigenome, Female, Fetal Blood, Humans, Male, Pediatric Obesity genetics, Pregnancy, Body Mass Index, DNA Methylation, Epigenesis, Genetic, Obesity genetics, Parturition
Abstract: Background: DNA methylation has been shown to be associated with adiposity in adulthood. However, whether similar DNA methylation patterns are associated with childhood and adolescent body mass index (BMI) is largely unknown. More insight into this relationship at younger ages may have implications for future prevention of obesity and its related traits., Methods: We examined whether DNA methylation in cord blood and whole blood in childhood and adolescence was associated with BMI in the age range from 2 to 18 years using both cross-sectional and longitudinal models. We performed meta-analyses of epigenome-wide association studies including up to 4133 children from 23 studies. We examined the overlap of findings reported in previous studies in children and adults with those in our analyses and calculated enrichment., Results: DNA methylation at three CpGs (cg05937453, cg25212453, and cg10040131), each in a different age range, was associated with BMI at Bonferroni significance, P < 1.06 × 10 -7 , with a 0.96 standard deviation score (SDS) (standard error (SE) 0.17), 0.32 SDS (SE 0.06), and 0.32 BMI SDS (SE 0.06) higher BMI per 10% increase in methylation, respectively. DNA methylation at nine additional CpGs in the cross-sectional childhood model was associated with BMI at false discovery rate significance. The strength of the associations of DNA methylation at the 187 CpGs previously identified to be associated with adult BMI, increased with advancing age across childhood and adolescence in our analyses. In addition, correlation coefficients between effect estimates for those CpGs in adults and in children and adolescents also increased. Among the top findings for each age range, we observed increasing enrichment for the CpGs that were previously identified in adults (birth P enrichment = 1; childhood P enrichment = 2.00 × 10 -4 ; adolescence P enrichment = 2.10 × 10 -7 )., Conclusions: There were only minimal associations of DNA methylation with childhood and adolescent BMI. With the advancing age of the participants across childhood and adolescence, we observed increasing overlap with altered DNA methylation loci reported in association with adult BMI. These findings may be compatible with the hypothesis that DNA methylation differences are mostly a consequence rather than a cause of obesity.
Published: 2020
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17. Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age.

Author: Merid SK, Novoloaca A, Sharp GC, Küpers LK, Kho AT, Roy R, Gao L, Annesi-Maesano I, Jain P, Plusquin M, Kogevinas M, Allard C, Vehmeijer FO, Kazmi N, Salas LA, Rezwan FI, Zhang H, Sebert S, Czamara D, Rifas-Shiman SL, Melton PE, Lawlor DA, Pershagen G, Breton CV, Huen K, Baiz N, Gagliardi L, Nawrot TS, Corpeleijn E, Perron P, Duijts L, Nohr EA, Bustamante M, Ewart SL, Karmaus W, Zhao S, Page CM, Herceg Z, Jarvelin MR, Lahti J, Baccarelli AA, Anderson D, Kachroo P, Relton CL, Bergström A, Eskenazi B, Soomro MH, Vineis P, Snieder H, Bouchard L, Jaddoe VW, Sørensen TIA, Vrijheid M, Arshad SH, Holloway JW, Håberg SE, Magnus P, Dwyer T, Binder EB, DeMeo DL, Vonk JM, Newnham J, Tantisira KG, Kull I, Wiemels JL, Heude B, Sunyer J, Nystad W, Munthe-Kaas MC, Räikkönen K, Oken E, Huang RC, Weiss ST, Antó JM, Bousquet J, Kumar A, Söderhäll C, Almqvist C, Cardenas A, Gruzieva O, Xu CJ, Reese SE, Kere J, Brodin P, Solomon O, Wielscher M, Holland N, Ghantous A, Hivert MF, Felix JF, Koppelman GH, London SJ, and Melén E
Subjects: Adolescent, Child, Child, Preschool, DNA blood, Female, Genetic Loci, Humans, Infant, Newborn, Infant, Premature, Male, DNA Methylation, Epigenome, Fetal Development genetics, Premature Birth genetics
Abstract: Background: Preterm birth and shorter duration of pregnancy are associated with increased morbidity in neonatal and later life. As the epigenome is known to have an important role during fetal development, we investigated associations between gestational age and blood DNA methylation in children., Methods: We performed meta-analysis of Illumina's HumanMethylation450-array associations between gestational age and cord blood DNA methylation in 3648 newborns from 17 cohorts without common pregnancy complications, induced delivery or caesarean section. We also explored associations of gestational age with DNA methylation measured at 4-18 years in additional pediatric cohorts. Follow-up analyses of DNA methylation and gene expression correlations were performed in cord blood. DNA methylation profiles were also explored in tissues relevant for gestational age health effects: fetal brain and lung., Results: We identified 8899 CpGs in cord blood that were associated with gestational age (range 27-42 weeks), at Bonferroni significance, P < 1.06 × 10 - 7 , of which 3343 were novel. These were annotated to 4966 genes. After restricting findings to at least three significant adjacent CpGs, we identified 1276 CpGs annotated to 325 genes. Results were generally consistent when analyses were restricted to term births. Cord blood findings tended not to persist into childhood and adolescence. Pathway analyses identified enrichment for biological processes critical to embryonic development. Follow-up of identified genes showed correlations between gestational age and DNA methylation levels in fetal brain and lung tissue, as well as correlation with expression levels., Conclusions: We identified numerous CpGs differentially methylated in relation to gestational age at birth that appear to reflect fetal developmental processes across tissues. These findings may contribute to understanding mechanisms linking gestational age to health effects.
Published: 2020
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18. Lung function development after preterm birth in relation to severity of Bronchopulmonary dysplasia.

Author: Um-Bergström P, Hallberg J, Thunqvist P, Berggren-Broström E, Anderson M, Adenfelt G, Lilja G, Ferrara G, Sköld CM, and Melén E
Subjects: Adolescent, Child, Exercise Test, Exercise Tolerance, Female, Forced Expiratory Volume, Humans, Infant, Newborn, Longitudinal Studies, Male, Oscillometry, Oxygen Consumption, Plethysmography, Severity of Illness Index, Spirometry, Vital Capacity, Bronchopulmonary Dysplasia physiopathology, Premature Birth physiopathology, Respiratory Distress Syndrome, Newborn physiopathology
Abstract: Background: Bronchopulmonary dysplasia (BPD) is a strong risk factor for respiratory morbidity in children born preterm. Our aims were to evaluate lung function in adolescents born preterm with and without a history of BPD, and to assess lung function change over time from school age., Methods: Fifty-one individuals born in Stockholm, Sweden between gestational ages 24 to 31 weeks (23 neonatally diagnosed with respiratory distress syndrome (RDS) but not BPD, and 28 graded as mild (n = 17), moderate (n = 7) or severe (n = 4) BPD) were examined in adolescence (13-17 years of age) using spirometry, impulse oscillometry (IOS), plethysmography, and ergospirometry. Comparison with lung function data from school age (6-8 years of age) was also performed., Results: Adolescents with a history of BPD had lower forced expiratory volume in 1 s (FEV 1 ) compared to those without BPD (-0.61 vs.-0.02 z-scores, P < 0.05), with lower FEV 1 values significantly associated with BPD severity (P for trend 0.002). Subjects with severe BPD had higher frequency dependence of resistance, R 5-20 , (P < 0.001 vs. non-BPD subjects) which is an IOS indicator of peripheral airway involvement. Between school age and adolescence, FEV 1 /FVC z-scores decreased in all groups and particularly in the severe BPD group (from -1.68 z-scores at 6-8 years to -2.74 z-scores at 13-17 years, p < 0.05 compared to the non-BPD group)., Conclusions: Our results of spirometry and IOS measures in the BPD groups compared to the non-BPD group suggest airway obstruction including involvement of peripheral airways. The longitudinal result of a decrease in FEV 1 /FVC in the group with severe BPD might implicate a route towards chronic airway obstruction in adulthood.
Published: 2017
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19. The emerging landscape of dynamic DNA methylation in early childhood.

Author: Xu CJ, Bonder MJ, Söderhäll C, Bustamante M, Baïz N, Gehring U, Jankipersadsing SA, van der Vlies P, van Diemen CC, van Rijkom B, Just J, Kull I, Kere J, Antó JM, Bousquet J, Zhernakova A, Wijmenga C, Annesi-Maesano I, Sunyer J, Melén E, Li Y, Postma DS, and Koppelman GH
Subjects: Child, Child, Preschool, CpG Islands, Female, Genetic Predisposition to Disease, Genetic Variation, Genome-Wide Association Study, Humans, Infant, Infant, Newborn, Maternal Exposure adverse effects, Pregnancy, Prenatal Exposure Delayed Effects, Quantitative Trait Loci, Smoking adverse effects, Child Development, DNA Methylation, Epigenesis, Genetic, Epigenomics methods
Abstract: Background: DNA methylation has been found to associate with disease, aging and environmental exposure, but it is unknown how genome, environment and disease influence DNA methylation dynamics in childhood., Results: By analysing 538 paired DNA blood samples from children at birth and at 4-5 years old and 726 paired samples from children at 4 and 8 years old from four European birth cohorts using the Illumina Infinium Human Methylation 450 k chip, we have identified 14,150 consistent age-differential methylation sites (a-DMSs) at epigenome-wide significance of p < 1.14 × 10 -7 . Genes with an increase in age-differential methylation were enriched in pathways related to 'development', and were more often located in bivalent transcription start site (TSS) regions, which can silence or activate expression of developmental genes. Genes with a decrease in age-differential methylation were involved in cell signalling, and enriched on H3K27ac, which can predict developmental state. Maternal smoking tended to decrease methylation levels at the identified da-DMSs. We also found 101 a-DMSs (0.71%) that were regulated by genetic variants using cis-differential Methylation Quantitative Trait Locus (cis-dMeQTL) mapping. Moreover, a-DMS-associated genes during early development were significantly more likely to be linked with disease., Conclusion: Our study provides new insights into the dynamic epigenetic landscape of the first 8 years of life.
Published: 2017
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20. DNA methylation loci associated with atopy and high serum IgE: a genome-wide application of recursive Random Forest feature selection.

Author: Everson TM, Lyons G, Zhang H, Soto-Ramírez N, Lockett GA, Patil VK, Merid SK, Söderhäll C, Melén E, Holloway JW, Arshad SH, and Karmaus W
Subjects: Adolescent, Cohort Studies, CpG Islands, Female, Genetic Loci, Genome, Human, Humans, Hypersensitivity, Immediate diagnosis, Hypersensitivity, Immediate epidemiology, Male, Prevalence, Skin Tests, United Kingdom epidemiology, DNA Methylation, Hypersensitivity, Immediate blood, Hypersensitivity, Immediate genetics, Immunoglobulin E blood
Abstract: Background: The prevalence of allergic diseases are increasing worldwide, emphasizing the need to elucidate their pathogeneses. The aims of this study were to use a two-stage design to identify DNA methylation levels at cytosine-phosphate-guanine (CpG) sites across the genome associated with atopy and high serum immunoglobulin E (IgE), then to replicate our findings in an independent cohort., Methods: Atopy was assessed via skin prick tests and high serum IgE. Methylation levels were measured from whole blood using the Illumina Infinium HumanMethylation450 BeadChip from 18-year-old women (n = 245) and men (n = 122) in the Isle of Wight birth cohort. After data cleaning and processing, and removing probes with possible single nucleotide polymorphisms, DNA methylation levels from 254,460 CpG sites from the 245 women were subjected to recursive Random Forest feature selection for stage 1. The sites selected from stage 1 were tested in stage 2 for associations with atopy and high IgE levels (>200 kU/L) via logistic regression adjusted for predicted cell-type proportions and sex. Sites significantly associated with atopy in stage 2 underwent replication tests in the independent Swedish birth cohort BAMSE (n = 464)., Results: In stage 1, 62 sites were selected, of which 22 were associated with atopy in stage 2 (P-value range 6.5E-9 to 1.4E-5) and 12 associated with high IgE levels (P-value range 1.1E-5 to 7.1E-4) at the Bonferroni adjusted alpha (0.05/62 = 0.0008). Of the 19 available sites, 13 were replicated., Conclusions: We identified 13 novel epigenetic loci associated with atopy and high IgE that could serve as candidate loci for future studies; four were within genes with known roles in the immune response (cg04983687 in the body of ZFPM1, cg18219873 in the 5'UTR of PRG2, cg27469152 in the 3'UTR of EPX, and cg09332506 in the body of COPA).
Published: 2015
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20 results on '"Melén, E."'

1. Optimizing care for children with difficult-to-treat and severe asthma through specialist paediatric asthma centres: expert practical experience and advice

2. ARIA 2016: Care pathways implementing emerging technologies for predictive medicine in rhinitis and asthma across the life cycle

3. Erratum to : Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3: Area 5)

4. Erratum to: Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3: Area 5).

5. Erratum to: Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3: Area 5)

6. Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3 Area 5)

7. ARIA 2016 : Care pathways implementing emerging technologies for predictive medicine in rhinitis and asthma across the life cycle

8. Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3 Area 5)

9. Genes associated with polymorphic variants predicting lung function are differentially expressed during human lung development.

10. BMI trajectories from birth to young adulthood associate with distinct cardiometabolic profiles.

11. Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude.

12. Changes in lifestyle, adiposity, and cardiometabolic markers among young adults in Sweden during the COVID-19 pandemic.

13. Health-related quality of life decreases in young people with asthma during the transition from adolescence to young adulthood: a birth cohort study.

14. DNA methylation and aeroallergen sensitization: The chicken or the egg?

15. Immunoprofiling of active and inactive systemic juvenile idiopathic arthritis reveals distinct biomarkers: a single-center study.

16. DNA methylation and body mass index from birth to adolescence: meta-analyses of epigenome-wide association studies.

17. Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age.

18. Lung function development after preterm birth in relation to severity of Bronchopulmonary dysplasia.

19. The emerging landscape of dynamic DNA methylation in early childhood.

20. DNA methylation loci associated with atopy and high serum IgE: a genome-wide application of recursive Random Forest feature selection.

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