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3 results on '"Meun, Cindy"'

1. Cardiovascular RiskprofilE - IMaging and gender-specific disOrders (CREw-IMAGO) : Rationale and design of a multicenter cohort study

Author

Zoet, Gerbrand A., Meun, Cindy, Benschop, Laura, Boersma, Eric, Budde, Ricardo P.J., Fauser, Bart C.J.M., de Groot, Christianne J. M., van der Lugt, Aad, Maas, Angela H E M, Moons, Karl G.M., Roeters Van Lennep, Jeanine E., Roos-Hesselink, Jolien W, Steegers, Eric A. P., van Rijn, Bas B., Laven, Joop S E, Franx, Arie, Velthuis, Birgitta K., Zoet, Gerbrand A., Meun, Cindy, Benschop, Laura, Boersma, Eric, Budde, Ricardo P.J., Fauser, Bart C.J.M., de Groot, Christianne J. M., van der Lugt, Aad, Maas, Angela H E M, Moons, Karl G.M., Roeters Van Lennep, Jeanine E., Roos-Hesselink, Jolien W, Steegers, Eric A. P., van Rijn, Bas B., Laven, Joop S E, Franx, Arie, and Velthuis, Birgitta K.

Published
2017

2. Cardiovascular RiskprofilE - IMaging and gender-specific disOrders (CREw-IMAGO): Rationale and design of a multicenter cohort study

Author

UMC Utrecht, MS Verloskunde, Circulatory Health, MS Radiologie, MS VPG/Gynaecologie, Brain, Child Health, Epi Methoden, Cancer, JC onderzoeksprogramma Methodologie, DV&B-MT-Medisch, Researchgr. Hart-brein as., Zoet, Gerbrand A., Meun, Cindy, Benschop, Laura, Boersma, Eric, Budde, Ricardo P.J., Fauser, Bart C.J.M., de Groot, Christianne J. M., van der Lugt, Aad, Maas, Angela H E M, Moons, Karl G.M., Roeters Van Lennep, Jeanine E., Roos-Hesselink, Jolien W, Steegers, Eric A. P., van Rijn, Bas B., Laven, Joop S E, Franx, Arie, Velthuis, Birgitta K., UMC Utrecht, MS Verloskunde, Circulatory Health, MS Radiologie, MS VPG/Gynaecologie, Brain, Child Health, Epi Methoden, Cancer, JC onderzoeksprogramma Methodologie, DV&B-MT-Medisch, Researchgr. Hart-brein as., Zoet, Gerbrand A., Meun, Cindy, Benschop, Laura, Boersma, Eric, Budde, Ricardo P.J., Fauser, Bart C.J.M., de Groot, Christianne J. M., van der Lugt, Aad, Maas, Angela H E M, Moons, Karl G.M., Roeters Van Lennep, Jeanine E., Roos-Hesselink, Jolien W, Steegers, Eric A. P., van Rijn, Bas B., Laven, Joop S E, Franx, Arie, and Velthuis, Birgitta K.

Published
2017

3. Cardiovascular RiskprofilE - IMaging and gender-specific disOrders (CREw-IMAGO): rationale and design of a multicenter cohort study.

Author

Zoet GA, Meun C, Benschop L, Boersma E, Budde RPJ, Fauser BCJM, de Groot CJM, van der Lugt A, Maas AHEM, Moons KGM, Roeters van Lennep JE, Roos-Hesselink JW, Steegers EAP, van Rijn BB, Laven JSE, Franx A, and Velthuis BK

Subjects
Coronary Angiography, Female, Humans, Hypertension, Pregnancy-Induced physiopathology, Middle Aged, Netherlands, Polycystic Ovary Syndrome complications, Primary Ovarian Insufficiency complications, Prognosis, Prospective Studies, Pulse Wave Analysis methods, Risk Factors, Tomography, X-Ray Computed, Cardiovascular Diseases diagnostic imaging, Cardiovascular Diseases physiopathology
Abstract

Background: Reproductive disorders, such as polycystic ovary syndrome (PCOS), primary ovarian insufficiency (POI) and hypertensive pregnancy disorders (HPD) like pre-eclampsia (PE), are associated with an increased risk of cardiovascular disease (CVD). Detection of early signs of cardiovascular disease (CVD), as well as identification of risk factors among women of reproductive age which improve cardiovascular risk prediction, is a challenge and current models might underestimate long-term health risks. The aim of this study is to assess cardiovascular disease in patients with a history of a reproductive disorder by low-dose computed tomography (CT)., Methods: Women of 45 - 55 years, who experienced a reproductive disorder (PCOS, POI, HPD), are invited to participate in this multicenter, prospective, cohort study. Women will be recruited after regular cardiovascular screening, including assessment of classical cardiovascular risk factors. CT of the coronary arteries (both coronary artery calcium scoring (CACS), and contrast-enhanced coronary CT angiography (CCTA)) and carotid siphon calcium scoring (CSC) is planned in 300 women with HPD and 300 women with PCOS or POI. In addition, arterial stiffness (non-invasive pulse wave velocity (PWV)) measurement and cell-based biomarkers (inflammatory circulating cells) will be obtained., Discussion: Initial inclusion is focused on women of 45 - 55 years. However, the age range (40 - 45 years and/or ≥ 55 years) and group composition may be adjusted based on the findings of the interim analysis. Participants can potentially benefit from information obtained in this study concerning their current cardiovascular health and expected future risk of cardiovascular events. The results of this study will provide insights in the development of CVD in women with a history of reproductive disorders. Ultimately, this study may lead to improved cardiovascular prediction models and will provide an opportunity for timely adjustment of preventive strategies. Limitations of this study include the possibility of overdiagnosis and the average radiation dose of 3.5 mSv during coronary and carotid siphon CT, although the increased lifetime malignancy risk is negligible., Trial Registration: Netherlands Trial Register, NTR5531 . Date registered: October 21st, 2015.

Published
2017
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