9 results on '"Mieno, Makiko"'
Search Results
2. Association of CYP2A6 gene deletion with cancers in Japanese elderly: an autopsy study
- Author
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Abudushataer, Maidina, Sato, Noriko, Mieno, Makiko, Sawabe, Motoji, Muramatsu, Masaaki, and Arai, Tomio
- Published
- 2020
- Full Text
- View/download PDF
3. Trends of kidney transplantation in Japan in 2018: data from the kidney transplant registry
- Author
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Yagisawa, Takashi, Mieno, Makiko, Ichimaru, Naotsugu, Morita, Ken, Nakamura, Michio, Hotta, Kiyohiko, Kenmochi, Takashi, and Yuzawa, Kenji
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- 2019
- Full Text
- View/download PDF
4. Ramen restaurant prevalence is associated with stroke mortality in Japan: an ecological study
- Author
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Matsuzono, Kosuke, Mieno, Makiko, and Fujimoto, Shigeru
- Published
- 2019
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5. Association of the RYR3 gene polymorphisms with atherosclerosis in elderly Japanese population.
- Author
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Chenxi Zhao, Ikeda, Shinobu, Arai, Tomio, Naka-Mieno, Makiko, Sato, Noriko, Muramatsu, Masaaki, and Sawabe, Motoji
- Subjects
ATHEROSCLEROSIS ,RYANODINE receptors ,SINGLE nucleotide polymorphisms ,GENETIC polymorphisms ,CAROTID artery - Abstract
Background The Ryanodine receptor 3 gene (RYR3) encodes an intracellular calcium channel that mediates the efflux of Ca
2+ from intracellular stores. Two single-nucleotide polymorphisms (SNPs) in the RYR3 gene have been shown to associate with stroke (rs877087) and carotid intima-media thickness (rs2229116) in two independent genome-wide association studies (GWAS) in Caucasian. We investigated the effect of these two SNPs as well as the 31.1 kilobases spanning region on atherosclerosis in Japanese population. Methods Atherosclerotic severity was assessed by carotid artery (n = 1374) and pathological atherosclerosis index (PAI) (n = 1262), which is a macroscopic examination of the luminal surfaces of 8 systemic arteries in consecutive autopsy samples. 4 tag SNPs in the 31.1 Kb region, rs877087, rs2132207, rs658750 and rs2229116, were genotyped and haplotypes were inferred to study the association with atherosclerotic indices. Results rs877087 and rs2229116 were associated with PAI (OR = 2.07[1.04-4.12] (95%CI), p = 0.038; and OR = 1.38[1.02-1.86], p = 0.035, respectively). rs2229116 was also associated with common carotid atherosclerosis (OR = 1.45 [1.13-1.86], p = 0.003). The risk allele of rs2229116 was opposite from the original report. The haplotype block of this 31.1 Kb region was different between Caucasian and Japanese. Haplotype analysis revealed that only TAGG haplotype was associated with PAI (OR = 0.67[0.48-0.94], p = 0.020) and atherosclerosis of common carotid artery (OR = 0.75[0.58-0.98], p = 0.034). Conclusion rs877087 and rs2229116 of RYR3 gene are associated with atherosclerosis severity in Japanese. The functional difference caused by rs2229116 needs to be investigated. [ABSTRACT FROM AUTHOR]- Published
- 2014
- Full Text
- View/download PDF
6. Alternative statistical methods for estimating efficacy of interferon beta-1b for multiple sclerosis clinical trials.
- Author
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Mieno, Makiko N., Yamaguchi, Takuhiro, and Ohashi, Yasuo
- Subjects
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MULTIPLE sclerosis , *INTERFERONS , *REGRESSION analysis , *CLINICAL trials , *ANTIVIRAL agents - Abstract
Background: In the randomized study of interferon beta-1b (IFN beta-1b) for multiple sclerosis (MS), it has usually been evaluated the simple annual relapse rate as the study endpoint. This study aimed to investigate the performance of various regression models using information regarding the time to each recurrent event and considering the MS specific data generation process, and to estimate the treatment effect of a MS clinical trial data. Methods: We conducted a simulation study with consideration of the pathological characteristics of MS, and applied alternative efficacy estimation methods to real clinical trial data, including 5 extended Cox regression models for time-to-event analysis, a Poisson regression model and a Poisson regression model with Generalized Estimating Equations (GEE). We adjusted for other important covariates that may have affected the outcome. Results: We compared the simulation results for each model. The hazard ratios of real data were estimated for each model including the effects of other covariates. The results (hazard ratios of high-dose to low-dose) of all models were approximately 0.7 (range, 0.613 - 0.769), whereas the annual relapse rate ratio was 0.714. Conclusions: The precision of the treatment estimation was increased by application of the alternative models. This suggests that the use of alternative models that include recurrence event data may provide better analyses. [ABSTRACT FROM AUTHOR]
- Published
- 2011
- Full Text
- View/download PDF
7. Association of the RYR3 gene polymorphisms with atherosclerosis in elderly Japanese population.
- Author
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Zhao, Chenxi, Ikeda, Shinobu, Arai, Tomio, Naka-Mieno, Makiko, Sato, Noriko, Muramatsu, Masaaki, and Sawabe, Motoji
- Abstract
Background: The Ryanodine receptor 3 gene (RYR3) encodes an intracellular calcium channel that mediates the efflux of Ca2+ from intracellular stores. Two single-nucleotide polymorphisms (SNPs) in the RYR3 gene have been shown to associate with stroke (rs877087) and carotid intima-media thickness (rs2229116) in two independent genome-wide association studies (GWAS) in Caucasian. We investigated the effect of these two SNPs as well as the 31.1 kilobases spanning region on atherosclerosis in Japanese population.Methods: Atherosclerotic severity was assessed by carotid artery (n = 1374) and pathological atherosclerosis index (PAI) (n = 1262), which is a macroscopic examination of the luminal surfaces of 8 systemic arteries in consecutive autopsy samples. 4 tag SNPs in the 31.1 Kb region, rs877087, rs2132207, rs658750 and rs2229116, were genotyped and haplotypes were inferred to study the association with atherosclerotic indices.Results: rs877087 and rs2229116 were associated with PAI (OR = 2.07 [1.04-4.12] (95% CI), p = 0.038; and OR = 1.38 [1.02-1.86], p = 0.035, respectively). rs2229116 was also associated with common carotid atherosclerosis (OR = 1.45 [1.13-1.86], p = 0.003). The risk allele of rs2229116 was opposite from the original report. The haplotype block of this 31.1 Kb region was different between Caucasian and Japanese. Haplotype analysis revealed that only TAGG haplotype was associated with PAI (OR = 0.67 [0.48-0.94], p = 0.020) and atherosclerosis of common carotid artery (OR = 0.75 [0.58-0.98], p = 0.034).Conclusion: rs877087 and rs2229116 of RYR3 gene are associated with atherosclerosis severity in Japanese. The functional difference caused by rs2229116 needs to be investigated. [ABSTRACT FROM AUTHOR]- Published
- 2014
- Full Text
- View/download PDF
8. Dose-dependent effect of daptomycin on the artificial prolongation of prothrombin time in coagulation abnormalities: in vitro verification.
- Author
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Hashimoto H, Saito M, Kanda N, Yamamoto T, Mieno M, and Hatakeyama S
- Subjects
- Anticoagulants therapeutic use, Blood Coagulation Disorders drug therapy, Dose-Response Relationship, Drug, Humans, International Normalized Ratio, Liver Cirrhosis drug therapy, Warfarin therapeutic use, Anti-Bacterial Agents pharmacology, Blood Coagulation Disorders blood, Daptomycin pharmacology, Liver Cirrhosis blood, Prothrombin Time
- Abstract
Background: Several studies have reported that daptomycin induced artificial prolongation of prothrombin time (PT) in some test reagents, particularly in warfarin users. However, it remains unknown whether the artificial prolongation can be affected by coagulation abnormalities other than the use of warfarin. Thus, we investigated the effect of daptomycin on PT with two types of coagulation abnormalities., Methods: Plasma samples were pooled by four groups: healthy volunteers (Plasma A), warfarin users with a PT-international normalized ratio (INR) of approximately 2.0 (Plasma B) or 3.0 (Plasma C), and patients with liver cirrhosis with a PT-INR of approximately 2.0 (Plasma D). Plasma A was composed of plasma from two healthy individuals (9 mL from each individual). Plasma B, C, and D were composed of plasma from 36 patients (0.5 mL from each patient). Daptomycin was added to each sample to create solutions with several concentrations (0-150 μg/mL). The PT-INR for each solution was measured with three PT reagents. Linear regression analyses were used to determine the association between daptomycin concentration and PT-INR. The relative change in PT-INR due to daptomycin concentrations was calculated., Results: Strong linear correlations were observed between daptomycin concentrations and PT-INR for all the plasma groups and reagents (R
2 > 0.7, P < 0.01). At a daptomycin concentration of 150 μg/mL, the relative increase of PT-INR was ≥10% in the majority of the plasma groups with an elevated baseline PT-INR in all reagents tested., Conclusions: Daptomycin induced the artificial prolongation of PT-INR in a concentration-dependent manner, particularly in plasma samples with an elevated baseline PT-INR. PT should be evaluated at the trough levels of daptomycin.- Published
- 2017
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9. Associations between the orexin (hypocretin) receptor 2 gene polymorphism Val308Ile and nicotine dependence in genome-wide and subsequent association studies.
- Author
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Nishizawa D, Kasai S, Hasegawa J, Sato N, Yamada H, Tanioka F, Nagashima M, Katoh R, Satoh Y, Tagami M, Ujike H, Ozaki N, Inada T, Iwata N, Sora I, Iyo M, Yamada M, Kondo N, Won MJ, Naruse N, Uehara-Aoyama K, Itokawa M, Ohi K, Hashimoto R, Tanisawa K, Arai T, Mori S, Sawabe M, Naka-Mieno M, Yamada Y, Yamada M, Sato N, Muramatsu M, Tanaka M, Irukayama-Tomobe Y, Saito YC, Sakurai T, Hayashida M, Sugimura H, and Ikeda K
- Subjects
- Abdomen surgery, Adolescent, Adult, Aged, Aged, 80 and over, Asian People genetics, Autopsy, Female, Genetic Loci, Goiter genetics, Humans, Male, Methamphetamine, Middle Aged, Pain, Postoperative etiology, Pain, Postoperative genetics, Physical Chromosome Mapping, Reproducibility of Results, Schizotypal Personality Disorder genetics, Young Adult, Genetic Predisposition to Disease, Genome-Wide Association Study, Orexin Receptors genetics, Polymorphism, Single Nucleotide genetics, Tobacco Use Disorder genetics
- Abstract
Background: Many genetic and environmental factors are involved in the etiology of nicotine dependence. Although several candidate gene variations have been reported by candidate gene studies or genome-wide association studies (GWASs) to be associated with smoking behavior and the vulnerability to nicotine dependence, such studies have been mostly conducted with subjects with European ancestry. However, genetic factors have rarely been investigated for the Japanese population as GWASs. To elucidate genetic factors involved in nicotine dependence in Japanese, the present study comprehensively explored genetic contributors to nicotine dependence by using whole-genome genotyping arrays with more than 200,000 markers in Japanese subjects., Results: The subjects for the GWAS and replication study were 148 and 374 patients, respectively. A two-stage GWAS was conducted using the Fagerström Test for Nicotine Dependence (FTND), Tobacco Dependence Screener (TDS), and number of cigarettes smoked per day (CPD) as indices of nicotine dependence. For the additional association analyses, patients who underwent major abdominal surgery, patients with methamphetamine dependence/psychosis, and healthy subjects with schizotypal personality trait data were recruited. Autopsy specimens with various diseases were also evaluated. After the study of associations between more than 200,000 marker single-nucleotide polymorphisms (SNPs) and the FTND, TDS, and CPD, the nonsynonymous rs2653349 SNP (located on the gene that encodes orexin [hypocretin] receptor 2) was selected as the most notable SNP associated with FTND, with a p value of 0.0005921 in the two-stage GWAS. This possible association was replicated for the remaining 374 samples. This SNP was also associated with postoperative pain, the initiation of methamphetamine use, schizotypal personality traits, and susceptibility to goiter., Conclusions: Although the p value did not reach a conventional genome-wide level of significance in our two-stage GWAS, we obtained significant results in the subsequent analyses that suggest that the rs2653349 SNP (Val308Ile) could be a genetic factor that is related to nicotine dependence and possibly pain, schizotypal personality traits, and goiter in the Japanese population.
- Published
- 2015
- Full Text
- View/download PDF
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