1. Genetic Structure of the Spanish Population.
- Author
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Gayán, Javier, Galan, José J., González-Pérez, Antonio, Sáez, María Eugenia, Martínez-Larrad, María Teresa, Zabena, Carina, Rivero, M. Carmen, Salinas, Ana, Ramírez-Lorca, Reposo, Morón, Francisco J., Royo, Jose Luis, Moreno-Rey, Concha, Velasco, Juan, Carrasco, José M., Molero, Eva, Ochoa, Carolina, Ochoa, María Dolores, Gutiérrez, Marta, Reina, Mercedes, and Pascual, Rocío
- Subjects
HUMAN population genetics ,BIOLOGICAL variation ,LINKAGE disequilibrium ,POPULATION research - Abstract
Background: Genetic admixture is a common caveat for genetic association analysis. Therefore, it is important to characterize the genetic structure of the population under study to control for this kind of potential bias. Results: In this study we have sampled over 800 unrelated individuals from the population of Spain, and have genotyped them with a genome-wide coverage. We have carried out linkage disequilibrium, haplotype, population structure and copy-number variation (CNV) analyses, and have compared these estimates of the Spanish population with existing data from similar efforts. Conclusions: In general, the Spanish population is similar to the Western and Northern Europeans, but has a more diverse haplotypic structure. Moreover, the Spanish population is also largely homogeneous within itself, although patterns of micro-structure may be able to predict locations of origin from distant regions. Finally, we also present the first characterization of a CNV map of the Spanish population. These results and original data are made available to the scientific community. [ABSTRACT FROM AUTHOR]
- Published
- 2010
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