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Your search keyword '"Payvandi, Faribourz"' showing total 2 results
Start Over Author "Payvandi, Faribourz" Publisher biomed central
2 results on '"Payvandi, Faribourz"'

1. A novel technique for quantifying changes in vascular density, endothelial cell proliferation and protein expression in response to modulators of angiogenesis using the chick chorioallantoic membrane (CAM) assay

Author

Kohn Elise, Knezevic Vladimir, Lorang Dominique, Baibakov Galina, Vu Huan, He Mei, O'Connor Sarah, Patton Angela, Kayton Mark L, Miller Walter J, Alexander H Richard, Stirling David, Payvandi Faribourz, Muller George W, and Libutti Steven K

Subjects
Confocal microscopy, Research, Layered Expression Scanning (LES), lcsh:R, XTT assay, lcsh:Medicine, sense organs, Angiogenesis, skin and connective tissue diseases, Chorioallantoic membrane (CAM)
Abstract

Reliable quantitative evaluation of molecular pathways is critical for both drug discovery and treatment monitoring. We have modified the CAM assay to quantitatively measure vascular density, endothelial proliferation, and changes in protein expression in response to anti-angiogenic and pro-angiogenic agents. This improved CAM assay can correlate changes in vascular density with changes seen on a molecular level. We expect that these described modifications will result in a single in vivo assay system, which will improve the ability to investigate molecular mechanisms underlying the angiogenic response.

Published
2004

2. A novel technique for quantifying changes in vascular density, endothelial cell proliferation and protein expression in response to modulators of angiogenesis using the chick chorioallantoic membrane (CAM) assay.

Author

Miller, Walter J., Kayton, Mark L., Patton, Angela, O'Connor, Sarah, Mei He, Huan Vu, Baibakov, Galina, Lorang, Dominique, Knezevic, Vladimir, Kohn, Elise, Alexander, H. Richard, Stirling, David, Payvandi, Faribourz, Muller, George W., and Libutti, Steven K.

Subjects
NEOVASCULARIZATION, GENE expression, CELL proliferation, CELL growth, QUANTITATIVE research
Abstract

Reliable quantitative evaluation of molecular pathways is critical for both drug discovery and treatment monitoring. We have modified the CAM assay to quantitatively measure vascular density, endothelial proliferation, and changes in protein expression in response to anti-angiogenic and pro-angiogenic agents. This improved CAM assay can correlate changes in vascular density with changes seen on a molecular level. We expect that these described modifications will result in a single in vivo assay system, which will improve the ability to investigate molecular mechanisms underlying the angiogenic response. [ABSTRACT FROM AUTHOR]

Published
2004
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