1. Early Neospora caninum infection dynamics in cattle after inoculation at mid-gestation with high (Nc-Spain7)- or low (Nc-Spain1H)-virulence isolates.
- Author
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Jiménez-Pelayo L, García-Sánchez M, Vázquez P, Regidor-Cerrillo J, Horcajo P, Collantes-Fernández E, Blanco-Murcia J, Gutiérrez-Expósito D, Román-Trufero A, Osoro K, Benavides J, and Ortega-Mora LM
- Subjects
- Animals, Cattle, Cattle Diseases parasitology, Coccidiosis immunology, Coccidiosis parasitology, Female, Gestational Age, Neospora physiology, Pregnancy, Pregnancy Complications, Parasitic immunology, Pregnancy Complications, Parasitic parasitology, Vaccination veterinary, Virulence genetics, Cattle Diseases immunology, Coccidiosis veterinary, Fetus parasitology, Neospora pathogenicity, Placenta parasitology, Pregnancy Complications, Parasitic veterinary
- Abstract
Early Neospora caninum infection dynamics were investigated in pregnant heifers intravenously inoculated with PBS (G-Control) or 10
7 tachyzoites of high (G-NcSpain7)- or low (G-NcSpain1H)-virulence isolates at 110 days of gestation. Serial culling at 10 and 20 days post-infection (dpi) was performed. Fever was detected at 1 dpi in both infected groups (P < 0.0001), and a second peak was detected at 3 dpi only in G-NcSpain7 (P < 0.0001). At 10 dpi, Nc-Spain7 was detected in placental samples from one animal related to focal necrosis, and Nc-Spain7 transmission was observed, although no foetal lesions were associated with this finding. The presence of Nc-Spain1H in the placenta or foetuses, as well as lesions, were not detected at 10 dpi. At 20 dpi, G-NcSpain7 animals showed almost 100% positive placental tissues and severe focal necrosis as well as 100% transmission. Remarkably, foetal mortality was detected in two G-NcSpain7 heifers. Only one animal from G-NcSpain1H presented positive placental samples. No foetal mortality was detected, and lesions and parasite transmission to the foetus were not observed in this group. Finally, 100% of G-NcSpain7 heifers at 20 dpi presented specific antibodies, while only 60% of G-NcSpain1H animals presented specific antibodies at 20 dpi. In addition, earlier seroconversion in G-Nc-Spain7 was observed. In conclusion, tachyzoites from Nc-Spain7 reached the placenta earlier and multiplied, leading to lesion development, transmission to the foetus and foetal mortality, whereas Nc-Spain1H showed delayed infection of the placenta and no lesional development or transmission during early infection. more...- Published
- 2019
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