1. The impact of cardiomotor rehabilitation on endothelial function in elderly patients with chronic heart failure
- Author
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Yachun Wang, Xiaoxi Wang, Juming Chen, Qingfeng Feng, Wangyuan Zeng, Yanling Song, Xinbo Ji, and Shenhong Gu
- Subjects
Cardiac function curve ,Male ,Vascular Endothelial Growth Factor A ,medicine.medical_specialty ,Nitric Oxide Synthase Type III ,Angiogenesis ,Class I Phosphatidylinositol 3-Kinases ,medicine.medical_treatment ,Enos ,Internal medicine ,Natriuretic Peptide, Brain ,medicine ,Diseases of the circulatory (Cardiovascular) system ,Humans ,RNA, Messenger ,Endothelial progenitor cells ,Angiology ,Aged ,Heart Failure ,PI3K/AKT ,Rehabilitation ,Ejection fraction ,Cardiac Rehabilitation ,biology ,business.industry ,Research ,Stroke Volume ,medicine.disease ,biology.organism_classification ,Chronic heart failure ,Cardiac surgery ,Exercise Therapy ,Exercise rehabilitation ,Heart failure ,RC666-701 ,Cardiology ,Female ,Endothelium, Vascular ,Cardiology and Cardiovascular Medicine ,business ,Proto-Oncogene Proteins c-akt ,Signal Transduction - Abstract
Background To explore the effects of cardiac exercise rehabilitation on peripheral blood endothelial progenitor cells (EPC) in elderly patients with chronic heart failure. Methods 80 elderly patients with chronic heart failure were selected from March 2017 to March 2019 and randomly divided into two groups (N = 40). The control group was treated routinely and walked freely for 30–60 min every day. The patients in the exercise rehabilitation group developed a cardiac exercise rehabilitation plan. Then, cardiac function and peripheral blood B-natriuretic peptide (BNP) levels in the two groups were compared. The cell viability, proliferation, apoptosis, and invasion ability of EPCs were detected. The levels of the PI3K/AKT pathway and eNOS and VEGF were compared. Results There were no significant differences in all indexes between the two groups before treatment (P > 0.05), and both improved significantly after treatment (P P P P P Conclusions Visceral exercise rehabilitation can improve cardiac ejection and myocardial function in elderly patients with chronic heart failure, and can promote the vitality, proliferation, and invasion of peripheral blood EPC, and promote the expression of eNOS and VEGF by upregulating the PI3K/AKT pathway to promote angiogenesis and endothelial function.
- Published
- 2021