1. Randomized, multicenter study: on-demand versus continuous maintenance treatment with esomeprazole in patients with non-erosive gastroesophageal reflux disease
- Author
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Ekkehard Bayerdörffer, Lars-Erik Svedberg, Luis Rodrigo, Fermín Mearin, Marc-Andre Bigard, Nanna Keeling, Tore Persson, Werner Weiss, Hennie Grundling, Juan Enrique Dominguez Muñoz, and Stefan Eklund
- Subjects
Adult ,Male ,medicine.medical_specialty ,On-demand ,Nerd ,Discontinuation ,Gastroesophageal reflux disease ,Gastroenterology ,Drug Administration Schedule ,Esomeprazole ,Maintenance Chemotherapy ,03 medical and health sciences ,0302 clinical medicine ,Maintenance therapy ,Heartburn ,Internal medicine ,medicine ,Humans ,Non-erosive reflux disease ,Reflux esophagitis ,Esophagitis, Peptic ,business.industry ,Reflux ,Proton Pump Inhibitors ,General Medicine ,Middle Aged ,Confidence interval ,Treatment Outcome ,Patient Satisfaction ,030220 oncology & carcinogenesis ,Gastroesophageal Reflux ,030211 gastroenterology & hepatology ,Female ,medicine.symptom ,business ,medicine.drug ,Research Article - Abstract
Most patients with gastroesophageal reflux disease experience symptomatic relapse after stopping acid-suppressive medication. The aim of this study was to compare willingness to continue treatment with esomeprazole on-demand versus continuous maintenance therapy for symptom control in patients with non-erosive reflux disease (NERD) after 6 months. This multicenter, open-label, randomized, parallel-group study enrolled adults with NERD who were heartburn-free after 4 weeks’ treatment with esomeprazole 20 mg daily. Patients received esomeprazole 20 mg daily continuously or on-demand for 6 months. The primary variable was discontinuation due to unsatisfactory treatment. On-demand treatment was considered non-inferior if the upper limit of the one-sided 95 % confidence interval (CI) for the difference between treatments was
- Published
- 2016