3 results on '"Sun, Jian‐Hua"'
Search Results
2. Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy with lobaplatin and docetaxel improves survival for patients with peritoneal carcinomatosis from abdominal and pelvic malignancies.
- Author
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Wu HT, Yang XJ, Huang CQ, Sun JH, Ji ZH, Peng KW, Zhang Q, and Li Y
- Subjects
- Antineoplastic Agents administration & dosage, Antineoplastic Agents therapeutic use, Antineoplastic Combined Chemotherapy Protocols administration & dosage, Carcinoma mortality, Carcinoma secondary, Chemotherapy, Adjuvant adverse effects, Chemotherapy, Cancer, Regional Perfusion instrumentation, Chemotherapy, Cancer, Regional Perfusion methods, Cyclobutanes administration & dosage, Cyclobutanes pharmacology, Cyclobutanes therapeutic use, Docetaxel, Drug Synergism, Feasibility Studies, Female, Humans, Male, Middle Aged, Organoplatinum Compounds administration & dosage, Organoplatinum Compounds pharmacology, Organoplatinum Compounds therapeutic use, Peritoneal Neoplasms mortality, Peritoneal Neoplasms secondary, Survival Rate, Taxoids administration & dosage, Taxoids pharmacology, Taxoids therapeutic use, Treatment Outcome, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Carcinoma therapy, Cytoreduction Surgical Procedures adverse effects, Gastrointestinal Neoplasms pathology, Genital Neoplasms, Female pathology, Hyperthermia, Induced, Peritoneal Neoplasms therapy
- Abstract
Background: This work was to evaluate the perioperative safety and efficacy of cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) with lobaplatin and docetaxel in patients with peritoneal carcinomatosis (PC) from gastrointestinal and gynecological cancers., Methods: Patients were treated by CRS + HIPEC with lobaplatin 50 mg/m(2) and docetaxel 60 mg/m(2) in 6000 mL of normal saline at 43 ± 0.5 °C for 60 min. Vital signs were recorded for 6 days after CRS + HIPEC procedures. Perioperative serious adverse events (SAE), hematological, hepatic, renal, and electrolytes parameters, the changes in serum tumor markers (TM) before and after operation, patient recovery, and overall survival (OS) were analyzed., Results: One hundred consecutive PC patients underwent 105 CRS + HIPEC procedures and postoperative chemotherapy. The median CRS + HIPEC duration was 463 (range, 245-820) min, and the highest temperature and heart rate during six postoperative days were 38.6 °C (median 37.5 °C) and 124 bpm (median 100 bpm), respectively. The 30-day perioperative SAE occurred in 16 (15.2 %) and mortality occurred in 2 (1.9 %) patients. Most routine blood laboratory tests at 1 week after surgery turned normal. Among 82 cases with increased preoperative TM CEA, CA125, and CA199, 71 cases had TM levels reduced or turned normal. Median time to nasogastric tube removal was 5 (range, 3-23) days, to liquid food intake 6 (range, 4-24) days, and to abdominal suture removal 15 (range, 10-30) days. At the median follow-up of 19.7 (range, 7.5-89.2) months, the median OS was 24.2 (95 % CI, 15.0-33.4) months, and the 1-, 3-, and 5-year OS rates were 77.5, 32.5, and 19.8 %, respectively. Univariate analysis identified five independent prognostic factors on OS: the origin of PC, peritoneal cancer index, completeness of CRS, cycles of adjuvant chemotherapy, and SAE., Conclusions: CRS + HIPEC with lobaplatin and docetaxel to treat PC is a feasible procedure with acceptable safety and can prolong the survival in selected patients with PC., Trial Registration: ClinicalTrials.gov, NCT00454519.
- Published
- 2016
- Full Text
- View/download PDF
3. Long-term effect of early postnatal overnutrition on insulin resistance and serum fatty acid profiles in male rats.
- Author
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Bei F, Jia J, Jia YQ, Sun JH, Liang F, Yu ZY, and Cai W
- Subjects
- Adipose Tissue, White metabolism, Animals, Blood Glucose metabolism, Gene Expression Regulation, Glucose Transporter Type 4 blood, Glucose Transporter Type 4 genetics, Humans, Insulin blood, Insulin genetics, Insulin Receptor Substrate Proteins blood, Insulin Receptor Substrate Proteins genetics, Leptin blood, Leptin genetics, Lipoproteins, HDL blood, Litter Size, Male, Obesity blood, Overnutrition blood, Proto-Oncogene Proteins c-akt blood, Proto-Oncogene Proteins c-akt genetics, RNA, Messenger genetics, Rats, Rats, Sprague-Dawley, Signal Transduction, Triglycerides blood, Fatty Acids, Nonesterified blood, Insulin Resistance, Obesity genetics, Overnutrition genetics, RNA, Messenger blood
- Abstract
Background: Increasing evidence suggests that overnutrition during the early postnatal period, a critical window of development, increases the risk of adult-onset obesity and insulin resistance. In this study, we investigated the impact of overnutrition during the suckling period on body weight, serum biochemistry and serum fatty acid metabolomics in male rats., Methods: Rats raised in small litters (SL, 3 pups/dam) and normal litters (NL, 10 pups/dam) were used to model early postnatal overnutrition and control, respectively. Serum glucose, triglyceride, high-density lipoprotein-cholesterol, free fatty acid, insulin and leptin concentrations were assayed using standard biochemical techniques. Serum fatty acids were identified and quantified using a gas chromatography-mass spectrometry-based metabolomic approach. mRNA and protein levels of key components of the insulin receptor signaling pathway were measured in epididymal fat and gastrocnemius muscle by quantitative PCR and western blotting., Results: SL rats were 37.3 % and 15.1 % heavier than NL rats at weaning and 16-weeks-old, respectively. They had increased visceral fat mass, adult-onset insulin resistance and glucose intolerance as well as elevated serum levels of free fatty acids and triglycerides. All detectable fatty acids were elevated in the serum of SL pups at weaning compared to NL controls, and significant increases in the levels of four fatty acids (palmitic acid, palmitoleic acid, oleic acid and arachidonic acid) persisted into adulthood. Moreover, a significantly positive correlation was identified between an insulin resistance index (HOMA-IR) and concentrations of myristic, palmitic, palmitoleic and oleic acid in serum at postnatal 16 weeks. Early postnatal overnutrition also resulted in a significant downregulation of insulin receptor substrate-1 (Irs-1), protein kinase B (Akt2) and glucose transporter 4 (Glut4) at the protein level in epididymal fat of SL rats at 16 weeks, accompanied by decreased mRNA levels for Irs-1 and Glut4. In gastrocnemius muscle, Akt2 and Glut4 mRNA and Glut4 protein levels were significantly decreased in SL rats., Conclusions: This study demonstrates that early postnatal overnutrition can have long-lasting effects on body weight and serum fatty acid profiles and can lead to impaired insulin signaling pathway in visceral white adipose tissue and skeletal muscle, which may play a major role in IR.
- Published
- 2015
- Full Text
- View/download PDF
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