1. Apical polarity in three-dimensional culture systems: where to now?
- Author
-
Inman JL and Bissell MJ
- Subjects
- Animals, Apoptosis physiology, Cell Proliferation, Cell Survival physiology, Cells, Cultured, Epithelial Cells cytology, Epithelium physiology, Humans, Mammary Glands, Animal cytology, Signal Transduction physiology, Tissue Culture Techniques methods, Tissue Engineering, Tissue Scaffolds classification, Cell Differentiation physiology, Cell Polarity physiology, Epithelial Cells physiology, Mammary Glands, Human cytology
- Abstract
Delineation of the mechanisms that establish and maintain the polarity of epithelial tissues is essential to understanding morphogenesis, tissue specificity and cancer. Three-dimensional culture assays provide a useful platform for dissecting these processes but, as discussed in a recent study in BMC Biology on the culture of mammary gland epithelial cells, multiple parameters that influence the model must be taken into account.
- Published
- 2010
- Full Text
- View/download PDF