10 results on '"WANG Xiao-hong"'
Search Results
2. Effect of noninvasive embryo viability testing versus conventional IVF on the live birth rate in IVF/ICSI patients: a study protocol for a double-blind, multicenter, randomized controlled trial
- Author
-
Cheng, Yan-Fei, Zhang, Cui-Lian, Liu, Yun, Ou, Jian-Ping, Chen, Lei, Cai, Gui-Feng, Yang, Zu, Ye, Tian-Min, Wang, Jun, Xie, Juan-Ke, Xiong, Ping, Zhang, Xi-Ya, Li, Min, Xu, Wei-Biao, Wang, Xiao-Qing, Kong, Ling-Yin, Liang, Bo, Wang, Xiao-Hong, Wang, Yue-Qiang, and Yao, Yuan-Qing
- Published
- 2023
- Full Text
- View/download PDF
3. Effect of glycotoxicity and lipotoxicity on carbohydrate antigen 19 − 9 in the patients with diabetes
- Author
-
Liu, Xi-yu and Wang, Xiao-hong
- Published
- 2024
- Full Text
- View/download PDF
4. Sex differences in association between cognitive impairment and clinical correlates in Chinese patients with first-episode drug-naïve schizophrenia
- Author
-
Zhao, Na, Wang, Xiao Hong, Kang, Chuan Yi, Zheng, Yue, Yang, Li Ying, Guan, Tie Feng, Bai, Yun Xia, Wei, Ran, Hinman, Hunter C., and Zhang, Xiang Yang
- Published
- 2021
- Full Text
- View/download PDF
5. Prevalence and characterization of hepatitis B and C virus infections in a needle-sharing population in Northern China.
- Author
-
Xu CJ, Zhang CP, Luo BF, Liu LJ, Wang YZ, Wang XH, He QJ, Zhou SS, Guo WS, Wang JH, Yang RF, Zhang HY, Rao HY, Feng B, and Wei L
- Subjects
- Adult, Aged, China epidemiology, Coinfection, Female, Humans, Male, Middle Aged, Prevalence, Real-Time Polymerase Chain Reaction, Substance-Related Disorders, Young Adult, Hepatitis B epidemiology, Hepatitis C epidemiology, Needle Sharing statistics & numerical data
- Abstract
Background: The epidemiologies of hepatitis C virus (HCV) and hepatitis B virus (HBV) infections in specific populations in certain areas of China are poorly understood. A pilot survey of HCV/HBV infections was carried out in villages in Kuancheng County, Heben Province, where injection of sodium benzoate or amphetamines using shared needles has been a common practice. The aims of this study were to analyze the endemicity and characterize HCV/HBV infections in this population., Methods: Data on demographic characteristics and drug abuse were collected from individuals who signed informed consent forms. Serum HCV antibody (anti-HCV), hepatitis B surface antigen (HBsAg), and hepatitis B core antibody (anti-HBc) were measured in all participants. HCV RNA was measured in samples positive for anti-HCV using real-time polymerase chain reaction., Results: Among 852 participants from 11 villages, 49.9% had used sodium benzoate or amphetamine at least once, by intravenous injection. The overall prevalence of anti-HCV, HCV RNA, anti-HBc, HBsAg, and HCV/HBV co-infection was 37.1%, 26.6%, 67.7%, 10.7%, and 30.0%, respectively. Two-hundred-twenty-three of 227 (98.2%) participants positive for HCV RNA were aged >40 years. Co-infection was related to sex, age, number of injections, and time from first injection. The rate of spontaneous HCV RNA clearance was 28.2% (89/316), and was related to the number of injections, time from first injection, and HBsAg positivity. However, HBsAg was related to the anti-HBc signal/cut-off ratio rather than to the above parameters. Trend tests demonstrated that the prevalence of anti-HCV, HCV RNA, and anti-HBc was related to the number of injections (P < 0.001), while HBsAg prevalence was not (P = 0.347)., Conclusions: The prevalence of HCV and HBV infection is likely to be high among individuals older than 40 years in areas of needle sharing, and one-time screening for HCV infection should be offered to these populations.
- Published
- 2015
- Full Text
- View/download PDF
6. Trihelix transcription factor GT-4 mediates salt tolerance via interaction with TEM2 in Arabidopsis.
- Author
-
Wang XH, Li QT, Chen HW, Zhang WK, Ma B, Chen SY, and Zhang JS
- Subjects
- Arabidopsis genetics, Arabidopsis Proteins metabolism, DNA-Binding Proteins metabolism, Gene Expression Regulation, Plant, Trans-Activators metabolism, Arabidopsis physiology, Arabidopsis Proteins genetics, DNA-Binding Proteins genetics, Salt Tolerance genetics, Sodium Chloride metabolism, Trans-Activators genetics
- Abstract
Background: Trihelix transcription factor family is plant-specific and plays important roles in developmental processes. However, their function in abiotic stress response is largely unclear., Results: We studied one member GT-4 from Arabidopsis in relation to salt stress response. GT-4 expression is induced by salt stress and GT-4 protein is localized in nucleus and cytoplasm. GT-4 acts as a transcriptional activator and its C-terminal end is the activation domain. The protein can bind to the cis-elements GT-3 box, GT-3b box and MRE4. GT-4 confers enhanced salt tolerance in Arabidopsis likely through direct binding to the promoter and activation of Cor15A, in addition to possible regulation of other relevant genes. The gt-4 mutant shows salt sensitivity. TEM2, a member of AP2/ERF family was identified to interact with GT-4 in yeast two-hybrid, BiFC and Co-IP assays. Loss-of-function of TEM2 exerts no significant difference on salt tolerance or Cor15A expression in Arabidopsis. However, double mutant gt-4/tem2 shows greater sensitivity to salt stress and lower transcript level of Cor15A than gt-4 single mutant. GT-4 plus TEM2 can synergistically increase the promoter activity of Cor15A., Conclusions: GT-4 interacts with TEM2 and then co-regulates the salt responsive gene Cor15A to improve salt stress tolerance.
- Published
- 2014
- Full Text
- View/download PDF
7. Quantitative assessment of gait and neurochemical correlation in a classical murine model of Parkinson's disease.
- Author
-
Wang XH, Lu G, Hu X, Tsang KS, Kwong WH, Wu FX, Meng HW, Jiang S, Liu SW, Ng HK, and Poon WS
- Subjects
- 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine adverse effects, Analysis of Variance, Animals, Corpus Striatum pathology, Disease Models, Animal, Exploratory Behavior drug effects, Locomotion drug effects, Locomotion physiology, MPTP Poisoning chemically induced, Male, Mice, Mice, Inbred C57BL, Nerve Degeneration etiology, Psychomotor Performance drug effects, Substantia Nigra drug effects, Time Factors, Corpus Striatum metabolism, Gait Disorders, Neurologic etiology, MPTP Poisoning complications, MPTP Poisoning pathology, Substantia Nigra metabolism, Tyrosine 3-Monooxygenase metabolism
- Abstract
Background: Gait deficits are important clinical symptoms of Parkinson's disease (PD). However, existing behavioral tests for the detection of motor impairments in rodents with systemic dopamine depletion only measure akinesia and dyskinesia, and data focusing on gait are scarce. We evaluated gait changes in the methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced C57BL/6 murine model of PD by using a computer-assisted CatWalk system. Correlations of gait parameters with tyrosine hydroxylase (TH) protein levels in the substantia nigra (SN) were also investigated., Results: The gait readouts, including the walking duration, variation of walking speed, step cycle, duty cycle, stance, initial dual stance, terminal dual stance, three- and four-point supports, and the base of support between hind limbs was noted to increase significantly one week after MPTP injection. In contrast, values of the stride length, cadence, swing speed, and diagonal dual support decreased substantially following MPTP treatment (p < 0.05). All of these changes lasted for three weeks after the last MPTP administration. Except for the stance in the fore limbs and the swing speed in the hind limbs, the gait variability in the PD mice showed a closer correlation with the protein levels of TH in the SN than the walking distances in the conventional open field test. Coordination parameters of the regularity index and step pattern were not affected in mice treated with MPTP., Conclusion: Data of the study suggest that the computer-assisted CatWalk system can provide reliable and objective criteria to stratify gait changes arising from MPTP-induced bilateral lesions in C57/BL6 mice. The extent of gait changes was noted to correlate with the expression of the biomarker for dopaminergic neurons. This novel analytical method may hold promise in the study of disease progression and new drug screening in a murine PD model.
- Published
- 2012
- Full Text
- View/download PDF
8. Presence of S100A9-positive inflammatory cells in cancer tissues correlates with an early stage cancer and a better prognosis in patients with gastric cancer.
- Author
-
Fan B, Zhang LH, Jia YN, Zhong XY, Liu YQ, Cheng XJ, Wang XH, Xing XF, Hu Y, Li YA, Du H, Zhao W, Niu ZJ, Lu AP, Li JY, and Ji JF
- Subjects
- Adult, Aged, Aged, 80 and over, Calgranulin A immunology, Calgranulin A metabolism, Calgranulin B genetics, Calgranulin B pharmacology, Cell Line, Tumor, Cell Movement drug effects, Female, Humans, Inflammation immunology, Macrophages immunology, Macrophages metabolism, Male, Middle Aged, Neoplasm Staging, Neutrophils immunology, Neutrophils metabolism, Prognosis, Protein Multimerization, Stomach Neoplasms genetics, Stomach Neoplasms mortality, Calgranulin B immunology, Stomach Neoplasms immunology, Stomach Neoplasms pathology
- Abstract
Background: S100A9 was originally discovered as a factor secreted by inflammatory cells. Recently, S100A9 was found to be associated with several human malignancies. The purpose of this study is to investigate S100A9 expression in gastric cancer and explore its role in cancer progression., Methods: S100A9 expression in gastric tissue samples from 177 gastric cancer patients was assessed by immunohistochemistry. The expression of its dimerization partner S100A8 and the S100A8/A9 heterodimer were also assessed by the same method. The effect of exogenous S100A9 on motility of gastric cancer cells AGS and BGC-823 was then investigated., Results: S100A9 was specifically expressed by inflammatory cells such as macrophages and neutrophils in human gastric cancer and gastritis tissues. Statistical analysis showed that a high S100A9 cell count (> = 200) per 200x magnification microscopic field in cancer tissues was predictive of early stage gastric cancer. High S100A9-positive cell count was negatively correlated with lymph node metastasis (P = 0.009) and tumor invasion (P = 0.011). S100A9 was identified as an independent prognostic predictor of overall survival of patients with gastric cancer (P = 0.04). Patients with high S100A9 cell count were with favorable prognosis (P = 0.021). Further investigation found that S100A8 distribution in human gastric cancer tissues was similar to S100A9. However, the number of S100A8-positive cells did not positively correlate with patient survival. The inflammatory cells infiltrating cancer were S100A8/A9 negative, while those in gastritis were positive. Furthermore, exogenous S100A9 protein inhibited migration and invasion of gastric cancer cells., Conclusions: Our results suggested S100A9-positive inflammatory cells in gastric cancer tissues are associated with early stage of gastric cancer and good prognosis.
- Published
- 2012
- Full Text
- View/download PDF
9. A cell-based screen for anticancer activity of 13 pyrazolone derivatives.
- Author
-
Wang XH, Wang XK, Liang YJ, Shi Z, Zhang JY, Chen LM, and Fu LW
- Subjects
- ATP Binding Cassette Transporter, Subfamily B, Member 1 metabolism, Animals, Antineoplastic Agents administration & dosage, Antineoplastic Agents chemistry, Antineoplastic Agents pharmacology, Antineoplastic Agents, Phytogenic pharmacology, Dose-Response Relationship, Drug, Drug Resistance, Neoplasm, Female, Hep G2 Cells, Humans, Inhibitory Concentration 50, KB Cells, Male, Mice, Mice, Inbred BALB C, Mice, Nude, Neoplasm Transplantation, Pyrazolones administration & dosage, Pyrazolones chemistry, Structure-Activity Relationship, Tumor Burden drug effects, Vincristine pharmacology, Cell Proliferation drug effects, Drug Resistance, Multiple, Ovarian Neoplasms pathology, Pyrazolones pharmacology
- Abstract
Background and Objective: Pyrazolone derivatives were reported to have a potent cytotoxicity against some tumor cells. In the present study, we evaluated the cytotoxic activity of a series of pyrazolone derivatives against four human tumor cell lines including HepG2, OVCAR3, KB, and multidrug resistance (MDR) KBv200 cell lines in vitro and in vivo. Additionally, the structure-activity relationships of these compounds were discussed., Methods: To analyze the antiproliferative potential of the synthesized compounds against several human tumor cell lines, the 50% inhibitory concentration (IC50) values were determined by MTT assay. Besides, the KBv200 cell xenograft experimental model was established and the sensitivity to the pyrazolone compounds was compared between drug-sensitive parental KB cells and MDR KBv200 cells., Results: Of 13 compounds screened, compound 9 presented remarkable anticancer effects, of which IC50 values were (3.24 ± 0.28), (2.58 ± 0.61), (3.81 ± 0.02), and (3.45 ± 0.03) μg/mL in HepG2, OVCAR3, KB and MDR KBv200 cells, respectively (P > 0.05). Furthermore, compound 9 effectively inhibited tumor growth of KBv200 cell xenografts in vivo, the inhibition ratio was 25.37%, 38.43%, and 47.50% for 1.5 mg/kg, 3 mg/kg, and 6 mg/kg of compound 9 groups, respectively., Conclusion: Compound 9 was the most promising antitumor agent in this study.
- Published
- 2010
- Full Text
- View/download PDF
10. Recurrence in oral and pharyngeal cancer is associated with quantitative MGMT promoter methylation.
- Author
-
Taioli E, Ragin C, Wang XH, Chen J, Langevin SM, Brown AR, Gollin SM, Garte S, and Sobol RW
- Subjects
- Aged, Cyclin-Dependent Kinase Inhibitor p16 genetics, Cyclin-Dependent Kinase Inhibitor p16 metabolism, DNA Modification Methylases metabolism, DNA Repair Enzymes metabolism, Female, Humans, Male, Middle Aged, Mouth Neoplasms metabolism, Mouth Neoplasms mortality, Mouth Neoplasms pathology, Pharyngeal Neoplasms metabolism, Pharyngeal Neoplasms mortality, Pharyngeal Neoplasms pathology, Recurrence, Survival, Tumor Suppressor Proteins metabolism, DNA Methylation, DNA Modification Methylases genetics, DNA Repair Enzymes genetics, Mouth Neoplasms genetics, Pharyngeal Neoplasms genetics, Promoter Regions, Genetic, Tumor Suppressor Proteins genetics
- Abstract
Background: Biomarkers that predict clinical response, tumor recurrence or patient survival are severely lacking for most cancers, particularly for oral and pharyngeal cancer. This study examines whether gene-promoter methylation of tumor DNA correlates with survival and recurrence rates in a population of patients with oral or pharyngeal cancer., Methods: The promoter methylation status of the DNA repair gene MGMT and the tumor suppressor genes CDKN2A and RASSF1 were evaluated by methylation-specific PCR in 88 primary oral and pharyngeal tumors and correlated with survival and tumor recurrence. Quantitative MGMT methylation was also assessed., Results: 29.6% of the tumors presented with MGMT methylation, 11.5% with CDKN2A methylation and 12.1% with RASSF1 methylation. MGMT promoter methylation was significantly associated with poorer overall and disease-free survival. No differences in methylation status of MGMT and RASSF1 with HPV infection, smoking or drinking habits were observed. A significant inverse trend with the amount of MGMT methylation and overall and disease-free survival was observed (ptrend = 0.002 and 0.001 respectively)., Conclusion: These results implicate MGMT promoter methylation as a possible biomarker for oral and pharyngeal cancer prognosis. The critical role of MGMT in DNA repair suggests that defective DNA repair may be correlative in the observed association between MGMT promoter methylation and tumor recurrence. Follow-up studies should include further quantitative MSP-PCR measurement, global methylation profiling and detailed analysis of downstream DNA repair genes regulated by promoter methylation.
- Published
- 2009
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.