1. Decreased expression of microRNA-124 is an independent unfavorable prognostic factor for patients with breast cancer
- Author
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Liang-liang Dong, Li-ming Chen, Wei-min Wang, and Liang-ming Zhang
- Subjects
Pathology ,medicine.medical_specialty ,Histology ,MicroRNA-124 ,Down-Regulation ,Breast Neoplasms ,Kaplan-Meier Estimate ,Real-Time Polymerase Chain Reaction ,Pathology and Forensic Medicine ,Breast cancer ,Predictive Value of Tests ,Risk Factors ,microRNA ,Carcinoma ,Biomarkers, Tumor ,Medicine ,Humans ,Clinical significance ,skin and connective tissue diseases ,Neoplasm Staging ,Proportional Hazards Models ,Chi-Square Distribution ,business.industry ,Proportional hazards model ,Reverse Transcriptase Polymerase Chain Reaction ,Research ,MicroRNA ,Cell Differentiation ,General Medicine ,Biomarker ,Middle Aged ,medicine.disease ,Prognosis ,MicroRNAs ,Real-time polymerase chain reaction ,Predictive value of tests ,Lymphatic Metastasis ,Multivariate Analysis ,Biomarker (medicine) ,Female ,business - Abstract
Background MicroRNA-124 (miR-124) has been reported to be downregulated in breast cancer. However, its clinical significance and prognostic value in breast cancer have not been extensively studied. Methods The tissue expression levels of miR-124 were measured using quantitative real-time PCR in 133 breast cancer patients. The correlation between the miR-124 levels and the clinicopathological factors of the patients was also analyzed. Survival and Cox proportional-hazards regression analyses were performed to determine the correlation between miR-124 expression levels and prognosis in the patients. Results Quantitative real-time PCR analysis showed that miR-124 had lower expression in breast cancer specimens than that in matched adjacent normal breast tissues (0.39 ± 0.16 vs. 1.00 ± 0.39; P
- Published
- 2015