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Your search keyword '"Won, Hong‐Hee"' showing total 12 results
Start Over Author "Won, Hong‐Hee" Publisher biomed central
12 results on '"Won, Hong‐Hee"'

5. Large multi-ethnic genetic analyses of amyloid imaging identify new genes for Alzheimer disease

Author

Ali, Muhammad, Archer, Derek B., Gorijala, Priyanka, Western, Daniel, Timsina, Jigyasha, Fernández, Maria V., Wang, Ting-Chen, Satizabal, Claudia L., Yang, Qiong, Beiser, Alexa S., Wang, Ruiqi, Chen, Gengsheng, Gordon, Brian, Benzinger, Tammie L. S., Xiong, Chengjie, Morris, John C., Bateman, Randall J., Karch, Celeste M., McDade, Eric, Goate, Alison, Seshadri, Sudha, Mayeux, Richard P., Sperling, Reisa A., Buckley, Rachel F., Johnson, Keith A., Won, Hong-Hee, Jung, Sang-Hyuk, Kim, Hang-Rai, Seo, Sang Won, Kim, Hee Jin, Mormino, Elizabeth, Laws, Simon M., Fan, Kang-Hsien, Kamboh, M. Ilyas, Vemuri, Prashanthi, Ramanan, Vijay K., Yang, Hyun-Sik, Wenzel, Allen, Rajula, Hema Sekhar Reddy, Mishra, Aniket, Dufouil, Carole, Debette, Stephanie, Lopez, Oscar L., DeKosky, Steven T., Tao, Feifei, Nagle, Michael W., Hohman, Timothy J., Sung, Yun Ju, Dumitrescu, Logan, and Cruchaga, Carlos

Published
2023
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8. Identifying novel genetic variants for brain amyloid deposition: a genome-wide association study in the Korean population

Author

Kim, Hang-Rai, Jung, Sang-Hyuk, Kim, Jaeho, Jang, Hyemin, Kang, Sung Hoon, Hwangbo, Song, Kim, Jun Pyo, Kim, So Yeon, Kim, Beomsu, Kim, Soyeon, Jeong, Jee Hyang, Yoon, Soo Jin, Park, Kyung Won, Kim, Eun-Joo, Yoon, Bora, Jang, Jae-Won, Hong, Jin Yong, Choi, Seong Hye, Noh, Young, Kim, Ko Woon, Kim, Si Eun, Lee, Jin San, Jung, Na-Yeon, Lee, Juyoun, Kim, Byeong C., Son, Sang Joon, Hong, Chang Hyung, Na, Duk L., Seo, Sang Won, Won, Hong-Hee, and Kim, Hee Jin

Published
2021
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12. Comparative analysis of the JAK/STAT signaling through erythropoietin receptor and thrombopoietin receptor using a systems approach.

Author

Won HH, Park I, Lee E, Kim JW, and Lee D

Subjects
Computer Simulation, Janus Kinases genetics, Kinetics, Mutation, Myeloproliferative Disorders metabolism, Receptors, Erythropoietin genetics, Receptors, Thrombopoietin genetics, STAT Transcription Factors genetics, Systems Biology, Janus Kinases metabolism, Receptors, Erythropoietin metabolism, Receptors, Thrombopoietin metabolism, STAT Transcription Factors metabolism, Signal Transduction
Abstract

Background: The Janus kinase-signal transducer and activator of transcription (JAK/STAT) pathway is one of the most important targets for myeloproliferative disorder (MPD). Although several efforts toward modeling the pathway using systems biology have been successful, the pathway was not fully investigated in regard to understanding pathological context and to model receptor kinetics and mutation effects., Results: We have performed modeling and simulation studies of the JAK/STAT pathway, including the kinetics of two associated receptors (the erythropoietin receptor and thrombopoietin receptor) with the wild type and a recently reported mutation (JAK2V617F) of the JAK2 protein., Conclusion: We found that the different kinetics of those two receptors might be important factors that affect the sensitivity of JAK/STAT signaling to the mutation effect. In addition, our simulation results support clinically observed pathological differences between the two subtypes of MPD with respect to the JAK2V617F mutation.

Published
2009
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