1. Clinical significance of mitofusin-2 and its signaling pathways in hepatocellular carcinoma
- Author
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Xiaobo Xu, Weilin Wang, Dongkai Zhou, Wei Song, Xinyi Zhao, Xiaohu Zhou, Pengfei Huang, Yingsheng Wu, Hua Guo, and Shusen Zheng
- Subjects
0301 basic medicine ,Male ,Cell signaling ,Carcinoma, Hepatocellular ,Hepatocellular carcinoma ,MFN2 ,Down-Regulation ,Apoptosis ,Kaplan-Meier Estimate ,Mitochondrion ,Real-Time Polymerase Chain Reaction ,GTP Phosphohydrolases ,Mitochondrial Proteins ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Biomarkers, Tumor ,Humans ,Overall survival ,RNA, Messenger ,Network function ,Aged ,Microarray analysis techniques ,business.industry ,Research ,Liver Neoplasms ,Hep G2 Cells ,Middle Aged ,medicine.disease ,Microarray Analysis ,digestive system diseases ,Mitochondria ,Up-Regulation ,030104 developmental biology ,Real-time polymerase chain reaction ,Oncology ,030220 oncology & carcinogenesis ,Cancer research ,Surgery ,Female ,Signal transduction ,business ,Signal Transduction - Abstract
Background The mitochondrial GTPase mitofusin-2 (MFN2) gene encodes a mitochondrial membrane protein that can induce apoptosis of hepatocellular carcinoma (HCC) via the mitochondrial apoptotic pathway, as validated in our previous research. However, little is known of the clinical significance of MFN2 expression and its signaling pathways in HCC. Methods MFN2 mRNA expression in tumor and adjacent non-tumor tissues from 115 patients with HCC was investigated using quantitative real-time PCR. The association of the MFN2 mRNA expression level with clinical and pathological parameters was evaluated statistically, while a comparative microarray analysis was used to identify MFN2 signaling pathways in HepG2 cells. Results MFN2 was significantly (p
- Published
- 2016