1. Prognostic impact of estimated remnant-like particle cholesterol in patients with differing glycometabolic status: an observational cohort study from China
- Author
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Ting-Yu Zhang, Yujing Cheng, Yujie Zhou, Ying-Kai Xu, Qi Zhao, Yue Ma, and Jiaqi Yang
- Subjects
0301 basic medicine ,Male ,medicine.medical_specialty ,Acute coronary syndrome ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,Lipoproteins ,Clinical Biochemistry ,Population ,Kaplan-Meier Estimate ,030204 cardiovascular system & hematology ,Percutaneous coronary intervention ,Prediabetic State ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Internal medicine ,medicine ,Remnant-like particle cholesterol ,Humans ,Myocardial infarction ,Acute Coronary Syndrome ,education ,Adverse effect ,Non-ST Elevated Myocardial Infarction ,lcsh:RC620-627 ,Triglycerides ,Aged ,Retrospective Studies ,education.field_of_study ,business.industry ,Research ,Biochemistry (medical) ,Hazard ratio ,Non-ST-segment elevation acute coronary syndrome ,Middle Aged ,medicine.disease ,Prognosis ,lcsh:Nutritional diseases. Deficiency diseases ,030104 developmental biology ,Cholesterol ,Area Under Curve ,Conventional PCI ,Female ,business ,Cohort study - Abstract
Background It is uncertain whether estimated remnant-like particle cholesterol (RLP-C) could predict residual risk in patients with different glycometabolic status. This study aimed to evaluate the relationship between estimated RLP-C and adverse prognosis in patients with non-ST-segment elevation acute coronary syndrome (NSTE-ACS) treated with percutaneous coronary intervention (PCI) and to identify the potential impact of glycometabolism on the predictive value of estimated RLP-C. Methods The study assessed 2419 participants with NSTE-ACS undergoing PCI at Beijing Anzhen Hospital from January to December 2015. Estimated RLP-C was calculated as follows: total cholesterol (TC) minus low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C). The adverse events included all-cause death, non-fatal myocardial infarction (MI), and ischemia-driven revascularization. Results Estimated RLP-C was prominently associated with adverse prognosis in the total population [hazard ratio (HR) 1.291 per 1-SD increase, 95% confidence interval (CI) 1.119–1.490, P P Conclusions High estimated RLP-C level is a significant predictor for recurrent adverse events in patients with diabetes and NSTE-ACS treated with PCI.
- Published
- 2020