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Your search keyword '"Yousefi, Mehdi"' showing total 17 results
Start Over Author "Yousefi, Mehdi" Publisher biomed central
17 results on '"Yousefi, Mehdi"'

11. A comprehensive evaluation of the immune system response and type-I Interferon signaling pathway in hospitalized COVID-19 patients

Author

Soltani-Zangbar, Mohammad Sadegh, Parhizkar, Forough, Ghaedi, Elham, Tarbiat, Ali, Motavalli, Roza, Alizadegan, Amin, Aghebati-Maleki, Leili, Rostamzadeh, Davoud, Yousefzadeh, Yousef, Jadideslam, Golamreza, Farid, Sima Shahmohammadi, Roshangar, Leila, Mahmoodpoor, Ata, Heris, Javad Ahmadian, Miahipour, Abolfazl, and Yousefi, Mehdi

Published
2022
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17. Phage display as a promising approach for vaccine development.

Author

Aghebati-Maleki, Leili, Bakhshinejad, Babak, Baradaran, Behzad, Motallebnezhad, Morteza, Aghebati-Maleki, Ali, Nickho, Hamid, Yousefi, Mehdi, and Majidi, Jafar

Subjects
BACTERIOPHAGES, VACCINES, IMMUNOLOGICAL adjuvants, ANTIGENS, LIGANDS (Biochemistry), INFECTION
Abstract

Bacteriophages are specific antagonists to bacterial hosts. These viral entities have attracted growing interest as optimal vaccine delivery vehicles. Phages are well-matched for vaccine design due to being highly stable under harsh environmental conditions, simple and inexpensive large scale production, and potent adjuvant capacities. Phage vaccines have efficient immunostimulatory effects and present a high safety profile because these viruses have made a constant relationship with the mammalian body during a long-standing evolutionary period. The birth of phage display technology has been a turning point in the development of phage-based vaccines. Phage display vaccines are made by expressing multiple copies of an antigen on the surface of immunogenic phage particles, thereby eliciting a powerful and effective immune response. Also, the ability to produce combinatorial peptide libraries with a highly diverse pool of randomized ligands has transformed phage display into a straightforward, versatile and high throughput screening methodology for the identification of potential vaccine candidates against different diseases in particular microbial infections. These libraries can be conveniently screened through an affinity selection-based strategy called biopanning against a wide variety of targets for the selection of mimotopes with high antigenicity and immunogenicity. Also, they can be panned against the antiserum of convalescent individuals to recognize novel peptidomimetics of pathogen-related epitopes. Phage display has represented enormous promise for finding new strategies of vaccine discovery and production and current breakthroughs promise a brilliant future for the development of different phage-based vaccine platforms. [ABSTRACT FROM AUTHOR]

Published
2016
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