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Your search keyword '"Zhang, RuiFeng"' showing total 10 results
Start Over Author "Zhang, RuiFeng" Publisher biomed central
10 results on '"Zhang, RuiFeng"'

3. Correction to: Prediction and prognosis of adverse maternal and foetal/neonatal outcomes in pulmonary hypertension: an observational study and nomogram construction

Author

Chen, Yuqin, Zhou, Dansha, Xiong, Mingmei, Xi, Xin, Zhang, Wenni, Zhang, Ruifeng, Chen, Lishi, Jiang, Qian, Lai, Ning, Li, Xiang, Luo, Jieer, Li, Xuanyi, Feng, Weici, Gao, Chuhui, Chen, Jiyuan, Fu, Xin, Hong, Wei, Jiang, Mei, Yang, Kai, Lu, Wenju, Luo, Yiping, Zhang, Jun, Cheng, Zhe, Liu, Chunli, and Wang, Jian

Published
2023
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5. Prediction and prognosis of adverse maternal and foetal/neonatal outcomes in pulmonary hypertension: an observational study and nomogram construction

Author

Chen, Yuqin, Zhou, Dansha, Xiong, Mingmei, Xi, Xin, Zhang, Wenni, Zhang, Ruifeng, Chen, Lishi, Jiang, Qian, Lai, Ning, Li, Xiang, Luo, Jieer, Li, Xuanyi, Feng, Weici, Gao, Chuhui, Chen, Jiyuan, Fu, Xin, Hong, Wei, Jiang, Mei, Yang, Kai, Lu, Wenju, Luo, Yiping, Zhang, Jun, Cheng, Zhe, Liu, Chunli, and Wang, Jian

Published
2022
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6. Phenotypic spectrum and genetics of PAX2-related disorder in the Chinese cohort

Author

Yang, Xue, Li, Yaqi, Fang, Ye, Shi, Hua, Xiang, Tianchao, Liu, Jiaojiao, Liu, Jialu, Tang, Xiaoshan, Fang, Xiaoyan, Chen, Jing, Zhai, Yihui, Shen, Qian, Bi, Yunli, Qian, Yanyan, Wu, Bingbing, Wang, Huijun, Zhou, Wenhao, Ma, Duan, Bai, Haitao, Mao, Jianhua, Chen, Lizhi, Wang, Xiaowen, Gao, Xiaojie, Zhang, Ruifeng, Zhuang, Jieqiu, Zhang, Aihua, Jiang, Xiaoyun, Xu, Hong, and Rao, Jia

Published
2021
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10. LncRNA H19 promotes the proliferation of pulmonary artery smooth muscle cells through AT1R via sponging let-7b in monocrotaline-induced pulmonary arterial hypertension.

Author

Su, Hua, Xu, Xiaoling, Yan, Chao, Shi, Yangfeng, Hu, Yanjie, Dong, Liangliang, Ying, Songmin, Ying, Kejing, and Zhang, Ruifeng

Subjects
PULMONARY hypertension, SMOOTH muscle, MUSCLE cells, LINCRNA, MICRORNA, LABORATORY rats
Abstract

Background: Pulmonary arterial hypertension (PAH) is related to inflammation, and the lncRNA H19 is associated with inflammation. However, whether PDGF-BB-H19-let-7b-AT1R axis contributes to the pathogenesis of PAH has not been thoroughly elucidated to date. This study investigated the role of H19 in PAH and its related mechanism.Methods: In the present study, SD rats, C57/BL6 mice and H19-/- mice were injected with monocrotaline (MCT) to establish a PAH model. H19 was detected in the cytokine-stimulated pulmonary arterial smooth muscle cells (PASMCs), serum and lungs of rats/mice. H19 overexpression and knockdown experiments were also conducted. A dual luciferase reporter assay was used to explore whether let-7b is a sponge miRNA of H19, and AT1R is a novel target of let-7b. A CCK-8 assay and flow cytometry were used to analyse cell proliferation.Results: The results showed that H19 was highly expressed in the serum and lungs of MCT-induced rats/mice, and H19 was upregulated by PDGF-BB in vitro. H19 upregulated AT1R expression via sponging miRNA let-7b following PDGF-BB stimulation. AT1R is a novel target of let-7b. Moreover, the overexpression of H19 and AT1R could facilitate PASMCs proliferation in vitro. H19 knockout protected mice from pulmonary artery remodeling and PAH following MCT treatment.Conclusion: Our study showed that H19 is highly expressed in MCT-induced rodent lungs and upregulated by PDGF-BB. The H19-let-7b-AT1R axis contributed to the pathogenesis of PAH by stimulating PASMCs proliferation. The H19 knockout had a protective role in the development of PAH. H19 may be a potential tar-get for the treatment of PAH. [ABSTRACT FROM AUTHOR]

Published
2018
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