3 results on '"alzamora, Maite"'
Search Results
2. The population-based Barcelona-Asymptomatic Intracranial Atherosclerosis Study (ASIA): rationale and design
- Author
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López-Cancio, Elena, Dorado Bouix, Laura, Millán, Mónica, Reverté, Silvia, Suñol, Anna, Massuet, Anna, Mataró, María, Galán, Amparo, Alzamora, Maite, Pera, Guillem, Torán, Pere, Dávalos, Antoni, Arenillas, Juan F., and Universitat Autònoma de Barcelona
- Subjects
medicine.medical_specialty ,Population ,Clinical Neurology ,Disease ,Asymptomatic ,lcsh:RC346-429 ,Magnetic resonance angiography ,White People ,Study Protocol ,Random Allocation ,Internal medicine ,medicine ,Prevalence ,Humans ,Ultrasonography, Doppler, Color ,education ,Stroke ,lcsh:Neurology. Diseases of the nervous system ,education.field_of_study ,medicine.diagnostic_test ,business.industry ,General Medicine ,medicine.disease ,Intracranial Arteriosclerosis ,Prognosis ,Surgery ,Natural history ,Early Diagnosis ,Spain ,Epidemiologic Research Design ,Population Surveillance ,Cohort ,Disease Progression ,Neurology (clinical) ,Neurosurgery ,medicine.symptom ,business ,Magnetic Resonance Angiography - Abstract
Background Large-artery intracranial atherosclerosis may be the most frequent cause of ischemic stroke worldwide. Traditional approaches have attempted to target the disease when it is already symptomatic. However, early detection of intracranial atherosclerosis may allow therapeutic intervention while the disease is still asymptomatic. The prevalence and natural history of asymptomatic intracranial atherosclerosis in Caucasians remain unclear. The aims of the Barcelona-ASymptomatic Intracranial Atherosclerosis (ASIA) study are (1) to determine the prevalence of ASIA in a moderate-high vascular risk population, (2) to study its prognostic impact on the risk of suffering future major ischemic events, and (3) to identify predictors of the development, progression and clinical expression of this condition. Methods/Design Cross-over and cohort, population-based study. A randomly selected representative sample of 1,503 subjects with a mild-moderate-high vascular risk (as defined by a REGICOR score ≥ 5%) and with neither a history of cerebrovascular nor ischemic heart disease will be studied. At baseline, all individuals will undergo extracranial and transcranial Color-Coded Duplex (TCCD) ultrasound examinations to detect presence and severity of extra and intracranial atherosclerosis. Intracranial stenoses will be assessed by magnetic resonance angiography (MRA). Clinical and demographic variables will be recorded and blood samples will be drawn to investigate clinical, biological and genetic factors associated with the presence of ASIA. A long-term clinical and sonographic follow-up will be conducted thereafter to identify predictors of disease progression and of incident vascular events. Discussion The Barcelona-ASIA is a population-based study aiming to evaluate the prevalence and clinical importance of asymptomatic intracranial large-artery atherosclerosis in Caucasians. The ASIA project may provide a unique scientific resource to better understand the dynamics of intracranial atherosclerosis from its early stages and to identify new potential therapeutic targets for this condition.
- Published
- 2011
3. "Burden of osteoporotic fractures in primary health care in Catalonia (Spain): a population-based study"
- Author
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Pagès-Castellè, Aina, Carbonell-Abella, Cristina, Fina Avilés, Francesc, Alzamora, Maite, Baena-Díez, Jose Miguel, Martínez Laguna, Daniel, Nogués, Xavier, Díez-Pérez, Adolfo, and Prieto-Alhambra, Daniel
- Subjects
BONE fractures ,BONE injuries ,MEDICAL care ,PRIMARY health care - Abstract
Background: Knowledge on the epidemiology of non-hip fractures in Spain is limited and somewhat outdated. Using computerized primary care records from the SIDIAP database, we derived age and sex-specific fracture incidence rates for the region of Catalonia during the year 2009. Methods: The SIDIAP database contains quality-checked clinical information from computerized medical records of a representative sample of >5,800,000 patients (80% of the population of Catalonia). We conducted a retrospective cohort study including all patients aged ≥50 years, and followed them from January 1 to December 31, 2009. Major osteoporotic fractures registered in SIDIAP were ascertained using ICD-10 codes and validated by comparing data to hospital admission and patient-reported fractures records. Incidence rates and 95% confidence intervals were calculated. Results: In total, 2,011,430 subjects were studied (54.6% women). Overall fracture rates were 10.91/1,000 person-years (py) [95%CI 10.89-10.92]: 15.18/1,000 py [15.15-15.21] in women and 5.78/1,000 py [5.76-5.79] in men. The most common fracture among women was wrist/forearm (3.86/1,000 py [3.74-3.98]), while among men it was clinical spine (1.25/1,000 py [1.18-1.33]). All fracture rates increased with age, but varying patterns were observed: while most of the fractures (hip, proximal humerus, clinical spine and pelvis) increased continuously with age, wrist and multiple rib fractures peaked at age 75-80 and then reached a plateau. Conclusions: Our study provides local estimates of age, sex and site-specific fracture burden in primary health care, which will be helpful for health-care planning and delivery. A proportion of fractures are not reported in primary care records, leading to underestimation of fracture incidence rates in these data. [ABSTRACT FROM AUTHOR]
- Published
- 2012
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