1. Fatty acids composition and in vivo biochemical effects of Aleurites moluccana seed (Candlenut) in obese wistar rats.
- Author
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de Britto Rosa MC, Ribeiro PR, de Oliveira Silva V, Selvati-Rezende DAC, da Silva TP, Souza FR, Cardoso MDG, Seixas JN, Andrade EF, Pardi V, Murata RM, and Pereira LJ
- Abstract
Background: Candlenut (CN) has been used indiscriminately for weight loss. In vivo effects of CN in different doses are scarce., Objective: To evaluate the effects of CN ingestion in obese rats., Design: Thirty animals (obese and non-obese) received one of three different types of treatments: placebo, CN ingestion in a popular therapeutic regimen (8 days with oral administration of 0.2 mg/kg followed by 20 days with doses of 0.4 mg/kg), and ingestion of a doubled popular dose-called 2CN. Treatment was maintained for 28 days., Results: The fatty acid profile of CN indicated mainly linolelaidic and palmitoleic acids. Rats receiving CN and 2CN showed reduced plasmatic levels of glucose and lipoproteins (p < 0.05). A dose-dependent carcass fat reduction was observed (p < 0.05). Blood levels of aspartate aminotransferase (AST) and gamma-glutamyl transferase (GGT) reduced with CN and increased with 2CN doses (p < 0.05). Alanine aminotransferase (ALT) and the atherogenic index remained similar among all treatments (p > 0.05). Hepatic vacuolation decreased with CN, but the 2CN dose produced mononuclear leucocyte infiltrate., Conclusions: Although CN presented beneficial effects on the metabolism of rats, it also caused increased risk of liver damage., (© 2022. The Author(s).)
- Published
- 2022
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