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Your search keyword '"G. Attaguile"' showing total 2 results
Start Over Author "G. Attaguile" Publisher bioscience ediprint
2 results on '"G. Attaguile"'

1. Pharmacological properties and toxicology of MED-15, a prodrug of tolmetin.

Author

Caruso A, Cutuli VM, De Bernardis E, Attaguile G, and Amico-Roxas M

Subjects
Administration, Oral, Animals, Anti-Inflammatory Agents, Non-Steroidal toxicity, Female, Glycine pharmacology, Glycine toxicity, Lethal Dose 50, Male, Peptic Ulcer chemically induced, Prodrugs toxicity, Pyrroles toxicity, Rats, Rats, Wistar, Tolmetin toxicity, Anti-Inflammatory Agents, Non-Steroidal pharmacology, Glycine analogs & derivatives, Prodrugs pharmacology, Pyrroles pharmacology, Tolmetin pharmacology
Abstract

In this study the pharmacological evaluation of MED-15, a non-acidic prodrug of tolmetin, is described. After oral administration the new compound shows a marked anti-inflammatory activity similar to that of tolmetin, but with minor ulcerogenic action and lower acute toxicity.

Published
1992

2. Influence of sodium valproate and carbamazepine on GSH levels in rat cerebral cortex.

Author

Attaguile G, Caruso A, Cutuli VM, Di Giacomo C, Russo A, De Bernardis E, and Amico-Roxas M

Subjects
Administration, Oral, Animals, Drug Interactions, Male, Rats, Rats, Wistar, Carbamazepine pharmacology, Cerebral Cortex drug effects, Cerebral Cortex metabolism, Glutathione metabolism, Valproic Acid pharmacology
Abstract

The effects of sodium valproate (150 mg/kg) and carbamazepine (300 mg/kg), alone and in combination, on the content of glutathione (GSH) were investigated in the rat cerebral cortex. No modification was found either 4, 12 or 16 hours after treatment, suggesting that sodium valproate and carbamazepine do not affect the cortical GSH metabolism in rats.

Published
1992

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